Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT06778421 · ClinicalTrials.gov registry record · Phase 1
Impact of OnabotulinumtoxinA (BOTOX®) on Stress
A Phase 1 study of Stress and Stress, Physiological, sponsored by Center for Advanced Facial Plastic Surgery.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 20
- Enrollment target
- 1
- Study location
NCT06778421: Recruiting Phase 1 study of Stress and Stress, Physiological, sponsored by Center for Advanced Facial Plastic Surgery.
NCT06778421 is a Phase 1 study of Stress and Stress, Physiological that is actively recruiting participants, run by Center for Advanced Facial Plastic Surgery. The registered enrollment target is 20 participants, below the 786-participant average among 152 other Stress trials with a reported enrollment target (97% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06778421, a Phase 1 study of Stress and Stress, Physiological, is actively recruiting participants, sponsored by Center for Advanced Facial Plastic Surgery.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 20 participants
- Enrollment target
- 1
- Study location
Study Summary
The purpose of this prospective single-center, blinded\*, randomized, proof-of-concept study is to determine whether OnabotulinumtoxinA (BOTOX®) injections will change the level of stress perceived by generally healthy adult female participants. It is hypothesized that BOTOX® injections will be associated with decreases in perceived stress levels, measured by scores on the Perceived Stress Scale (PSS) questionnaire. The primary outcome measure is a chronological decrease in PSS scores between any two points of the study period. Comparison of the placebo- and BOTOX®-treated participant scores will either support or disprove the study hypothesis. Qualified participants who meet the study requirements, including a one-time completion of basic laboratory testing before treatment. The treatment visit starts on day-1 of a 12-week period, which consists a total of four clinic visits and one online visit, which involve: * vital signs and Body Mass Index (BMI) measurements * basic/interval history and physical * 2 Perceived Stress Scale (PSS) questionnaires * injection of 64 units of either BOTOX® or sterile salt solution * stay for 60-minutes after treatment for monitoring and to complete study tasks
Primary Outcome
Chronological decrease at any two points between the first and last completed questionnaire
Conditions Studied
Interventions
- PROCEDURE Intramuscular injection
- DRUG OnabotulinumtoxinA (Botox®) Injections
- OTHER Sodium Chloride
Study Locations (1)
California
- Center for Advanced Facial Plastic Surgery - Beverly Hills
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 20 participants |
| Start Date | 2025-01-20 |
| Est. Completion | 2025-09 |
| Phase | Phase 1 |
What NCT06778421 shows while recruiting
NCT06778421 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 20 participants, a relatively small participant target, below the 786-participant average among 152 other Stress trials with a reported enrollment target (97% lower).
The record links to 9 conditions, with Stress appearing as the primary indexed condition, and to 3 interventions - of which Intramuscular injection is the first listed.
NCT06778421 reports a single indexed study location in California.
Frequently Asked Questions
What is clinical trial NCT06778421 about?
NCT06778421 is a clinical study titled "Impact of OnabotulinumtoxinA (BOTOX®) on Stress". The purpose of this prospective single-center, blinded\*, randomized, proof-of-concept study is to determine whether OnabotulinumtoxinA (BOTOX®) injections will change the level of stress perceived by generally healthy adult female participants. It is hypothesized that BOTOX® injections will be asso...
What is the current status of trial NCT06778421?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 20 participants. The study started on 2025-01-20. Estimated completion is 2025-09.
What conditions does trial NCT06778421 study?
This clinical trial studies the following conditions: Stress, Stress, Physiological, Stress Response, Stress (Psychology), Healthy Adult Female Participants.
What interventions are being tested in trial NCT06778421?
The interventions under investigation include: Intramuscular injection (PROCEDURE), OnabotulinumtoxinA (Botox®) Injections (DRUG), Sodium Chloride (OTHER).
Who is sponsoring clinical trial NCT06778421?
This trial is sponsored by Center for Advanced Facial Plastic Surgery, which has 1 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06778421 being conducted?
This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Stress
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06778421's enrollment target sits among peer trials
20 142nd of 152 higher than 8 of 152 other Stress trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Stress trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
Effects of Cannabidiol on Stress and Nicotine Withdrawal
RECRUITING · Phase 1
-
Study of Cannabidiol and Neuroimaging on Stress
RECRUITING · Phase 1
-
Stress Biomarkers:Attaching Biological Meaning to Field Friendly Salivary Measures
COMPLETED · Phase 1
-
The Effects of Smell on Mood and Physical Responses
COMPLETED · Phase 1
-
Decreasing Stress and Improving Self-control With "Stress in Control" (Sync) Training
COMPLETED · Phase 1
-
Surviving Daily Life
RECRUITING
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT00573339 · 20 participants
Cardiac Magnetic Resonance Imaging (MRI) Normal Reference Control Group Testing
- NCT00692939 · 20 participants · Phase 1
Autologous Stem Cell Transplantation for Crohn's Disease
- NCT00967785 · 20 participants · Phase 1
A Phase I Study of Mozobil in the Treatment of Patients With WHIMS
- NCT01406691 · 20 participants · Phase 4
Light Flashes to Treat Delayed Sleep Phase Disorder (DSPD)
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI