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NCT04589845 · ClinicalTrials.gov registry record · Phase 2
Tumor-agnostic Precision Immuno-oncology and Somatic Targeting Rational for You (TAPISTRY) Platform Study
A Phase 2 study of Solid Tumors, sponsored by Hoffmann-La Roche.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 920
- Enrollment target
- 20
- Study locations
NCT04589845: Recruiting Phase 2 study of Solid Tumors, sponsored by Hoffmann-La Roche.
NCT04589845 is a Phase 2 study of Solid Tumors that is actively recruiting participants, run by Hoffmann-La Roche. The registered enrollment target is 920 participants, above the 277-participant average among 125 other Solid Tumors trials with a reported enrollment target (232% higher). The trial reports 20 study locations across 12 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04589845, a Phase 2 study of Solid Tumors, is actively recruiting participants, sponsored by Hoffmann-La Roche.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 920 participants
- Enrollment target
- 20
- Study locations
Study Summary
TAPISTRY is a Phase II, global, multicenter, open-label, multi-cohort study designed to evaluate the safety and efficacy of targeted therapies or immunotherapy as single agents or in rational, specified combinations in participants with unresectable, locally advanced or metastatic solid tumors determined to harbor specific oncogenic genomic alterations or who are tumor mutational burden (TMB)-high as identified by a validated next-generation sequencing (NGS) assay. Participants with solid tumors will be treated with a drug or drug regimen tailored to their NGS assay results at screening. Participants will be assigned to the appropriate cohort based on their genetic alteration(s). Treatment will be assigned on the basis of relevant oncogenotype, will have cohort-specific inclusion/exclusion criteria, and, unless otherwise specified, will continue until disease progression, loss of clinical benefit, unacceptable toxicity, participant or physician decision to discontinue, or death, whichever occurs first.
Primary Outcome
Confirmed objective response indicates ≥4 weeks after initial documentation of response.
Conditions Studied
Interventions
- DRUG Atezolizumab
- DRUG Ipatasertib
- DRUG Alectinib
- DRUG Entrectinib
Study Locations (20)
California
- City of Hope National Medical Center - Duarte
- Kaiser Permanente Los Angeles - Los Angeles
- USC Norris Cancer Center - Los Angeles
- Hoag Memorial Hospital - Newport Beach
- UC Davis Comprehensive Cancer Center - Sacramento
- University of California at San Francisco - San Francisco
- Sarcoma Oncology Center - Santa Monica
Florida
- University of Florida - Gainesville
- Miami Cancer Institute of Baptist Health, Inc. - Miami
- Ocala Oncology Center - Ocala
Alabama
- Southern Cancer Center - Daphne
Arizona
- Western Regional Medical Center at Cancer Treatment Centers of America - Goodyear
Colorado
- Children's Hospital Colorado - Aurora
Delaware
- Christiana Care Health Srvcs - Newark
Georgia
- University Cancer & Blood Center, LLC - Athens
Idaho
- St. Alphonsus - Boise
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 920 participants |
| Start Date | 2021-01-18 |
| Est. Completion | 2032-09-25 |
| Phase | Phase 2 |
What NCT04589845 shows while recruiting
NCT04589845 is an interventional study that assigns participants to a tested intervention. The registered 920 participants enrollment target is mid-sized for trials with a published cap, above the 277-participant average among 125 other Solid Tumors trials with a reported enrollment target (232% higher).
The record links to 1 condition, with Solid Tumors appearing as the primary indexed condition, and to 4 interventions - of which Atezolizumab is the first listed.
NCT04589845 names 20 study sites across 12 states, led by California, Florida, Alabama.
Frequently Asked Questions
What is clinical trial NCT04589845 about?
NCT04589845 is a clinical study titled "Tumor-agnostic Precision Immuno-oncology and Somatic Targeting Rational for You (TAPISTRY) Platform Study". TAPISTRY is a Phase II, global, multicenter, open-label, multi-cohort study designed to evaluate the safety and efficacy of targeted therapies or immunotherapy as single agents or in rational, specified combinations in participants with unresectable, locally advanced or metastatic solid tumors deter...
What is the current status of trial NCT04589845?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 920 participants. The study started on 2021-01-18. Estimated completion is 2032-09-25.
What conditions does trial NCT04589845 study?
This clinical trial studies the following conditions: Solid Tumors.
What interventions are being tested in trial NCT04589845?
The interventions under investigation include: Atezolizumab (DRUG), Ipatasertib (DRUG), Alectinib (DRUG), Entrectinib (DRUG).
Who is sponsoring clinical trial NCT04589845?
This trial is sponsored by Hoffmann-La Roche, which has 909 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04589845 being conducted?
This trial has 20 study locations across Alabama, Arizona, California, Colorado, Delaware. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Solid Tumors
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04589845's enrollment target sits among peer trials
920 4th of 125 higher than 122 of 125 other Solid Tumors trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Solid Tumors trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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