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NCT05273996 · ClinicalTrials.gov registry record · Phase 4
Predictors of Cognitive Outcomes in Geriatric Depression
A Phase 4 study of Major Depressive Disorder and Stress, sponsored by David Steffens.
- Active
- Registry status
- Phase 4
- Development phase
- 75
- Enrollment target
- 1
- Study location
NCT05273996: Active Phase 4 study of Major Depressive Disorder and Stress, sponsored by David Steffens.
NCT05273996 is a Phase 4 study of Major Depressive Disorder and Stress that is active but no longer recruiting, run by David Steffens. The registered enrollment target is 75 participants, below the 377-participant average among 282 other Major Depressive Disorder trials with a reported enrollment target (80% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05273996, a Phase 4 study of Major Depressive Disorder and Stress, is active but no longer recruiting, sponsored by David Steffens.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 4
- Development phase
- 75 participants
- Enrollment target
- 1
- Study location
Study Summary
This study will focus on examining effects of stress on long-term mood and cognitive outcomes of late-life depression. It will also example the neural underpinnings of these changes using structural and functional brain imaging. Understanding how effects of stress in older depressed adults, as well as factors that might minimize those effects, lead to particular mood and cognitive outcomes will inform future development of novel prevention strategies.
Primary Outcome
Measure of depression severity and Recurrence of Depression Minimum Score = 0; Maximum Score = 60; Higher score means worse outcome
Conditions Studied
Interventions
- DRUG Sertraline, bupropion, desvenlafaxine
Study Locations (1)
Connecticut
- UConn Health - Farmington
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 75 participants |
| Start Date | 2021-09-28 |
| Est. Completion | 2026-06-30 |
| Phase | Phase 4 |
What the registry record for NCT05273996 still lists
NCT05273996 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 75 participants, a relatively small participant target, below the 377-participant average among 282 other Major Depressive Disorder trials with a reported enrollment target (80% lower).
The record links to 4 conditions, with Major Depressive Disorder appearing as the primary indexed condition, and to 1 intervention - of which Sertraline, bupropion, desvenlafaxine is the first listed.
NCT05273996 reports a single indexed study location in Connecticut.
Frequently Asked Questions
What is clinical trial NCT05273996 about?
NCT05273996 is a clinical study titled "Predictors of Cognitive Outcomes in Geriatric Depression". This study will focus on examining effects of stress on long-term mood and cognitive outcomes of late-life depression. It will also example the neural underpinnings of these changes using structural and functional brain imaging. Understanding how effects of stress in older depressed adults, as well ...
What is the current status of trial NCT05273996?
This trial is currently active not recruiting. It is a Phase 4 study. The enrollment target is 75 participants. The study started on 2021-09-28. Estimated completion is 2026-06-30.
What conditions does trial NCT05273996 study?
This clinical trial studies the following conditions: Major Depressive Disorder, Stress, Cognitive Change, Neuroticism.
What interventions are being tested in trial NCT05273996?
The interventions under investigation include: Sertraline, bupropion, desvenlafaxine (DRUG).
Who is sponsoring clinical trial NCT05273996?
This trial is sponsored by David Steffens, which has 1 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05273996 being conducted?
This trial has 1 study location across Connecticut. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Major Depressive Disorder
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05273996's enrollment target sits among peer trials
75 150th of 282 higher than 131 of 282 other Major Depressive Disorder trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Major Depressive Disorder trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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