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Trauma clinical trials
Every US clinical trial registered for Trauma — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.
57 US clinical trials · 25 currently recruiting
The research picture
Trauma has 57 registered US clinical trials, 25 of them open to new participants right now — about 44% of the total.
- 25
- recruiting participants now
- 44%
- of trials open to enrollment
- 5
- in Phase 3–4 (later-stage)
- 5
- top sponsor: Massachusetts General Hospital
Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.
Active & Recent Trials
RCT: Early Feeding After PEG Placement
Carilion Clinic
NCT04110613
CAlcium and VAsopressin Following Injury Early Resuscitation (CAVALIER) Trial
Jason Sperry
NCT05958342
Evaluation of the Parenting in the Moment Online Program for Forcibly Displaced Families
Arizona State University
NCT06548126
Effectiveness, Implementation, and Cost of Cognitive Processing Therapy in Prisons
University of Arkansas
NCT06923423
Lovenox 30 mg Twice Daily (BID) Versus 40 mg Once Daily (QD)
Oregon Health and Science University
NCT02342444
Women Focused Encounters for Resilience Independence Strength and Eudaimonia
University of California, San Diego
NCT06216600
The Role of Brain-Bone Marrow-Gut Interaction Following Major Trauma
University of Florida
NCT06606119
PRESERVE & CONNECT: Impact Study of the BPC
University of Vermont
NCT06160050
Testing FIRST in Youth Outpatient Psychotherapy
Harvard University
NCT04725721
Multiphase Optimization Strategy (MOST) for Treating Pediatric Post-traumatic Stress Disorder (PTSD)
University of Rochester
NCT06956781
Respiratory Training in the Treatment of Transdiagnostic Pathological Anxiety
University of Texas at Austin
NCT05427708
A Clinical Trial of Interventions to Support Family Surrogates of Critically Ill Patients
Weill Medical College of Cornell University
NCT05587517
Study of Cannabidiol and Neuroimaging on Stress
Icahn School of Medicine at Mount Sinai
NCT07278505
Magnesium Infusion for Pain Management in Critically Ill Trauma Patients
University of California, Davis
NCT04166877
MultiStem® for Treatment of Trauma Induced Multiple Organ Failure/Systemic Inflammatory Response Syndrome
Healios K.K.
NCT04533464
Effects of Games on Memory Reconsolidation and Trauma Symptoms
University of Texas at Austin
NCT06129435
Onyx™ Liquid Embolic IDE Clinical Study
Medtronic Endovascular
NCT06742801
IlluminOss Photodynamic Bone Stabilization System for the Treatment of Impending and Actual Pelvis Fractures
Massachusetts General Hospital
NCT04842266
Nonopioid Pain Control Regimen After Open Reduction and Internal Fixation of Traumatic Fractures
Henry Ford Health System
NCT06113211
REVIVE: Reducing Exsanguination Via In-Vivo Expandable Foam
Arsenal Medical
NCT02880163
OCT in Open Fracture and Infected Fracture
Dartmouth-Hitchcock Medical Center
NCT05785182
PMCF Study to Evaluate the VERTICALE® Cervical System in Spine Surgery According to Its Intended Use.
Silony Medical
NCT05489822
An Imaging Framework for Clinically Testing New Treatments to Prevent Post-traumatic OA
J L Marsh
NCT03809520
Mg OSTEOCRETE Post-Treatment Outcomes
Santiago Lozano-Calderon
NCT06720142
Comparative Outcomes of PCC and Recombinant Activated Factor VIIa in Trauma-Associated Massive Transfusion
Zeliha Alicikus
NCT07290634
Illuminating Neuropsychological Dysfunction and Systemic Inflammatory Mechanisms Gleaned After Hospitalization in Trauma-ICU Study
Vanderbilt University Medical Center
NCT03098459
Humacyte Human Acellular Vessel (HAV) in Patients With Vascular Trauma
Humacyte
NCT03005418
Analysis of Pedicle Screw Accuracy to Plan Using Medtronic Mazor Robotic System
Ohio State University
NCT05884593
Teenage Driving Safety Study: An Emergency Medicine-Trauma Collaborative Study
Lehigh Valley Hospital
NCT01402856
Use of Hextend in Trauma
University of Miami
NCT00983281
Maintaining Optimal Trauma Outcomes: Resilience in the Midst of a Ransomware Attack
State University of New York at Buffalo
NCT04881279
Inflammation and the Host Response to Injury (Trauma)
Massachusetts General Hospital
NCT00257231
Supplemental Enteral Protein in Critical Illness
University of Washington
NCT03170401
Quantra QStat in Trauma and Liver Transplant
HemoSonics
NCT04312958
Disseminating Child Abuse Clinical Decision Support to Improve Detection, Evaluation and Reporting
University of Pittsburgh
NCT03840798
Inflammation and the Host Response to Injury (Burns)
Massachusetts General Hospital
NCT00257244
Frozen Red Blood Cell Transfusions in Trauma Patients
Oregon Health and Science University
NCT01038557
Key Dimensions of PTSD and ED
University of California, Los Angeles
NCT03778307
Use of a Non-ICU Specialty Ward For Immediate Post-operative Management of Head and Neck Free Flaps
University of California, Davis
NCT03340038
Experiential Training in Eliciting Disclosure & Emotions for Mental Health Trainees
Mark A. Lumley
NCT04511754
Using Neuroimaging to Understand Children's Mental Health and Treatment Outcomes
Harvard University
NCT03112265
Treatment for Sleep Disturbance in Orthopaedic Trauma Patients
Stanford University
NCT03779243
CT C-spine Audit and Feedback
University of Massachusetts, Worcester
NCT05711134
Incidence/Magnitude-Haemorrhagic Progression-Cerebral Contusions and Identification (ID) of Safety Issues After Traumatic Brain Injury
Novo Nordisk A/S
NCT00124293
BVA-200 vs BVA-100 Validation Study
Daxor Corporation
NCT06227819
Longitudinal Gene Expression Profiling in Adults After Traumatic Injury
Stanford University
NCT02656459
Brief Intervention for Chronic Pain and History of Stressful Experiences
Brigham and Women's Hospital
NCT06983327
A Trauma-Informed Approach for Positive Youth Development for Montana Students
Montana State University
NCT04664855
Personalized Nutrition Delivery to Improve Resilience in Older Adult Trauma Patients
Duke University
NCT05544162
Trauma Informed Intervention to Support Engagement in HIV Care Among MSM (THRIVE+)
Massachusetts General Hospital
NCT05822206
Rotational Thromboelastometry Activated Transfusion In Trauma Trial
University of Texas Southwestern Medical Center
NCT03765866
Developing a Trauma-focused Intervention for Older Adults Living With HIV
University of South Carolina
NCT05287230
Efficacy of Lidocaine Patch in Acute Musculoskeletal Pain in the Emergency Department
East Carolina University
NCT03571737
QStat in Trauma and Obstetric Hemorrhage
HemoSonics
NCT04385953
Burn Outcomes in Young Adult Burn Survivors
Massachusetts General Hospital
NCT01254357
Cognitive Behavioral Therapy for Insomnia vs. Exposure, Relaxation, and Rescripting Therapy
University of Tul
NCT03831412
Plasma Cytochrome c as Biomarker of Traumatic Injury and Predictor of Outcome
Wake Forest University Health Sciences
NCT02440373
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 1 |
| Phase 2 | 4 |
| Phase 3 | 2 |
| Phase 4 | 3 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Trauma Trial Landscape
ClinicalTrials.gov lists 57 US studies indexed under Trauma, and 25 of those are currently open to recruitment — roughly 44% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Trauma shows 5 late-stage studies (Phase 3 and Phase 4 combined) alongside 5 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Trauma is led by Massachusetts General Hospital with 5 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 57 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Trauma?
PlainTrial tracks 57 US clinical trials for Trauma, of which 25 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Trauma?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.