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COMPLETED Phase 2

Phase II Study of Brivanib (BMS-582664) to Treat Multiple Tumor Types

NCT00633789 · View on ClinicalTrials.gov ↗

Study Summary

The purpose of this study is to determine if gastric/esophageal, lung, pancreatic, bladder and sarcoma patients show benefit from brivanib treatment. Patients who clearly do, stay on treatment. Those in which it is unclear will be randomized to continue or withdraw treatment to determine whether that benefit is related to brivanib

Interventions

  • DRUG Placebo
  • DRUG brivanib

Study Locations (20)

Other

  • Local Institution — Brussels
  • Local Institution — Brussels
  • Local Institution — Brussels
  • Local Institution — Paris
  • Local Institution — Paris
  • Local Institution — Freiburg im Breisgau
  • Local Institution — Halle
  • Local Institution — Maastricht

Buenos Aires

  • Local Institution — Buenos Aires
  • Local Institution — Capital Federal
  • Local Institution — Capital Federal
  • Local Institution — Capital Federal

Illinois

  • University Of Chicago — Chicago
  • Northshore Univ. Healthsystem — Evanston

New York

  • Memorial Sloan Kettering Cancer Center — New York
  • Memorial Sloan Kettering Cancer Ctr — New York

Maryland

  • Sidney Kimmel Comprehensive Cancer Center At Johns Hopkins — Baltimore

Pennsylvania

  • University Of Pennsylvania — Philadelphia

Alberta

  • Local Institution — Edmonton

Ontario

  • Local Institution — Toronto

Trial Details

FieldValue
Enrollment Target 597 participants
Start Date 2008-06
Est. Completion 2012-12
Phase Phase 2

Sponsor

Bristol-Myers Squibb

504 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT00633789

The ClinicalTrials.gov registry entry for NCT00633789 describes a study currently listed as completed. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 597 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Bristol-Myers Squibb, which has 504 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 5 conditions, with Soft Tissue Sarcoma appearing as the primary indexed condition, and to 2 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT00633789 reports 20 study locations spanning 8 distinct geographic areas — top geographies include Other, Buenos Aires, Illinois. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT00633789 about?

NCT00633789 is a clinical study titled "Phase II Study of Brivanib (BMS-582664) to Treat Multiple Tumor Types". The purpose of this study is to determine if gastric/esophageal, lung, pancreatic, bladder and sarcoma patients show benefit from brivanib treatment. Patients who clearly do, stay on treatment. Those in which it is unclear will be randomized to continue or withdraw treatment to determine whether tha...

What is the current status of trial NCT00633789?

This trial is currently completed. It is a Phase 2 study. The enrollment target is 597 participants. The study started on 2008-06. Estimated completion is 2012-12.

What conditions does trial NCT00633789 study?

This clinical trial studies the following conditions: Soft Tissue Sarcoma, Advanced Non-small Cell Lung Cancer, Transitional Cell Carcinoma, Gastric/Esophageal Adenocarcinoma, Pancreatic Cancer Including Ampulla of Vater. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT00633789?

The interventions under investigation include: Placebo (DRUG), brivanib (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT00633789?

This trial is sponsored by Bristol-Myers Squibb, which has 504 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT00633789 being conducted?

This trial has 20 study locations across Illinois, Maryland, New York, Pennsylvania, Buenos Aires. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial