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COMPLETED Phase 1

Bevacizumab, Chemotherapy and Valproic Acid in Advanced Sarcomas

NCT01106872 · View on ClinicalTrials.gov ↗

Study Summary

The purpose of this study is to test the combination of the chemotherapy drugs Gemcitabine, bevacizumab, and docetaxel with valproic acid to treat patients with metastatic sarcoma. Valproic acid is used by people who have seizures to prevent seizures from happening; however, its use in cancer is investigational. This study will help define the proper dosing of this valproic acid. We will assess the safety of valproic acid with the combination of the above chemotherapy drugs and check for possible side effects. Valproic acid may improve the function of the chemotherapy drugs against the cancer.

Interventions

  • DRUG Bevacizumab, Gemcitabine, Docetaxel and Valproic Acid

Study Locations (1)

Iowa

  • University of Iowa Hospitals and Clinics — Iowa City

Trial Details

FieldValue
Enrollment Target 47 participants
Start Date 2010-09
Est. Completion 2017-08-22
Phase Phase 1

Sponsor

Mohammed M Milhem

1 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT01106872

The ClinicalTrials.gov registry entry for NCT01106872 describes a study currently listed as completed. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 47 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Mohammed M Milhem, which has 1 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 5 conditions, with Sarcoma appearing as the primary indexed condition, and to 1 intervention — of which Bevacizumab, Gemcitabine, Docetaxel and Valproic Acid is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT01106872 reports 1 study location spanning 1 distinct geographic area — top geographies include Iowa. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT01106872 about?

NCT01106872 is a clinical study titled "Bevacizumab, Chemotherapy and Valproic Acid in Advanced Sarcomas". The purpose of this study is to test the combination of the chemotherapy drugs Gemcitabine, bevacizumab, and docetaxel with valproic acid to treat patients with metastatic sarcoma. Valproic acid is used by people who have seizures to prevent seizures from happening; however, its use in cancer is inv...

What is the current status of trial NCT01106872?

This trial is currently completed. It is a Phase 1 study. The enrollment target is 47 participants. The study started on 2010-09. Estimated completion is 2017-08-22.

What conditions does trial NCT01106872 study?

This clinical trial studies the following conditions: Sarcoma, Soft Tissue Sarcoma, Metastatic Sarcoma, Locally Advanced Sarcoma, Unresectable Sarcoma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT01106872?

The interventions under investigation include: Bevacizumab, Gemcitabine, Docetaxel and Valproic Acid (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT01106872?

This trial is sponsored by Mohammed M Milhem, which has 1 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT01106872 being conducted?

This trial has 1 study location across Iowa. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial