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Squamous Cell Carcinoma
Open-data reference.
48 US clinical trials · 17 currently recruiting
Active & Recent Trials
Patient Preference for Subcutaneous vs. Intravenous Immune Therapy
Diwakar Davar
NCT07223424
Use of SPY Imaging System to Minimize Fistulas After Hypopharyngeal Reconstruction
Matthew Spector
NCT06831149
Radiotherapy With Cisplatin vs. Docetaxel-cetuximab in HNSCC: ERCC1 Biomarker Enrichment and Interaction Design
Christopher Wilke
NCT02128906
Treating Basal and Squamous Cell Carcinomas With Fractional Laser and Tirbanibulin Ointment
Bruce Robinson, MD
NCT07010692
Sentinel Lymph Node Biopsy for Cutaneous Squamous Cell Carcinoma of the Head and Neck
Indiana University
NCT05108090
T Cell Receptor Immunotherapy for Patients With Metastatic Non-Small Cell Lung Cancer
National Cancer Institute (NCI)
NCT02133196
Defining TRPV4 Contribution of Schwann Cells to Oral Cancer Pain
New York University
NCT07095608
Neoadjuvant Chemotherapy and Programmed Cell Death Protein 1(PD-1) Inhibition for Head and Neck Cancer Treatment De-escalation (NeoScorch HN)
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
NCT07209189
Preoperative Immunotherapy in Patients With Squamous Cell Carcinoma of the Head and Neck
Alain Algazi
NCT03708224
Immunotherapy With Chemotherapy and Chemoradiation for Advanced Squamous Cancer of Nasal Cavity / Paranasal Sinuses (I-NAPA)
M.D. Anderson Cancer Center
NCT05027633
A Clinical Study of Intratumoral MVR-T3011 (T3011) Given as a Single Agent and in Combination With Intravenous Pembrolizumab in Participants With Advanced or Metastatic Solid Tumors
ImmVira Pharma Co.
NCT04370587
Intratumoral Lidocaine Injection Before Oropharyngeal Cancer Surgery
Ryan Carey
NCT06747390
Phase 2 Trial of Neoadjuvant and Adjuvant Tiragolumab Plus Atezolizumab in Patients With Newly Diagnosed PD-L1 CPS Positive Resectable Stage 3-4 Oral Cavity Squamous Cell Carcinoma (OCSCC).
M.D. Anderson Cancer Center
NCT05681039
Study of Afatinib in Advanced Cutaneous Squamous Cell Carcinoma
H. Lee Moffitt Cancer Center and Research Institute
NCT05070403
Toripalimab With Chemotherapy for Sinus Cancer
Glenn J. Hanna
NCT06940180
Raman Spectroscopy and Skin Cancer
Renee Farrell
NCT06384924
Impact of COL7A1 Gene Therapy on SCC Recurrence in RDEB Skin
Stanford University
NCT06731933
De-intensified Radiation Therapy With Chemotherapy (Cisplatin) or Immunotherapy (Nivolumab) in Treating Patients With Early-Stage, HPV-Positive, Non-Smoking Associated Oropharyngeal Cancer
National Cancer Institute (NCI)
NCT03952585
TORS De-Intensification Protocol Version 2.0: Dose and Volume Reduction in the Neck
Abramson Cancer Center at Penn Medicine
NCT03729518
Analyzing Clinical Outcomes and Genomic Data of American Indian Patient Population
University of Oklahoma
NCT05863052
Quercetin Chemoprevention for Squamous Cell Carcinoma in Patients With Fanconi Anemia
Children's Hospital Medical Center, Cincinnati
NCT03476330
Nivolumab and BMS986205 in Treating Patients With Stage II-IV Squamous Cell Cancer of the Head and Neck
Thomas Jefferson University
NCT03854032
Comparing Two Surveillance Approaches for People Who Have Received Treatment for HPV-associated Head and Neck Cancer and Show No Signs of Disease
Memorial Sloan Kettering Cancer Center
NCT05048459
A Study of Radiation Therapy and Cemiplimab for People With Skin Cancer
Memorial Sloan Kettering Cancer Center
NCT05574101
Neoadjuvant Study of PD-1 Inhibitor Pembrolizumab in PD-1 Naive Cutaneous Squamous Cell Carcinoma (cSCC)
Diwakar Davar
NCT04808999
Phase 2 Trial of Adaptive Radiotherapy Boost for HNSCC
H. Lee Moffitt Cancer Center and Research Institute
NCT06137274
Neo-adjuvant Treatment for Squamous Cell Carcinoma Using Direct Tumor Injection With RP1.
Sherrif Ibrahim
NCT05858229
1922GCCC: Pembro and Bavituximab for Squamous Cell Carcinoma of Head and Neck
University of Maryland, Baltimore
NCT04150900
DERM US and EU Validation Study
Skin Analytics Limited
NCT05126173
Observational Study of Swallowing Function After Treatment of Advanced Laryngeal Cancer
University of Minnesota
NCT01089803
Electronic Brachytherapy for the Treatment of NMSC
Xoft
NCT01016899
Does Cryofixation of Skin Specimens Affect Quality of Subsequent Formalin Fixed Paraffin Embedded H and E Histology
Abramson Cancer Center at Penn Medicine
NCT01540695
A Study of DKN-01 in Combination With Paclitaxel or Pembrolizumab
Leap Therapeutics
NCT02013154
A Phase 1 Study in Participants With Advanced Cancer
Eli Lilly and Company
NCT01115790
Safety and Efficacy of Oral Midazolam for Perioperative Anxiety Relief of Patients Undergoing Mohs Micrographic Surgery
Mayo Clinic
NCT00578214
Pembrolizumab in Combination With CRT for LA-SCCHN
Sanford Health
NCT02586207
Vaccine Treatment for Advanced Non-Small Cell Lung Cancer
NewLink Genetics Corporation
NCT00073398
Reflectance Confocal Microscopy of Wounds During Moh's Surgery: Feasibility Testing of a Mosaicing Algorithm for Intraoperative Imaging of Cancer Margins
Memorial Sloan Kettering Cancer Center
NCT01872130
Photochemical Tissue Bonding
Massachusetts General Hospital
NCT00586040
A Pilot Study of Paclitaxel With Radiation Therapy for Locally Advanced Head and Neck Cancer
National Cancer Institute (NCI)
NCT00001442
De-Escalation Therapy for Human Papillomavirus Negative Disease
University of Chicago
NCT03944915
Combination Chemotherapy for Locally Advanced Squamous Cell Carcinoma of the Head and Neck
Dana-Farber Cancer Institute
NCT00139230
Videoscopic Versus Open Inguinal Lymphadenectomy for Cancer
Emory University
NCT01526486
PET-MRI Assessment of Early Tumor Response to Predict Outcomes of HPV-Positive Oropharynx Cancer Patients
University of Wisconsin, Madison
NCT03342378
Study Evaluating Temsirolimus in Advanced Stage Squamous Cell Carcinoma of the Head & Neck
Wyeth is now a wholly owned subsidiary of Pfizer
NCT00195299
IRX-2 Regimen Combined With Nivolumab in Recurrent/Metastatic Solid Tumors
H. Lee Moffitt Cancer Center and Research Institute
NCT03758781
Radiation and Cetuximab Plus Intratumoral EGFR Antisense DNA in Locally Advanced Head and Neck Squamous Cell Carcinoma
The University of Texas Health Science Center at San Antonio
NCT01592721
Fluorine F 18 EF5 Positron Emission Tomography in Assessing Hypoxia in Patients With Newly Diagnosed Stage I, Stage II, Stage III, or Stage IV Head or Neck Squamous Cell Cancer of the Oral Cavity, Oropharynx, and Larynx
Abramson Cancer Center at Penn Medicine
NCT01020097
Phase Distribution
| Phase | Trial count |
|---|---|
| Early Phase 1 | 11 |
| Phase 2 | 21 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Squamous Cell Carcinoma Trial Landscape
ClinicalTrials.gov lists 48 US studies indexed under Squamous Cell Carcinoma, and 17 of those are currently open to recruitment — roughly 35% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Squamous Cell Carcinoma shows 0 late-stage studies (Phase 3 and Phase 4 combined) alongside 32 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Squamous Cell Carcinoma is led by H. Lee Moffitt Cancer Center and Research Institute with 3 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 48 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Squamous Cell Carcinoma?
PlainTrial tracks 48 US clinical trials for Squamous Cell Carcinoma, of which 17 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Squamous Cell Carcinoma?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.