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The FLOTILLA Study: Providing Continued Access to The Study Medicines Encorafenib and Binimetinib for Participants in Prior Clinical Trials
NCT05203172 · View on ClinicalTrials.gov ↗
Study Summary
The purpose of this clinical trial (called the FLOTILLA study) is to give continued access to the study medicines, as well as safety follow-up, for participants in prior clinical trials of encorafenib and/or binimetinib. All participants who took part in earlier encorafenib and/or binimetinib studies may participate the FLOTILLA study if they are still benefiting from the use of the study medicines. This will be determined by the study doctor. People may not participate in the FLOTILLA study if they have not enrolled in a prior study of encorafenib or binimetinib. Participants that had enrolled but had stopped receiving the study treatment in a prior study cannot enrolled in this study. Participants in the FLOTILLA study will receive encorafenib and/or binimetinib at the same dose and frequency as in their prior study, for up to about 5 years.
Conditions Studied
Interventions
- DRUG Binimetinib only treatment
- DRUG Encorafenib only Treatment
- DRUG Encorafenib & Binimetinib Treatment
- DRUG Treatment of Encorafenib & Binimetinib & Ribociclib
- DRUG Treatment of Encorafenib & Binimetinib & Cetuximab
Study Locations (20)
Georgia
- Emory University Hospital Midtown — Atlanta
- Emory University Hospital — Atlanta
- Investigational Drug Service Emory University Clinic — Atlanta
- Winship Cancer Institute of Emory University — Atlanta
Missouri
- Siteman Cancer Center — St Louis
- Barnes-Jewish Hospital — St Louis
- Washington University School of Medicine — St Louis
- Washington University — St Louis
Minnesota
- HealthPartners Cancer Research Center — Saint Paul
- Regions Hospital Pharmacy — Saint Paul
- HealthPartners Specialty Center — Saint Paul
Arizona
- St. Joseph's Hospital and Medical Center — Phoenix
- St. Joseph's Hospital and Medical Center — Phoenix
New York
- Rockefeller Outpatient Pavilion (53rd Street) — New York
- Memorial Sloan Kettering Cancer Center — New York
North Carolina
- Duke Cancer Center — Durham
- Investigational Chemotherapy Service — Durham
Massachusetts
- Massachusetts General Hospital — Boston
New Jersey
- MSK Basking Ridge — Basking Ridge
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 46 participants |
| Start Date | 2022-07-05 |
| Est. Completion | 2029-07-31 |
| Phase | Phase 4 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05203172
The ClinicalTrials.gov registry entry for NCT05203172 describes a study currently listed as recruiting. It is categorized as Phase 4, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 46 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Pfizer, which has 769 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Solid Tumors appearing as the primary indexed condition, and to 5 interventions — of which Binimetinib only treatment is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT05203172 reports 20 study locations spanning 9 distinct geographic areas — top geographies include Georgia, Missouri, Minnesota. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT05203172 about?
NCT05203172 is a clinical study titled "The FLOTILLA Study: Providing Continued Access to The Study Medicines Encorafenib and Binimetinib for Participants in Prior Clinical Trials". The purpose of this clinical trial (called the FLOTILLA study) is to give continued access to the study medicines, as well as safety follow-up, for participants in prior clinical trials of encorafenib and/or binimetinib. All participants who took part in earlier encorafenib and/or binimetinib studi...
What is the current status of trial NCT05203172?
This trial is currently recruiting. It is a Phase 4 study. The enrollment target is 46 participants. The study started on 2022-07-05. Estimated completion is 2029-07-31.
What conditions does trial NCT05203172 study?
This clinical trial studies the following conditions: Solid Tumors. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT05203172?
The interventions under investigation include: Binimetinib only treatment (DRUG), Encorafenib only Treatment (DRUG), Encorafenib & Binimetinib Treatment (DRUG), Treatment of Encorafenib & Binimetinib & Ribociclib (DRUG), Treatment of Encorafenib & Binimetinib & Cetuximab (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT05203172?
This trial is sponsored by Pfizer, which has 769 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT05203172 being conducted?
This trial has 20 study locations across Arizona, Georgia, Massachusetts, Minnesota, Missouri. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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