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2026 data Public-data reference. official source

Sleep Disturbance

Open-data reference.

57 US clinical trials · 32 currently recruiting

Active & Recent Trials

RECRUITING NA 456 participants

Enhancing Sleep Quality for Nursing Home Residents With Dementia - R33 Phase

University of Alabama, Tuscaloo

NCT05820919

RECRUITING NA 342 participants

Improving Maternal Sleep and Mental Health

University of Colorado, Colorado Springs

NCT06544941

RECRUITING NA 317 participants

Home Apnea Testing in CHildren Trial

Children's Hospital of Philadelphia

NCT05382754

RECRUITING NA 276 participants

Wellness App for Sleep Disturbance in Hematological Cancer Patients

The University of Texas Health Science Center at San Antonio

NCT05294991

RECRUITING NA 240 participants

UCLA REST Study (REsearch on Sleep Techniques)

University of California, Los Angeles

NCT05576090

RECRUITING 200 participants

Medications for Opioid Use Disorder Photosensitive Retinal Ganglion Cell Function, Sleep, and Circadian Rhythms: Implications for Treatment

University of Alabama at Birmingham

NCT06104280

RECRUITING Phase 3 160 participants

REmotely-delivered Supportive Programs for Improving Surgical Pain and disTrEss

Wake Forest University Health Sciences

NCT05625360

RECRUITING NA 160 participants

RCT of a Weighted Blanket to Reduce Pain in Veterans With Chronic Pain

VA Office of Research and Development

NCT05963607

RECRUITING NA 150 participants

Sleep Disturbance and Emotion Regulation Brain Dysfunction as Mechanisms of Neuropsychiatric Symptoms in Alzheimer's Dementia

Stanford University

NCT04100057

RECRUITING NA 120 participants

Personalized Approach To Habits - Sleep

KDH Research & Communication

NCT07029919

RECRUITING NA 115 participants

SPARK Healthy Sleep

Indiana University

NCT07119268

RECRUITING 100 participants

Sleep and Central Auditory Processing Disorder in Autism Spectrum Disorder

Loma Linda University

NCT06059352

RECRUITING NA 100 participants

Sleep Promotion Program Primary Care

University of Pittsburgh

NCT06240325

RECRUITING Phase 3 100 participants

Evaluating the Effects of Tasimelteon in Individuals With Autism Spectrum Disorder (ASD) and Sleep Disturbances

Vanda Pharmaceuticals

NCT05361707

RECRUITING Phase 2 100 participants

Targeting Cognition in Early Alzheimer's Disease by Improving Sleep With Trazodone

Johns Hopkins University

NCT05282550

RECRUITING NA 100 participants

A Multi-Modal Combination Intervention to Promote Cognitive Function in Older Intensive Care Unit Survivors

University of Washington

NCT06411561

RECRUITING NA 90 participants

A Study to Evaluate the Effects of a Supplement on the Side Effects Associated With Stimulant Medications

Outliers

NCT07380412

RECRUITING NA 90 participants

Transdiagnostic Sleep and Circadian Intervention + Bright Light in Adolescents With Elevated Depression (TranS-C+BL)

University of Pittsburgh

NCT06963463

RECRUITING NA 80 participants

Sleep Enhancement for Older Adults Living With Memory Loss And Their Care Partners

Emory University

NCT06250725

RECRUITING Phase 2 80 participants

Nuestro Sueno: Cultural Adaptation of a Couples Intervention to Improve PAP Adherence and Sleep Health Among Latino Couples With Implications for Alzheimer's Disease Risk

University of Utah

NCT06649929

RECRUITING NA 70 participants

The Iowa ACEs and Sleep Cohort and Manipulating Sleep in Young Adults With ACEs Studies

Nathaniel Jenkins

NCT06454344

RECRUITING NA 55 participants

The Dream Team: Testing Implementation of a Sleep Intervention for Perinatal Women Delivered by Direct Care Workers

Rhode Island Hospital

NCT06737055

RECRUITING NA 50 participants

Optimizing Attention and Sleep Intervention Study

University of Pittsburgh

NCT05683756

RECRUITING Phase 4 40 participants

Using Dupilumab to Improve Circadian Function, Sleep and Pruritus in Children With Moderate/Severe Atopic Dermatitis

Northwestern University

NCT05042258

RECRUITING NA 40 participants

Art Therapy and Emotional Well Being in Military Populations With Posttraumatic Stress Symptoms

Walter Reed National Military Medical Center

NCT05414708

RECRUITING NA 34 participants

VR-PMR for Post-Burn Symptoms

Johns Hopkins University

NCT07317271

RECRUITING NA 30 participants

PICU-related Sleep and Circadian Dysregulation Pilot Study

State University of New York at Buffalo

NCT06505447

RECRUITING NA 23 participants

Adjunctive Bright Light Therapy for Opioid Use Disorder

Arizona State University

NCT05459922

RECRUITING NA 20 participants

Mindfulness-Based Intervention for Pain and Sleep in Adolescents and Young Adults With Sickle Cell Disease

University of Illinois at Chicago

NCT07402811

RECRUITING NA 20 participants

The Acute T-Rex (Timing of Resistance Exercise) Study

University of Utah

NCT06366399

RECRUITING NA 10 participants

Developing Restful Environments and Management Strategies for Pediatric Stem Cell Transplant Patients

Dana-Farber Cancer Institute

NCT06468618

RECRUITING NA 10 participants

The Power Down Pilot Study: A Novel Bedtime Manipulation Protocol

University of Pittsburgh

NCT06386029

ACTIVE NOT RECRUITING Phase 2 470 participants

RECOVER-SLEEP: Platform Protocol, Appendix_B (CPSD)

Duke University

NCT06404112

ACTIVE NOT RECRUITING NA 180 participants

Auricular Acupuncture for Sleep Disturbances

Paul Crawford

NCT04956341

ACTIVE NOT RECRUITING NA 95 participants

Improving Sleep in Gynecologic Cancer Survivors

University of Arizona

NCT05044975

ACTIVE NOT RECRUITING NA 50 participants

Racial Differences in Circadian and Sleep Mechanisms for Nicotine Dependence, Craving, and Withdrawal

University of Alabama at Birmingham

NCT03968900

ACTIVE NOT RECRUITING NA 50 participants

Sweet Scents to Sweet Dreams

Duquesne University

NCT06247696

ACTIVE NOT RECRUITING NA 30 participants

Settling Down for Sleep in ADHD: The Impact of Sensory and Arousal Systems on Sleep in ADHD

University of Pittsburgh

NCT06406309

ACTIVE NOT RECRUITING NA 28 participants

Dry Needling and Therapeutic Exercise on Sleep in Individuals With Chronic Neck Pain and Sleep Disturbance

Mayo Clinic

NCT06275074

COMPLETED NA 2,118 participants

Providing Mental Health Precision Treatment

University of Michigan

NCT04342494

COMPLETED Phase 2 830 participants

RECOVER-SLEEP: Platform Protocol

Duke University

NCT06404086

COMPLETED NA 500 participants

Radicle Revive 24: A Study of Health and Wellness Products on Menopausal Health and Related Health Outcomes

Radicle Science

NCT06749288

COMPLETED NA 388 participants

Calm Sleep Coaching

Arizona State University

NCT04566822

COMPLETED NA 367 participants

Cognitive Behavioral Therapy for Arthritis Pain and Insomnia in Older Adults

University of Washington

NCT01142349

COMPLETED NA 188 participants

A Brief Patient-Controlled Intervention for a Symptom Cluster in Advanced Cancer

University of Wisconsin, Madison

NCT01954420

COMPLETED NA 128 participants

A Study of a Sleep Supplement to Improve Sleep in Women Going Through Menopause

Bonafide Health

NCT07375095

COMPLETED NA 114 participants

Sleep Assessment: The Benefits of Identifying Sleep Disturbance Using a Sleep Questionnaire

University of Texas at Austin

NCT06074224

COMPLETED NA 108 participants

Sleep Hygiene Intervention on Undergraduate Students' Sleep and Stress

Wayne State University

NCT05933746

COMPLETED NA 91 participants

Telehealth Delivery of Treatment for Sleep Disturbances in Young Children With Autism Spectrum Disorder

The Cleveland Clinic

NCT03668873

COMPLETED NA 90 participants

Impact of Bed Provision and Sleep Education

Saint Joseph's University, Philadelphia

NCT04536766

COMPLETED NA 90 participants

Treatment for Sleep Disturbance in Orthopaedic Trauma Patients

Stanford University

NCT03779243

COMPLETED Phase 2 75 participants

Clinical Benefits of a Novel Sleep-focused Mind-body Program on Gulf War Illness (GWI) Symptoms

University of Utah

NCT01543997

COMPLETED NA 68 participants

Stepped-Care Telehealth for Distress in Cancer Survivors

Wake Forest University Health Sciences

NCT03060096

COMPLETED NA 52 participants

Wearable Neural Interfacing System for REM Sleep Restoration and Enhancement

University of Texas at Austin

NCT07190287

COMPLETED NA 40 participants

A SMART Design to Improve Sleep Disturbance in Adolescents With Neurodevelopmental Disorders

University of Nebraska

NCT03730194

COMPLETED NA 16 participants

Sleep Promotion Program Primary Care (SPP PC) Open Trial

University of Pittsburgh

NCT06239792

COMPLETED NA 15 participants

Implementing Behavioral Sleep Intervention in Urban Primary Care

Children's Hospital of Philadelphia

NCT04046341

Phase Distribution

PhaseTrial count
Phase 2 5
Phase 3 2
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Sleep Disturbance Trial Landscape

ClinicalTrials.gov lists 57 US studies indexed under Sleep Disturbance, and 32 of those are currently open to recruitment — roughly 56% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Sleep Disturbance shows 3 late-stage studies (Phase 3 and Phase 4 combined) alongside 5 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Sleep Disturbance is led by University of Pittsburgh with 6 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 57 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Sleep Disturbance?

PlainTrial tracks 57 US clinical trials for Sleep Disturbance, of which 32 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Sleep Disturbance?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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