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2026 data Public-data reference. official source

Squamous Cell Carcinoma

Open-data reference.

48 US clinical trials · 17 currently recruiting

Active & Recent Trials

RECRUITING Phase 2 480 participants

Patient Preference for Subcutaneous vs. Intravenous Immune Therapy

Diwakar Davar

NCT07223424

RECRUITING Phase 2 225 participants

Use of SPY Imaging System to Minimize Fistulas After Hypopharyngeal Reconstruction

Matthew Spector

NCT06831149

RECRUITING Phase 2 120 participants

Radiotherapy With Cisplatin vs. Docetaxel-cetuximab in HNSCC: ERCC1 Biomarker Enrichment and Interaction Design

Christopher Wilke

NCT02128906

RECRUITING Phase 1 100 participants

Treating Basal and Squamous Cell Carcinomas With Fractional Laser and Tirbanibulin Ointment

Bruce Robinson, MD

NCT07010692

RECRUITING NA 94 participants

Sentinel Lymph Node Biopsy for Cutaneous Squamous Cell Carcinoma of the Head and Neck

Indiana University

NCT05108090

RECRUITING Phase 2 85 participants

T Cell Receptor Immunotherapy for Patients With Metastatic Non-Small Cell Lung Cancer

National Cancer Institute (NCI)

NCT02133196

RECRUITING NA 80 participants

Defining TRPV4 Contribution of Schwann Cells to Oral Cancer Pain

New York University

NCT07095608

RECRUITING Phase 2 75 participants

Neoadjuvant Chemotherapy and Programmed Cell Death Protein 1(PD-1) Inhibition for Head and Neck Cancer Treatment De-escalation (NeoScorch HN)

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT07209189

RECRUITING Phase 2 55 participants

Preoperative Immunotherapy in Patients With Squamous Cell Carcinoma of the Head and Neck

Alain Algazi

NCT03708224

RECRUITING Phase 2 35 participants

Immunotherapy With Chemotherapy and Chemoradiation for Advanced Squamous Cancer of Nasal Cavity / Paranasal Sinuses (I-NAPA)

M.D. Anderson Cancer Center

NCT05027633

RECRUITING Phase 1 30 participants

A Clinical Study of Intratumoral MVR-T3011 (T3011) Given as a Single Agent and in Combination With Intravenous Pembrolizumab in Participants With Advanced or Metastatic Solid Tumors

ImmVira Pharma Co.

NCT04370587

RECRUITING Phase 1 30 participants

Intratumoral Lidocaine Injection Before Oropharyngeal Cancer Surgery

Ryan Carey

NCT06747390

RECRUITING Phase 2 29 participants

Phase 2 Trial of Neoadjuvant and Adjuvant Tiragolumab Plus Atezolizumab in Patients With Newly Diagnosed PD-L1 CPS Positive Resectable Stage 3-4 Oral Cavity Squamous Cell Carcinoma (OCSCC).

M.D. Anderson Cancer Center

NCT05681039

RECRUITING Phase 2 25 participants

Study of Afatinib in Advanced Cutaneous Squamous Cell Carcinoma

H. Lee Moffitt Cancer Center and Research Institute

NCT05070403

RECRUITING Phase 2 20 participants

Toripalimab With Chemotherapy for Sinus Cancer

Glenn J. Hanna

NCT06940180

RECRUITING 20 participants

Raman Spectroscopy and Skin Cancer

Renee Farrell

NCT06384924

RECRUITING Phase 2 16 participants

Impact of COL7A1 Gene Therapy on SCC Recurrence in RDEB Skin

Stanford University

NCT06731933

ACTIVE NOT RECRUITING Phase 2 384 participants

De-intensified Radiation Therapy With Chemotherapy (Cisplatin) or Immunotherapy (Nivolumab) in Treating Patients With Early-Stage, HPV-Positive, Non-Smoking Associated Oropharyngeal Cancer

National Cancer Institute (NCI)

NCT03952585

ACTIVE NOT RECRUITING NA 150 participants

TORS De-Intensification Protocol Version 2.0: Dose and Volume Reduction in the Neck

Abramson Cancer Center at Penn Medicine

NCT03729518

ACTIVE NOT RECRUITING 72 participants

Analyzing Clinical Outcomes and Genomic Data of American Indian Patient Population

University of Oklahoma

NCT05863052

ACTIVE NOT RECRUITING Phase 2 48 participants

Quercetin Chemoprevention for Squamous Cell Carcinoma in Patients With Fanconi Anemia

Children's Hospital Medical Center, Cincinnati

NCT03476330

ACTIVE NOT RECRUITING Phase 2 45 participants

Nivolumab and BMS986205 in Treating Patients With Stage II-IV Squamous Cell Cancer of the Head and Neck

Thomas Jefferson University

NCT03854032

ACTIVE NOT RECRUITING NA 40 participants

Comparing Two Surveillance Approaches for People Who Have Received Treatment for HPV-associated Head and Neck Cancer and Show No Signs of Disease

Memorial Sloan Kettering Cancer Center

NCT05048459

ACTIVE NOT RECRUITING Phase 2 34 participants

A Study of Radiation Therapy and Cemiplimab for People With Skin Cancer

Memorial Sloan Kettering Cancer Center

NCT05574101

ACTIVE NOT RECRUITING Phase 2 30 participants

Neoadjuvant Study of PD-1 Inhibitor Pembrolizumab in PD-1 Naive Cutaneous Squamous Cell Carcinoma (cSCC)

Diwakar Davar

NCT04808999

ACTIVE NOT RECRUITING Phase 2 25 participants

Phase 2 Trial of Adaptive Radiotherapy Boost for HNSCC

H. Lee Moffitt Cancer Center and Research Institute

NCT06137274

ACTIVE NOT RECRUITING Phase 1 12 participants

Neo-adjuvant Treatment for Squamous Cell Carcinoma Using Direct Tumor Injection With RP1.

Sherrif Ibrahim

NCT05858229

ACTIVE NOT RECRUITING Phase 2 7 participants

1922GCCC: Pembro and Bavituximab for Squamous Cell Carcinoma of Head and Neck

University of Maryland, Baltimore

NCT04150900

COMPLETED 1,111 participants

DERM US and EU Validation Study

Skin Analytics Limited

NCT05126173

COMPLETED 279 participants

Observational Study of Swallowing Function After Treatment of Advanced Laryngeal Cancer

University of Minnesota

NCT01089803

COMPLETED 187 participants

Electronic Brachytherapy for the Treatment of NMSC

Xoft

NCT01016899

COMPLETED 180 participants

Does Cryofixation of Skin Specimens Affect Quality of Subsequent Formalin Fixed Paraffin Embedded H and E Histology

Abramson Cancer Center at Penn Medicine

NCT01540695

COMPLETED Phase 1 151 participants

A Study of DKN-01 in Combination With Paclitaxel or Pembrolizumab

Leap Therapeutics

NCT02013154

COMPLETED Phase 1 150 participants

A Phase 1 Study in Participants With Advanced Cancer

Eli Lilly and Company

NCT01115790

COMPLETED NA 75 participants

Safety and Efficacy of Oral Midazolam for Perioperative Anxiety Relief of Patients Undergoing Mohs Micrographic Surgery

Mayo Clinic

NCT00578214

COMPLETED Phase 1 59 participants

Pembrolizumab in Combination With CRT for LA-SCCHN

Sanford Health

NCT02586207

COMPLETED Phase 1 54 participants

Vaccine Treatment for Advanced Non-Small Cell Lung Cancer

NewLink Genetics Corporation

NCT00073398

COMPLETED 45 participants

Reflectance Confocal Microscopy of Wounds During Moh's Surgery: Feasibility Testing of a Mosaicing Algorithm for Intraoperative Imaging of Cancer Margins

Memorial Sloan Kettering Cancer Center

NCT01872130

COMPLETED Phase 2 40 participants

Photochemical Tissue Bonding

Massachusetts General Hospital

NCT00586040

COMPLETED Phase 1 35 participants

A Pilot Study of Paclitaxel With Radiation Therapy for Locally Advanced Head and Neck Cancer

National Cancer Institute (NCI)

NCT00001442

COMPLETED Phase 2 35 participants

De-Escalation Therapy for Human Papillomavirus Negative Disease

University of Chicago

NCT03944915

COMPLETED Phase 2 30 participants

Combination Chemotherapy for Locally Advanced Squamous Cell Carcinoma of the Head and Neck

Dana-Farber Cancer Institute

NCT00139230

COMPLETED NA 29 participants

Videoscopic Versus Open Inguinal Lymphadenectomy for Cancer

Emory University

NCT01526486

COMPLETED 24 participants

PET-MRI Assessment of Early Tumor Response to Predict Outcomes of HPV-Positive Oropharynx Cancer Patients

University of Wisconsin, Madison

NCT03342378

COMPLETED 20 participants

Study Evaluating Temsirolimus in Advanced Stage Squamous Cell Carcinoma of the Head & Neck

Wyeth is now a wholly owned subsidiary of Pfizer

NCT00195299

COMPLETED Phase 1 12 participants

IRX-2 Regimen Combined With Nivolumab in Recurrent/Metastatic Solid Tumors

H. Lee Moffitt Cancer Center and Research Institute

NCT03758781

COMPLETED Phase 1 6 participants

Radiation and Cetuximab Plus Intratumoral EGFR Antisense DNA in Locally Advanced Head and Neck Squamous Cell Carcinoma

The University of Texas Health Science Center at San Antonio

NCT01592721

COMPLETED NA 5 participants

Fluorine F 18 EF5 Positron Emission Tomography in Assessing Hypoxia in Patients With Newly Diagnosed Stage I, Stage II, Stage III, or Stage IV Head or Neck Squamous Cell Cancer of the Oral Cavity, Oropharynx, and Larynx

Abramson Cancer Center at Penn Medicine

NCT01020097

Phase Distribution

PhaseTrial count
Early Phase 1 11
Phase 2 21

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Squamous Cell Carcinoma Trial Landscape

ClinicalTrials.gov lists 48 US studies indexed under Squamous Cell Carcinoma, and 17 of those are currently open to recruitment — roughly 35% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Squamous Cell Carcinoma shows 0 late-stage studies (Phase 3 and Phase 4 combined) alongside 32 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Squamous Cell Carcinoma is led by H. Lee Moffitt Cancer Center and Research Institute with 3 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 48 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Squamous Cell Carcinoma?

PlainTrial tracks 48 US clinical trials for Squamous Cell Carcinoma, of which 17 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Squamous Cell Carcinoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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