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A Study of Radiation Therapy and Cemiplimab for People With Skin Cancer
NCT05574101 · View on ClinicalTrials.gov ↗
Study Summary
The purpose of the study is to see if the combination of radiation therapy and cemiplimab immunotherapy is an effective treatment for people with locally advanced, unresectable CSCC.
Conditions Studied
Interventions
- DRUG Cemiplimab
- RADIATION Radiotherapy
Study Locations (13)
New York
- Memorial Sloan Kettering Suffolk-Commack (All Protocol Activities) — Commack
- Memorial Sloan Kettering Westchester (All Protocol Activities) — Harrison
- Memorial Sloan Kettering Cancer Center (All Protocol Activities) — New York
- Memorial Sloan Kettering Nassau (All protocol activities) — Rockville Centre
New Jersey
- Memorial Sloan Kettering Cancer Center at Basking Ridge (All Protocol Activities) — Basking Ridge
- Memorial Sloan Kettering Monmouth (All Protocol Activities) — Middletown
- Memorial Sloan Kettering Bergen (All protocol activities) — Montvale
Colorado
- University of Colorado (Data Collection Only) — Aurora
Florida
- Moffitt Cancer Center (Data Collection Only) — Tampa
Ohio
- Cleveland Clinic (Data Collection Only) — Cleveland
Pennsylvania
- Fox Chase Cancer Center (Data Collection Only) — Philadelphia
South Carolina
- Medical University of South Carolina — Charleston
Washington
- University of Washington (Data Collection Only) — Seattle
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 34 participants |
| Start Date | 2022-10-06 |
| Est. Completion | 2026-10-06 |
| Phase | Phase 2 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05574101
The ClinicalTrials.gov registry entry for NCT05574101 describes a study currently listed as active not recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 34 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Memorial Sloan Kettering Cancer Center, which has 2,280 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 7 conditions, with Squamous Cell Carcinoma appearing as the primary indexed condition, and to 2 interventions — of which Cemiplimab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT05574101 reports 13 study locations spanning 8 distinct geographic areas — top geographies include New York, New Jersey, Colorado. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT05574101 about?
NCT05574101 is a clinical study titled "A Study of Radiation Therapy and Cemiplimab for People With Skin Cancer". The purpose of the study is to see if the combination of radiation therapy and cemiplimab immunotherapy is an effective treatment for people with locally advanced, unresectable CSCC.
What is the current status of trial NCT05574101?
This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 34 participants. The study started on 2022-10-06. Estimated completion is 2026-10-06.
What conditions does trial NCT05574101 study?
This clinical trial studies the following conditions: Squamous Cell Carcinoma, Skin Cancer, Cutaneous Squamous Cell Carcinoma, Locally Advanced Cutaneous Squamous Cell Carcinoma, Locally Advanced Squamous Cell Carcinoma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT05574101?
The interventions under investigation include: Cemiplimab (DRUG), Radiotherapy (RADIATION). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT05574101?
This trial is sponsored by Memorial Sloan Kettering Cancer Center, which has 2,280 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT05574101 being conducted?
This trial has 13 study locations across Colorado, Florida, New Jersey, New York, Ohio. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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