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ClinicalTrials.gov 20 recruiting now official registry

Soft Tissue Sarcoma clinical trials

Every US clinical trial registered for Soft Tissue Sarcoma — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.

54 US clinical trials · 20 currently recruiting

The research picture

Soft Tissue Sarcoma has 54 registered US clinical trials, 20 of them open to new participants right now — about 37% of the total.

20
recruiting participants now
37%
of trials open to enrollment
1
in Phase 3–4 (later-stage)
4
top sponsor: Memorial Sloan Kettering Cancer Center

Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.

Active & Recent Trials

RECRUITING Phase 3 300 participants

Study of ADI-PEG 20 or Placebo Plus Gem and Doc in Previously Treated Subjects With Leiomyosarcoma (ARGSARC)

Polaris Group

NCT05712694

RECRUITING Phase 1 158 participants

A Study Evaluating the Safety, Pharmacokinetics and Early Efficacy of AVA6000 in Solid Tumours

Avacta Life Sciences

NCT04969835

RECRUITING Phase 1 98 participants

Retifanlimab (Anti-PD-1 Antibody) With Gemcitabine and Docetaxel in Patients With Advanced Soft Tissue Sarcoma

Memorial Sloan Kettering Cancer Center

NCT04577014

RECRUITING Phase 2 75 participants

5-Day Preoperative Radiation for Soft Tissue Sarcoma

Stanford University

NCT06087861

RECRUITING NA 60 participants

Study Assessing the Effects of Early Psychiatric Referral on Mental Health and Quality of Life in People With Sarcoma

Memorial Sloan Kettering Cancer Center

NCT06129903

RECRUITING 50 participants

Genomic Risk in Retroperitoneal Sarcoma

Fox Chase Cancer Center

NCT06436846

RECRUITING Phase 2 50 participants

SATURN-STS: Phase II Study of Neoadjuvant Atezolizumab With Doxorubicin, Concurrent Atezolizumab With Pre-operative Radiation Therapy and Adjuvant Atezolizumab in Patients With High-risk Surgically Resectable Extremity and Truncal Soft Tissue Sarcoma

M.D. Anderson Cancer Center

NCT07049848

RECRUITING 50 participants

Evaluation of Tumor Resection Guided by Intraoperative Indocyanine Green Dye Fluorescence Angiography in Patients With Sarcoma

Mayo Clinic

NCT06409013

RECRUITING Phase 2 44 participants

Abemaciclib for Bone and Soft Tissue Sarcoma With Cyclin-Dependent Kinase (CDK) Pathway Alteration

Medical College of Wisconsin

NCT04040205

RECRUITING Phase 1 40 participants

Study of Autologous Tumor-Infiltrating Lymphocytes in Pediatric, Adolescent, and Young Adult Participants

Iovance Biotherapeutics

NCT06566092

RECRUITING Phase 2 40 participants

A Clinical Study to Investigate the Efficacy of Intratumoral Tigilanol Tiglate in Soft Tissue Sarcoma

QBiotics Group Limited

NCT05755113

RECRUITING Phase 2 40 participants

Preoperative 5-Day Radiotherapy for Soft Tissue Sarcoma

Medical University of South Carolina

NCT06905132

RECRUITING Phase 1 40 participants

A First-In-Human Phase 1 Trial of T-Cell Membrane-Anchored Tumor Targeted Il12 (Attil12)- T-Cell Therapy in Subjects With Advanced/Metastatic Soft Tissue and Bone Sarcoma

M.D. Anderson Cancer Center

NCT05621668

RECRUITING NA 40 participants

Pre-operative Hypofractionated Proton Therapy

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT05917301

RECRUITING NA 30 participants

Individualized Prehabilitation for Enhancing Recovery and Surgical Outcomes in Patients Undergoing Radiotherapy and Surgery for Soft Tissue Sarcoma

Mayo Clinic

NCT05526417

RECRUITING Phase 2 30 participants

Hypofractionated vs Conventional Fractionated RT in Soft Tissue Sarcomas

University of Wisconsin, Madison

NCT05109494

RECRUITING NA 30 participants

68Ga-DOTATATE PET/CT for the Diagnosis of Soft Tissue Sarcomas

Ohio State University Comprehensive Cancer Center

NCT06500065

RECRUITING Phase 1 25 participants

HER2 Chimeric Antigen Receptor (CAR) T Cells in Combination With Checkpoint Blockade in Patients With Advanced Sarcoma

Baylor College of Medicine

NCT04995003

RECRUITING NA 24 participants

Exercise and Soft Tissue Sarcoma

Duke University

NCT04921917

RECRUITING Phase 1 18 participants

Novel RNA-lipid Particle (RNA-LP) Vaccine for Anti-PD-1 Antibody Therapy Sensitization

University of Florida

NCT05264974

ACTIVE NOT RECRUITING NA 310 participants

Surveillance AFter Extremity Tumor surgerY

McMaster University

NCT03944798

ACTIVE NOT RECRUITING Phase 2 202 participants

Radiation Therapy to Treat Musculoskeletal Tumors

St. Jude Children's Research Hospital

NCT00186992

ACTIVE NOT RECRUITING Phase 2 65 participants

Dose Reduction of Postoperative Radiation for Soft Tissue Sarcoma of the Arms and Legs

Memorial Sloan Kettering Cancer Center

NCT04288375

ACTIVE NOT RECRUITING Phase 1 56 participants

Evaluation of AL3818 in Combination With Nivolumab in Solid Tumors

Sarcoma Oncology Research Center

NCT04165330

ACTIVE NOT RECRUITING Phase 2 48 participants

Hypofractionated Radiotherapy for Soft Tissue Sarcomas

University of Wisconsin, Madison

NCT03972930

ACTIVE NOT RECRUITING Phase 2 48 participants

Phase II Trial of Ribociclib and Everolimus in Advanced Dedifferentiated Liposarcoma (DDL) and Leiomyosarcoma (LMS)

Fox Chase Cancer Center

NCT03114527

ACTIVE NOT RECRUITING Phase 1 42 participants

Intratumoral Injection of IP-001 Following Thermal Ablation in Patients With CRC, NSCLC, and STS

Immunophotonics

NCT05688280

ACTIVE NOT RECRUITING Phase 2 40 participants

Talimogene Laherparepvec and Radiation Therapy in Treating Patients With Newly Diagnosed Soft Tissue Sarcoma That Can Be Removed by Surgery

National Cancer Institute (NCI)

NCT02923778

ACTIVE NOT RECRUITING Phase 1 36 participants

A Study of Oral LOXO-292 (Selpercatinib) in Pediatric Participants With Advanced Solid or Primary Central Nervous System (CNS) Tumors

Eli Lilly and Company

NCT03899792

ACTIVE NOT RECRUITING Early Phase 1 30 participants

Gemcitabine Plus Ascorbate for Sarcoma in Adults (Pilot)

University of Iowa

NCT04634227

ACTIVE NOT RECRUITING Phase 2 27 participants

APX005M and Doxorubicin in Advanced Sarcoma

Alexander Z. Wei, MD

NCT03719430

ACTIVE NOT RECRUITING 24 participants

Study to Assess TOPO2A as a Biomarker for Sensitivity to Doxorubicin/Doxil in Soft Tissue Sarcoma

Fox Chase Cancer Center

NCT04055753

ACTIVE NOT RECRUITING NA 16 participants

Feasibility Trial of Preoperative 5-Day Hypofractionated Radiotherapy for Primary Soft Tissue Sarcoma

Medical University of South Carolina

NCT05776667

ACTIVE NOT RECRUITING Phase 2 16 participants

A Study of Etrumadenant and Zimberelimab in People With Dedifferentiated Liposarcoma

Memorial Sloan Kettering Cancer Center

NCT05886634

ACTIVE NOT RECRUITING Phase 1 14 participants

In Situ Immunomodulation With CDX-301, Radiation Therapy, CDX-1140 and Poly-ICLC in Patients w/ Unresectable and Metastatic Solid Tumors

University of Southern California

NCT04616248

ACTIVE NOT RECRUITING Phase 1 8 participants

TVEC and Preop Radiation for Sarcoma (8 ml Dose)

John Rieth

NCT04599062

ACTIVE NOT RECRUITING Phase 1 6 participants

Neoadjuvant ADI-PEG 20 + Ifosfamide + Radiotherapy in Soft Tissue Sarcoma

Washington University School of Medicine

NCT05813327

ACTIVE NOT RECRUITING Phase 2 2 participants

Neoadjuvant Intralesional Injection of Talimogene Laherparepvec

John Rieth

NCT06660810

ACTIVE NOT RECRUITING Phase 1 2 participants

Dose Finding Study of L19TNF and Doxorubicin in Patients With STS

Philogen S.p.A.

NCT04032964

COMPLETED Phase 2 597 participants

Phase II Study of Brivanib (BMS-582664) to Treat Multiple Tumor Types

Bristol-Myers Squibb

NCT00633789

COMPLETED Phase 1 310 participants

A Study of Olaratumab (LY3012207) in Participants With Advanced Soft Tissue Sarcoma

Eli Lilly and Company

NCT02659020

COMPLETED Phase 1 229 participants

A Study of LY2880070 in Participants With Advanced or Metastatic Cancer

Esperas Pharma

NCT02632448

COMPLETED Phase 2 144 participants

SARC028: A Phase II Study of the Anti-PD1 Antibody Pembrolizumab (MK-3475) in Patients With Advanced Sarcomas

Sarcoma Alliance for Research through Collaboration

NCT02301039

COMPLETED Phase 2 98 participants

ADI-PEG 20 in Combination With Gemcitabine and Docetaxel for the Treatment of Soft Tissue Sarcoma, Osteosarcoma, Ewing's Sarcoma, and Small Cell Lung Cancer

Washington University School of Medicine

NCT03449901

COMPLETED Phase 1 71 participants

Study of the Safety, Pharmacokinetics and Efficacy of Tinostamustine in Patients With Advanced Solid Tumors.

Mundipharma Research Limited

NCT03345485

COMPLETED 49 participants

Biomarker Differences in Samples From Patients With Undifferentiated Sarcomas

Children's Oncology Group

NCT01802125

COMPLETED Phase 1 47 participants

Bevacizumab, Chemotherapy and Valproic Acid in Advanced Sarcomas

Mohammed M Milhem

NCT01106872

COMPLETED Phase 2 30 participants

Ipilimumab + Nivolumab + Cryotherapy in Metastatic or Locally Advanced Soft Tissue Sarcoma

Kristen Ganjoo

NCT04118166

COMPLETED Phase 1 30 participants

TVEC and Preop Radiation for Sarcoma (4 ml Dose)

University of Iowa

NCT02453191

COMPLETED Phase 1 27 participants

Phase I Dose-Escalation Study Of Azacitidine In Combination With Temozolomide

Columbia University

NCT00629343

COMPLETED Phase 1 24 participants

A Study of Olaratumab (LY3012207), Doxorubicin, and Ifosfamide in Participants With Advanced or Metastatic Soft Tissue Sarcoma

Eli Lilly and Company

NCT03283696

COMPLETED Phase 2 22 participants

Efficacy and Safety Study of GPX-150 to Treat Soft Tissue Sarcoma

Gem Pharmaceuticals

NCT02267083

COMPLETED Phase 2 20 participants

Bevacizumab and Radiation Therapy for Sarcomas

Massachusetts General Hospital

NCT00356031

COMPLETED Phase 1 18 participants

HSV1716 in Patients With Non-Central Nervous System (Non-CNS) Solid Tumors

Timothy Cripe

NCT00931931

Phase Distribution

PhaseTrial count
Phase 1 22
Phase 2 20
Phase 3 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Soft Tissue Sarcoma Trial Landscape

ClinicalTrials.gov lists 54 US studies indexed under Soft Tissue Sarcoma, and 20 of those are currently open to recruitment — roughly 37% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Soft Tissue Sarcoma shows 1 late-stage studies (Phase 3 and Phase 4 combined) alongside 42 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Soft Tissue Sarcoma is led by Memorial Sloan Kettering Cancer Center with 4 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 54 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Soft Tissue Sarcoma?

PlainTrial tracks 54 US clinical trials for Soft Tissue Sarcoma, of which 20 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Soft Tissue Sarcoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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