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RECRUITING Phase 1

Study of INCB123667 in Subjects With Advanced Solid Tumors

NCT05238922 · View on ClinicalTrials.gov ↗

Study Summary

This is an open-label, dose-escalation and dose-expansion study to determine the safety, tolerability, PK, pharmacodynamics, and preliminary efficacy of INCB123667 when administered as monotherapy and in combination with anticancer therapies in participants with selected advanced or metastatic solid tumors. This study will consist of 2 parts. In Part 1, INCB123667 will be administered as monotherapy and in Part 2, INCB123667 will be administered in combination with anticancer therapies of interest. Each part will comprise a dose escalation portion (Parts 1a and 2a, respectively) and a dose-expansion portion (Parts 1b and 2b, respectively).

Conditions Studied

Interventions

  • DRUG Bevacizumab
  • DRUG Olaparib
  • DRUG Paclitaxel
  • DRUG Palbociclib
  • DRUG INCB0123667

Study Locations (20)

California

  • City of Hope Medical Center — Duarte
  • City of Hope-Lennar Foundation Cancer Center — Irvine
  • Valkyrie Clinical Trials — Los Angeles

New York

  • Memorial Sloan Kettering Cancer Center — New York
  • New York Presbyterian/Weill Cornell — New York
  • Ny Cancer and Blood Specialists — Shirley

Pennsylvania

  • University of Pennsylvania Abramson Cancer Center — Philadelphia
  • University of Pittsburgh Cancer Institute Cancer Services — Pittsburgh
  • Allegheny Health Network — Pittsburgh

Texas

  • Texas Oncology — Austin
  • Texas Oncology-Fort Worth South Henderson — Fort Worth

Colorado

  • Rocky Mountain Cancer Centers-Sky Ridge — Lone Tree

Connecticut

  • Yale Cancer Center — New Haven

Florida

  • Mount Sinai Medical Center Comprehensive Cancer Center — Miami Beach

Georgia

  • Emory University — Atlanta

Trial Details

FieldValue
Enrollment Target 604 participants
Start Date 2022-07-05
Est. Completion 2027-08-31
Phase Phase 1

Sponsor

Incyte Corporation

163 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT05238922

The ClinicalTrials.gov registry entry for NCT05238922 describes a study currently listed as recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 604 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Incyte Corporation, which has 163 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Solid Tumors appearing as the primary indexed condition, and to 5 interventions — of which Bevacizumab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT05238922 reports 20 study locations spanning 13 distinct geographic areas — top geographies include California, New York, Pennsylvania. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT05238922 about?

NCT05238922 is a clinical study titled "Study of INCB123667 in Subjects With Advanced Solid Tumors". This is an open-label, dose-escalation and dose-expansion study to determine the safety, tolerability, PK, pharmacodynamics, and preliminary efficacy of INCB123667 when administered as monotherapy and in combination with anticancer therapies in participants with selected advanced or metastatic solid...

What is the current status of trial NCT05238922?

This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 604 participants. The study started on 2022-07-05. Estimated completion is 2027-08-31.

What conditions does trial NCT05238922 study?

This clinical trial studies the following conditions: Solid Tumors. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT05238922?

The interventions under investigation include: Bevacizumab (DRUG), Olaparib (DRUG), Paclitaxel (DRUG), Palbociclib (DRUG), INCB0123667 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT05238922?

This trial is sponsored by Incyte Corporation, which has 163 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT05238922 being conducted?

This trial has 20 study locations across California, Colorado, Connecticut, Florida, Georgia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial