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NCT00550043 · ClinicalTrials.gov registry record · Phase 2

A Study Exploring the Safety, Tolerability and Efficacy of a 4 Week Course of INCB018424 in Subjects With Active Rheumatoid Arthritis

A Phase 2 study of Rheumatoid Arthritis, sponsored by Incyte Corporation.

Completed
Registry status
Phase 2
Development phase
50
Enrollment target
15
Study locations

NCT00550043: Completed Phase 2 study of Rheumatoid Arthritis, sponsored by Incyte Corporation.

NCT00550043 is a Phase 2 study of Rheumatoid Arthritis that has completed, run by Incyte Corporation. The registered enrollment target is 50 participants, below the 4,690-participant average among 197 other Rheumatoid Arthritis trials with a reported enrollment target (99% lower). The trial reports 15 study locations across 9 states. According to ClinicalTrials.gov, the official US trial registry.

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The verdict

NCT00550043, a Phase 2 study of Rheumatoid Arthritis, has completed, sponsored by Incyte Corporation.

COMPLETED
Registry status
Phase 2
Development phase
50 participants
Enrollment target
15
Study locations

Study Summary

The purpose of this study is to understand the safety and tolerability of INCB018424 in patients with rheumatoid arthritis

Primary Outcome

The ACR 20 is defined as ≥ 20% improvement in tender joint count plus ≥ 20% improvement in swollen joint count plus ≥ 20% improvement in 3 of the following 5 criteria: subject's assessment of pain, Subject's global assessment of disease activity (PGA), Physician's global assessment of disease activity (PHGA), subject's self-assessed disability Health Assessment Questionnaire (HAQ), and Erythrocyte sedimentation rate (ESR) or C-reactive protein (CRP), whichever shows the greatest change.

Conditions Studied

Rheumatoid Arthritis

Interventions

  • DRUG Placebo
  • DRUG INCB018424

Study Locations (15)

Ohio

  • - Mayfield Village,
  • - Middleburg Heights
  • - Perrysburg

Other

  • - Elblag
  • - Gmina Końskie
  • - Warsaw

Florida

  • - Gainesville
  • - Palm Harbor

Tennessee

  • - Hixson
  • - Memphis

Alabama

  • - Huntsville

California

  • - Upland

Montana

  • - Kalispell

North Carolina

  • - Hickory

Trial Details

FieldValue
Enrollment Target 50 participants
Start Date 2007-10
Est. Completion 2008-09
Phase Phase 2
Incyte Corporation

239 total trials

What the finished NCT00550043 record still lists

NCT00550043 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 50 participants, a relatively small participant target, below the 4,690-participant average among 197 other Rheumatoid Arthritis trials with a reported enrollment target (99% lower).

The record links to 1 condition, with Rheumatoid Arthritis appearing as the primary indexed condition, and to 2 interventions - of which Placebo is the first listed.

NCT00550043 lists 15 locations in 9 states (Ohio, Other, Florida).

Frequently Asked Questions

What is clinical trial NCT00550043 about?

NCT00550043 is a clinical study titled "A Study Exploring the Safety, Tolerability and Efficacy of a 4 Week Course of INCB018424 in Subjects With Active Rheumatoid Arthritis". The purpose of this study is to understand the safety and tolerability of INCB018424 in patients with rheumatoid arthritis

What is the current status of trial NCT00550043?

This trial is currently completed. It is a Phase 2 study. The enrollment target is 50 participants. The study started on 2007-10. Estimated completion is 2008-09.

What conditions does trial NCT00550043 study?

This clinical trial studies the following conditions: Rheumatoid Arthritis.

What interventions are being tested in trial NCT00550043?

The interventions under investigation include: Placebo (DRUG), INCB018424 (DRUG).

Who is sponsoring clinical trial NCT00550043?

This trial is sponsored by Incyte Corporation, which has 239 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT00550043 being conducted?

This trial has 15 study locations across Alabama, California, Florida, Montana, North Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Learn More About Clinical Trials

Similar trials for Rheumatoid Arthritis

Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.

Where NCT00550043's enrollment target sits among peer trials

50 140th of 197 higher than 56 of 197 other Rheumatoid Arthritis trials

participants (enrollment target), bucketed by value

Each bar is a band; taller bars hold more other Rheumatoid Arthritis trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.

Source ClinicalTrials.gov registry export · 2026-08-08

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Related registry views

Source: ClinicalTrials.gov NCT00550043, the US trial registry maintained by the National Library of Medicine. NCT00550043 (small enrollment · multi site footprint · completed) retrieved and formatted by PlainTrial, see methodology.