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ACTIVE NOT RECRUITING Phase 1

Phase 1-2 Study of ASTX660 in Subjects With Advanced Solid Tumors and Lymphomas

NCT02503423 · View on ClinicalTrials.gov ↗

Study Summary

This is an open-label, dose-escalation Phase 1/2 study to assess the safety of ASTX660, determine the maximum tolerated dose (MTD), recommended Phase 2 dose (RP2D), and recommended dosing regimen, and to obtain preliminary efficacy, pharmacokinetic (PK), and target engagement data, in subjects with advanced solid tumors or lymphoma for whom standard life-prolonging measures are not available.

Conditions Studied

Interventions

  • DRUG ASTX660

Study Locations (20)

New York

  • Roswell Park Cancer Institute — Buffalo
  • New York University Langone Medical Center — New York
  • New York Presbyterian Hospital Columbia University Medical Center — New York
  • Icahn School of Medicine at Mount Sinai — New York
  • Rochester Skin Lymphoma Medical Group — Rochester

California

  • USC/Norris Comprehensive Cancer Center — Los Angeles
  • Cedars-Sinai Medical Center — Los Angeles
  • UC Davis Medical Center — Sacramento

Massachusetts

  • Tufts Medical Center — Boston
  • Dana-Farber Cancer Institute — Boston

Alabama

  • University of Alabama at Birmingham — Birmingham

Arizona

  • HonorHealth Research Institute — Scottsdale

Connecticut

  • Simlow Cancer Hospital at Yale — New Haven

Georgia

  • Emory University winship Cancer Institute — Atlanta

Illinois

  • Robert H. Lurie Comprehensive Cancer Center of Northwestern University — Chicago

Trial Details

FieldValue
Enrollment Target 253 participants
Start Date 2015-07-14
Est. Completion 2027-12
Phase Phase 1

Sponsor

Taiho Oncology

46 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT02503423

The ClinicalTrials.gov registry entry for NCT02503423 describes a study currently listed as active not recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 253 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Taiho Oncology, which has 46 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 2 conditions, with Lymphoma appearing as the primary indexed condition, and to 1 intervention — of which ASTX660 is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT02503423 reports 20 study locations spanning 13 distinct geographic areas — top geographies include New York, California, Massachusetts. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT02503423 about?

NCT02503423 is a clinical study titled "Phase 1-2 Study of ASTX660 in Subjects With Advanced Solid Tumors and Lymphomas". This is an open-label, dose-escalation Phase 1/2 study to assess the safety of ASTX660, determine the maximum tolerated dose (MTD), recommended Phase 2 dose (RP2D), and recommended dosing regimen, and to obtain preliminary efficacy, pharmacokinetic (PK), and target engagement data, in subjects with ...

What is the current status of trial NCT02503423?

This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 253 participants. The study started on 2015-07-14. Estimated completion is 2027-12.

What conditions does trial NCT02503423 study?

This clinical trial studies the following conditions: Lymphoma, Solid Tumors. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT02503423?

The interventions under investigation include: ASTX660 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT02503423?

This trial is sponsored by Taiho Oncology, which has 46 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT02503423 being conducted?

This trial has 20 study locations across Alabama, Arizona, California, Connecticut, Georgia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial