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Respiratory Failure
Open-data reference.
41 US clinical trials · 13 currently recruiting
Active & Recent Trials
Optimizing Care in Critically Ill at UCHealth by Liberalizing the Target O2 in Mechanically-ventilated ICU Patients
University of Colorado, Denver
NCT06501118
End-Tidal Oxygen for Intubation in the Emergency Department
Sydney Local Health District
NCT06578468
Precision Ventilation vs Standard Care for Acute Respiratory Distress Syndrome
Beth Israel Deaconess Medical Center
NCT06066502
Hospital Airway Resuscitation Trial
Montefiore Medical Center
NCT05520762
Respiratory Knowledge Portal Computer and Phone Application to Improve Quality of Mechanical Ventilation by Reducing the Number of Ventilator Associated Events, Injury Created by the Ventilator and Unsafe Setting of Alarms.
The University of Texas Medical Branch, Galveston
NCT06737432
Analgesia-First Sedation in Trauma Patients
MemorialCare Health System
NCT05751863
Transpulmonary Pressure Guided Mechanical Ventilation Weaning in Obesity
University of Mississippi Medical Center
NCT05530434
Bio-Banking of Specimens for Advanced Lung Disease and Lung Transplant Research
Baylor Research Institute
NCT04664192
The Family Perspectives Project Pilot Trial
Matthew Modes
NCT06039501
Improving Psychological Outcomes for Acute Respiratory Failure Survivors Using a Self-Management Intervention
Johns Hopkins University
NCT06341972
A Trial Comparing High-Flow Nasal Cannula Versus Noninvasive Ventilation on Reintubation and Post-Extubation Respiratory Failure in High-Risk Patients With Systolic Heart Failure
Yale University
NCT06671015
Low and High Flow Suctioning in Intubated Infants
Columbia University
NCT06443970
Supraglottic Airway for Resuscitation in Preemies
University of Pennsylvania
NCT07419438
A Rapid Diagnostic of Risk in Hospitalized Patients Using Machine Learning
AgileMD
NCT05893420
Long Term Outcomes of Patients With COVID-19
University of Chicago
NCT04360538
CYCLE: A Randomized Clinical Trial of Early In-bed Cycling for Mechanically Ventilated Patients
McMaster University
NCT03471247
Feasibility of the Comfort Measures Only Time Out (CMOT)
Beth Israel Deaconess Medical Center
NCT05861323
Veno-venous Extracorporeal Membrane Oxygenation (VV-ECMO) Heparin Study
Baylor Research Institute
NCT04496362
The Effects of Vertical Position on Gas Exchange in Patients With Respiratory Failure
University of Chicago
NCT01705119
Effect of Volume and Type of Fluid on Postoperative Incidence of Respiratory Complications and Outcome (CRC-Study)
Massachusetts General Hospital
NCT02105298
Prevention of Severe Acute Respiratory Failure in Patients With PROOFCheck
Albert Einstein College of Medicine
NCT02488174
Heart And Lung Failure - Pediatric INsulin Titration Trial
Boston Children's Hospital
NCT01565941
Oral Suction Intervention to Reduce Aspiration and Ventilator Events: NO-ASPIRATE
University of Central Florida
NCT02284178
Preventing Hypoxemia With Manual Ventilation During Endotracheal Intubation (PreVent) Trial
Vanderbilt University Medical Center
NCT03026322
Proning Early in Awake COVID-19 Hypoxic Respiratory Failure (PREACHR) Study
New York Hospital Queens
NCT05130541
FiO2 Closed Loop Control Ventilation
Zoll Medical Corporation
NCT02810080
Ganciclovir/Valganciclovir for Prevention of CMV Reactivation in Acute Injury of the Lung and Respiratory Failure
Fred Hutchinson Cancer Center
NCT01335932
Inspiratory Muscle Training in Ventilator Dependent Patients
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NCT00419458
Pragmatic Investigation of Volume Targeted Ventilation-1
Wake Forest University Health Sciences
NCT03909854
Prognostic Value of Point of Care Cardiac and Lung Ultrasound in COVID-19
University of Pennsylvania
NCT04379544
Safety and Efficacy of Endotracheal Intubation Using Glidescope Video-Laryngoscope
Beth Israel Medical Center
NCT01683526
CYCLE Pilot Randomized Trial
McMaster University
NCT02377830
Cuff Leak Test and Airway Obstruction in Mechanically Ventilated ICU Patients
St. Joseph's Healthcare Hamilton
NCT05456542
Use of Lung Ultrasound to Diagnose the Etiology of Respiratory Failure in a PICU.
University of Wisconsin, Madison
NCT03744169
Vitamin D in Ventilated ICU Patients
Emory University
NCT01372995
The Use of the GlideScope Ranger in Pediatric Critical Care Transport
Akron Children's Hospital
NCT01054183
CTSI-iPad for Vented Patient Communication
Medical College of Wisconsin
NCT03163823
Nebulized Hypertonic Saline for Mechanically Ventilated Children
University Hospitals Cleveland Medical Center
NCT01945944
Assessment of Breathing Using an Under-bed Weighing Scale
Beth Israel Deaconess Medical Center
NCT04736212
Inhaled Nitric Oxide by Oxygen Hood in Neonates
University of Alabama at Birmingham
NCT00732537
A Randomized, Controlled Trial of Inspiratory Muscle Training (IMT)in the ICU and CCU
Wake Forest University Health Sciences
NCT02003053
Phase Distribution
| Phase | Trial count |
|---|---|
| Early Phase 1 | 2 |
| Phase 2 | 3 |
| Phase 3 | 3 |
| Phase 4 | 2 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Respiratory Failure Trial Landscape
ClinicalTrials.gov lists 41 US studies indexed under Respiratory Failure, and 13 of those are currently open to recruitment — roughly 32% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Respiratory Failure shows 5 late-stage studies (Phase 3 and Phase 4 combined) alongside 5 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Respiratory Failure is led by Beth Israel Deaconess Medical Center with 3 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 41 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Respiratory Failure?
PlainTrial tracks 41 US clinical trials for Respiratory Failure, of which 13 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Respiratory Failure?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.