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NCT06566092 · ClinicalTrials.gov registry record · Phase 1
Study of Autologous Tumor-Infiltrating Lymphocytes in Pediatric, Adolescent, and Young Adult Participants
A Phase 1 study of Melanoma and Soft Tissue Sarcoma, sponsored by Iovance Biotherapeutics.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 40
- Enrollment target
- 5
- Study locations
NCT06566092: Recruiting Phase 1 study of Melanoma and Soft Tissue Sarcoma, sponsored by Iovance Biotherapeutics.
NCT06566092 is a Phase 1 study of Melanoma and Soft Tissue Sarcoma that is actively recruiting participants, run by Iovance Biotherapeutics. The registered enrollment target is 40 participants, below the 706-participant average among 266 other Melanoma trials with a reported enrollment target (94% lower). The trial reports 5 study locations across 4 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06566092, a Phase 1 study of Melanoma and Soft Tissue Sarcoma, is actively recruiting participants, sponsored by Iovance Biotherapeutics.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 40 participants
- Enrollment target
- 5
- Study locations
Study Summary
This study is planned to test the safety and tolerability of the TIL regimen. The study will also test how well TIL fights cancer. The study will enroll children, teenagers, and young adults with solid tumors that have returned or are not responding to treatment for whom no effective standard-of-care treatment options exist. Study details include: * The study will last up to 2 years after the TIL infusion (Day 0) for each person. * The treatment will last up to 10 days for each person. * Study visits will be every 2 weeks until Day 42, every 6 weeks until Month 6, and every 3 months until Year 2.
Primary Outcome
To evaluate the safety and tolerability of the TIL regimen that occurs from the start of TIL infusion and up to 30 days after TIL infusion per CTCAE.
Conditions Studied
Interventions
- BIOLOGICAL LN-145/LN-144
Study Locations (5)
New York
- Roswell Park Cancer Institute - Buffalo
- Memorial Sloan Kettering Cancer Center - New York
Colorado
- Children's Hospital of Colorado - Aurora
Florida
- Johns Hopkins All Children's Hospital - St. Petersburg
New Jersey
- Rutgers Cancer Institute - New Brunswick
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 40 participants |
| Start Date | 2024-03-28 |
| Est. Completion | 2028-07 |
| Phase | Phase 1 |
What NCT06566092 shows while recruiting
NCT06566092 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 40 participants, a relatively small participant target, below the 706-participant average among 266 other Melanoma trials with a reported enrollment target (94% lower).
The record links to 5 conditions, with Melanoma appearing as the primary indexed condition, and to 1 intervention - of which LN-145/LN-144 is the first listed.
NCT06566092 lists 5 locations in 4 states (New York, Colorado, Florida).
Frequently Asked Questions
What is clinical trial NCT06566092 about?
NCT06566092 is a clinical study titled "Study of Autologous Tumor-Infiltrating Lymphocytes in Pediatric, Adolescent, and Young Adult Participants". This study is planned to test the safety and tolerability of the TIL regimen. The study will also test how well TIL fights cancer. The study will enroll children, teenagers, and young adults with solid tumors that have returned or are not responding to treatment for whom no effective standard-of-car...
What is the current status of trial NCT06566092?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 40 participants. The study started on 2024-03-28. Estimated completion is 2028-07.
What conditions does trial NCT06566092 study?
This clinical trial studies the following conditions: Melanoma, Soft Tissue Sarcoma, Rhabdomyosarcoma, Ewing Sarcoma, Primary Central Nervous System Carcinoma.
What interventions are being tested in trial NCT06566092?
The interventions under investigation include: LN-145/LN-144 (BIOLOGICAL).
Who is sponsoring clinical trial NCT06566092?
This trial is sponsored by Iovance Biotherapeutics, which has 12 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06566092 being conducted?
This trial has 5 study locations across Colorado, Florida, New Jersey, New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT06566092's enrollment target sits among peer trials
40 177th of 266 higher than 85 of 266 other Melanoma trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Melanoma trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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