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ClinicalTrials.gov 43 recruiting now official registry

Solid Tumors clinical trials

43 of 127 indexed Solid Tumors trials are currently recruiting.

127 US clinical trials · 43 currently recruiting

Solid Tumors is the subject of 127 registered US clinical trials on ClinicalTrials.gov, 43 of them currently open to new participants. 4 are in Phase 3-4 (later-stage) and 117 in Phase 1-2 (earlier-stage). The most active sponsor is M.D. Anderson Cancer Center, running 8 of these trials.

The research picture

Solid Tumors has 127 registered US clinical trials, 43 of them open to new participants right now, about 34% of the total.

43
recruiting participants now
34%
of trials open to enrollment
4
in Phase 3–4 (later-stage)
8
top sponsor: M.D. Anderson Cancer Center
Phase 1102Phase 215Phase 33Phase 41

Active & Recent Trials

127 total, page 1 of 3

RECRUITING open-ended (no fixed target)

CIBMTR Research Database

Center for International Blood and Marrow Transplant Research

NCT01166009

RECRUITING Phase 3 3,500 participants

Long-term Safety and Efficacy Extension Study for Participants With Advanced Tumors Who Are Currently on Treatment or in Follow-up in a Pembrolizumab (MK-3475) Study (MK-3475-587/KEYNOTE-587)

Merck Sharp & Dohme

NCT03486873

RECRUITING 1,000 participants

PanTheR Registry Trial

RenovoRx

NCT06805461

RECRUITING Phase 2 920 participants

Tumor-agnostic Precision Immuno-oncology and Somatic Targeting Rational for You (TAPISTRY) Platform Study

Hoffmann-La Roche

NCT04589845

RECRUITING Phase 1 710 participants

A Study to Evaluate INCB161734 in Participants With Advanced or Metastatic Solid Tumors With KRAS G12D Mutation

Incyte Corporation

NCT06179160

RECRUITING Phase 1 604 participants

Study of INCB123667 in Subjects With Advanced Solid Tumors

Incyte Corporation

NCT05238922

RECRUITING Phase 2 497 participants

APL-101 Study of Subjects With NSCLC With c-Met EXON 14 Skip Mutations and c-Met Dysregulation Advanced Solid Tumors

Apollomics

NCT03175224

RECRUITING Phase 2 492 participants

DB-1311 in Combination With BNT327 or DB-1305 in Advanced/Metastatic Solid Tumors

DualityBio

NCT06953089

RECRUITING Phase 1 475 participants

A Study of HS-20110 in Participants With Advanced Solid Tumors

Hansoh BioMedical R&D Company

NCT06892379

RECRUITING Phase 1 408 participants

A Study to Evaluate the Safety of INCA33890 in Participants With Advanced or Metastatic Solid Tumors

Incyte Corporation

NCT05836324

RECRUITING Phase 1 385 participants

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Clinical Activity of GSK5733584 for Injection in Participants With Advanced Solid Tumors

GlaxoSmithKline

NCT06431594

RECRUITING Phase 1 362 participants

A Phase 1 Study of AB521 Monotherapy and Combination Therapies in Renal Cell Carcinoma and Other Solid Tumors

Arcus Biosciences

NCT05536141

RECRUITING Phase 1 350 participants

Study of ORIC-114 in Patients With Advanced Solid Tumors Harboring an EGFR or HER2 Alteration

ORIC Pharmaceuticals

NCT05315700

RECRUITING Phase 1 285 participants

Study of IBI3020 Treatment in Participants With Late-Stage Solid Tumors

Innovent Biopharmaceutical Technology (Hangzhou) Co.

NCT06963281

RECRUITING Phase 1 282 participants

S-531011 as Monotherapy and in Combination With an Immune Checkpoint Inhibitor in Advanced or Metastatic Solid Tumors

Shionogi

NCT05101070

RECRUITING Phase 1 280 participants

A Study to Evaluate INCA036873 in Participants With Advanced Solid Tumors and Hematological Malignancies

Incyte Corporation

NCT07195916

RECRUITING Phase 2 254 participants

A Study to Assess the Efficacy and Safety of FORE8394 in Participants With Cancer Harboring BRAF Alterations

Fore Biotherapeutics

NCT05503797

RECRUITING Phase 1 250 participants

QTX3034 in Patients With KRAS G12D Mutation

Quanta Therapeutics

NCT06227377

RECRUITING Phase 1 250 participants

Study of Anti-CEACAM5 ADC M9140 in Participants With Advanced Solid Tumors (PROCEADE PanTumor)

EMD Serono Research & Development Institute

NCT06710132

RECRUITING 200 participants

Genomic Profiling in Cancer Patients

Memorial Sloan Kettering Cancer Center

NCT01775072

RECRUITING Phase 1 190 participants

A Study to Test Different Doses of BI 1831169 Alone and in Combination With an Anti-PD-1 Antibody in People With Different Types of Advanced Cancer (Solid Tumors)

Boehringer Ingelheim

NCT05155332

RECRUITING Phase 1 180 participants

Phase 1a/b Study of ZL-6201 Safety, PK, and Preliminary Efficacy in Sarcoma and Selected Tumors

Zai Lab (Shanghai) Co.

NCT07374848

RECRUITING Phase 1 150 participants

A Study of XB371 Administered in Participants With Locally Advanced or Metastatic Solid Tumors

Exelixis

NCT07123103

RECRUITING Phase 1 150 participants

First-in-Human Trial of DS-2243a in Participants With Advanced Solid Tumors

Daiichi Sankyo

NCT06644755

RECRUITING Phase 1 144 participants

JAB-30355 in Patients With Advanced Solid Tumors Harboring TP53 Y220C Mutation

Jacobio Pharmaceuticals Co.

NCT06386146

RECRUITING Phase 1 130 participants

Study of AUBE00 in Patients With Solid Tumors

Chugai Pharmaceutical

NCT07030959

RECRUITING Phase 1 112 participants

A Study of ZL-1310 in Participants With Selected Solid Tumors

Zai Lab (Shanghai) Co.

NCT06885281

RECRUITING Phase 1 103 participants

A Study of GEN1106 in Participants With Solid Tumors

Genmab

NCT07416123

RECRUITING Phase 1 102 participants

JAB-2485 Activity in Adult Patients With Advanced Solid Tumors

Jacobio Pharmaceuticals Co.

NCT05490472

RECRUITING Phase 1 100 participants

Safety and Preliminary Anti-Tumor Activity of TYRA-430 in Advanced Hepatocellular Carcinoma and Other Solid Tumors With Activating FGF/FGFR Pathway Aberrations

Tyra Biosciences

NCT06915753

RECRUITING Phase 1 76 participants

ORIC-114 in Combination with Subcutaneous Amivantamab in Patients with EGFR Exon20 Insertion Mutant NSCLC

ORIC Pharmaceuticals

NCT06816992

RECRUITING Phase 1 68 participants

A Study of ADRX-0405 in Subjects With Select Advanced Solid Tumors

Adcentrx Therapeutics

NCT06710379

RECRUITING Phase 1 66 participants

A Study to Test How Different Doses of BI 1703880 in Combination With Ezabenlimab Are Tolerated in People With Different Types of Advanced Cancer (Solid Tumours)

Boehringer Ingelheim

NCT05471856

RECRUITING Phase 1 65 participants

ABL103 in Combination With Pembrolizumab, With or Without Taxane in Advanced or Metastatic Solid Tumors

ABL Bio

NCT07158918

RECRUITING Phase 1 65 participants

5-aza-4'-Thio-2'-Deoxycytidine (Aza-TdC) in People With Advanced Solid Tumors

National Cancer Institute (NCI)

NCT03366116

RECRUITING Phase 1 63 participants

A First-in-Human Study of BG-C0902 Alone and in Combination With Other Therapeutic Agents in Patients With Advanced Solid Tumors

BeOne Medicines

NCT07181681

RECRUITING Phase 1 54 participants

Phase 1 Dose Escalation and Expansion Study of TROP2 CAR Engineered IL15-transduced Cord Blood-derived NK Cells in Patients With Advanced Solid Tumors (TROPIKANA)

M.D. Anderson Cancer Center

NCT06066424

RECRUITING Phase 4 46 participants

The FLOTILLA Study: Providing Continued Access to The Study Medicines Encorafenib and Binimetinib for Participants in Prior Clinical Trials

Pfizer

NCT05203172

RECRUITING Phase 1 41 participants

Intratumoral Delivery of Viral Replicon (saRNA) Particles Expressing IL-12 in Head and Neck Cancer

VLP Therapeutics

NCT06736379

RECRUITING Phase 2 40 participants

A Study to Evaluate the Safety and Pharmacokinetics of Eflapegrastim in Pediatric Participants With Solid Tumors or Lymphomas and Treated With Myelosuppressive Chemotherapy

Spectrum Pharmaceuticals

NCT04570423

RECRUITING Phase 2 40 participants

Phase II Biomarker Study of SAR444881 in Combination With Cemiplimab in Solid Tumors

M.D. Anderson Cancer Center

NCT06651593

RECRUITING Phase 1 40 participants

DPTX3186 in Wnt Pathway Activated Solid Tumors

Dewpoint Therapeutics

NCT07312903

RECRUITING Phase 1 20 participants

Flavored, Oral Irinotecan VAL-413 (Orotecan®) Given With Temozolomide for Treatment of Recurrent Pediatric Solid Tumors

Valent Technologies

NCT04337177

ACTIVE NOT RECRUITING 14,266 participants

Mayo Clinic Radiotherapy Patient Outcomes Registry and Biobanking Study

Mayo Clinic

NCT02457962

ACTIVE NOT RECRUITING Phase 1 429 participants

GEN1046 Safety Trial in Patients With Malignant Solid Tumors

Genmab

NCT03917381

ACTIVE NOT RECRUITING Phase 2 300 participants

Study of Olaparib (MK-7339) in Combination With Pembrolizumab (MK-3475) in the Treatment of Homologous Recombination Repair Mutation (HRRm) and/or Homologous Recombination Deficiency (HRD)-Positive Advanced Cancer (MK-7339-007/KEYLYNK-007)

Merck Sharp & Dohme

NCT04123366

ACTIVE NOT RECRUITING Phase 1 253 participants

Phase 1-2 Study of ASTX660 in Subjects With Advanced Solid Tumors and Lymphomas

Taiho Oncology

NCT02503423

ACTIVE NOT RECRUITING Phase 3 205 participants

Avelumab Program Rollover Study

EMD Serono Research & Development Institute

NCT03815643

ACTIVE NOT RECRUITING Phase 1 195 participants

An Open-Label Dose-Escalation Study to Evaluate XmAb24306 as a Single Agent and in Combination With Atezolizumab in Participants With Locally Advanced or Metastatic Solid Tumors

Genentech

NCT04250155

ACTIVE NOT RECRUITING Phase 1 192 participants

A Study to Learn About the Study Medicine (Called PF-07220060 in Combination With PF-07104091) In Participants With Breast Cancer and Solid Tumors

Pfizer

NCT05262400

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Phase Distribution

PhaseTrial count
Phase 1 102
Phase 2 15
Phase 3 3
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Solid Tumors Trial Landscape

127 indexed Solid Tumors studies · 43 recruiting (34%).

Phase mix: 4 late (III/IV) vs 117 early (I/II).

Top sponsor: M.D. Anderson Cancer Center (8 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Solid Tumors?

PlainTrial tracks 127 US clinical trials for Solid Tumors, of which 43 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Solid Tumors?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.