Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT02503423 · ClinicalTrials.gov registry record · Phase 1
Phase 1-2 Study of ASTX660 in Subjects With Advanced Solid Tumors and Lymphomas
A Phase 1 study of Lymphoma and Solid Tumors, sponsored by Taiho Oncology.
- Active
- Registry status
- Phase 1
- Development phase
- 253
- Enrollment target
- 20
- Study locations
NCT02503423 is a Phase 1 study of Lymphoma and Solid Tumors that is active but no longer recruiting, run by Taiho Oncology. The registered enrollment target is 253 participants, below the 483-participant average among 299 other Lymphoma trials with a reported enrollment target (48% lower). The trial reports 20 study locations across 13 states.
The verdict
NCT02503423, a Phase 1 study of Lymphoma and Solid Tumors, is active but no longer recruiting, sponsored by Taiho Oncology.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 1
- Development phase
- 253 participants
- Enrollment target
- 20
- Study locations
Study Summary
This is an open-label, dose-escalation Phase 1/2 study to assess the safety of ASTX660, determine the maximum tolerated dose (MTD), recommended Phase 2 dose (RP2D), and recommended dosing regimen, and to obtain preliminary efficacy, pharmacokinetic (PK), and target engagement data, in subjects with advanced solid tumors or lymphoma for whom standard life-prolonging measures are not available.
Conditions Studied
Interventions
- DRUG ASTX660
Study Locations (20)
New York
- Roswell Park Cancer Institute - Buffalo
- New York University Langone Medical Center - New York
- New York Presbyterian Hospital Columbia University Medical Center - New York
- Icahn School of Medicine at Mount Sinai - New York
- Rochester Skin Lymphoma Medical Group - Rochester
California
- USC/Norris Comprehensive Cancer Center - Los Angeles
- Cedars-Sinai Medical Center - Los Angeles
- UC Davis Medical Center - Sacramento
Massachusetts
- Tufts Medical Center - Boston
- Dana-Farber Cancer Institute - Boston
Alabama
- University of Alabama at Birmingham - Birmingham
Arizona
- HonorHealth Research Institute - Scottsdale
Connecticut
- Simlow Cancer Hospital at Yale - New Haven
Georgia
- Emory University winship Cancer Institute - Atlanta
Illinois
- Robert H. Lurie Comprehensive Cancer Center of Northwestern University - Chicago
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 253 participants |
| Start Date | 2015-07-14 |
| Est. Completion | 2027-12 |
| Phase | Phase 1 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT02503423
The ClinicalTrials.gov registry entry for NCT02503423 describes a study currently listed as active not recruiting, categorized as Phase 1. The registered enrollment target is 253 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 483-participant average among 299 other Lymphoma trials with a reported enrollment target (48% lower). The listed sponsor is Taiho Oncology, which has 52 total studies on file at ClinicalTrials.gov.
The record links to 2 conditions, with Lymphoma appearing as the primary indexed condition, and to 1 intervention - of which ASTX660 is the first listed.
NCT02503423 reports 20 study locations spanning 13 distinct geographic areas - top geographies include New York, California, Massachusetts.
Frequently Asked Questions
What is clinical trial NCT02503423 about?
NCT02503423 is a clinical study titled "Phase 1-2 Study of ASTX660 in Subjects With Advanced Solid Tumors and Lymphomas". This is an open-label, dose-escalation Phase 1/2 study to assess the safety of ASTX660, determine the maximum tolerated dose (MTD), recommended Phase 2 dose (RP2D), and recommended dosing regimen, and to obtain preliminary efficacy, pharmacokinetic (PK), and target engagement data, in subjects with ...
What is the current status of trial NCT02503423?
This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 253 participants. The study started on 2015-07-14. Estimated completion is 2027-12.
What conditions does trial NCT02503423 study?
This clinical trial studies the following conditions: Lymphoma, Solid Tumors.
What interventions are being tested in trial NCT02503423?
The interventions under investigation include: ASTX660 (DRUG).
Who is sponsoring clinical trial NCT02503423?
This trial is sponsored by Taiho Oncology, which has 52 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT02503423 being conducted?
This trial has 20 study locations across Alabama, Arizona, California, Connecticut, Georgia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Lymphoma
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
-
A Phase 1/2, Open-label Study of Valemetostat in Combination With Rituximab and Lenalidomide in Relapsed or Refractory Follicular Lymphoma
RECRUITING · Phase 1
-
TLN-121 in Relapsed or Refractory Non-Hodgkin Lymphomas
RECRUITING · Phase 1
-
Cytotoxic T-Lymphocytes for EBV-positive Lymphoma, GRALE
RECRUITING · Phase 1
-
CAR T-cell Therapy Directed to CD70 for Pediatric Patients With Hematological Malignancies
RECRUITING · Phase 1
-
CRISPR-Edited Allogeneic Anti-CD19 CAR-T Cell Therapy for Relapsed/Refractory B Cell Non-Hodgkin Lymphoma (ANTLER)
RECRUITING · Phase 1
-
A Study of TLN-254 in Participants With Relapsed or Refractory T-cell Lymphoma
RECRUITING · Phase 1
Read our methodology - how this data is sourced, computed, and verified.
Related
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.