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COMPLETED NA

Preventing Hypoxemia With Manual Ventilation During Endotracheal Intubation (PreVent) Trial

NCT03026322 · View on ClinicalTrials.gov ↗

Study Summary

Complications are common during endotracheal intubation of critically ill adults. Manual ventilation between induction and intubation ("bag-valve-mask" ventilation) has been proposed as a means of preventing hypoxemia, the most common complication of intubation outside the operating room. Safety and efficacy data, however, are lacking. PreVent is a randomized trial comparing manual ventilation between induction and laryngoscopy to no manual ventilation between induction an laryngoscopy during endotracheal intubation of critically ill adults. The primary efficacy endpoint will be the lowest arterial oxygen saturation. The primary safety endpoints will be the lowest oxygen saturation, highest fraction of inspired oxygen, and highest positive end-expiratory pressure in the 24 hours after the procedure.

Interventions

  • OTHER Manual Ventilation
  • OTHER No Manual Ventilation

Study Locations (5)

Louisiana

  • Louisiana State University School of Medicine — New Orleans
  • Ochsner Health System — New Orleans

Alabama

  • The University of Alabama at Birmingham — Birmingham

Tennessee

  • Vanderbilt University Medical Center — Nashville

Washington

  • Harborview Medical Center, University of Washington — Seattle

Trial Details

FieldValue
Enrollment Target 401 participants
Start Date 2017-03-15
Est. Completion 2018-07-06
Phase NA

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT03026322

The ClinicalTrials.gov registry entry for NCT03026322 describes a study currently listed as completed. It is categorized as NA, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 401 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Vanderbilt University Medical Center, which has 695 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 3 conditions, with Respiratory Failure appearing as the primary indexed condition, and to 2 interventions — of which Manual Ventilation is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT03026322 reports 5 study locations spanning 4 distinct geographic areas — top geographies include Louisiana, Alabama, Tennessee. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT03026322 about?

NCT03026322 is a clinical study titled "Preventing Hypoxemia With Manual Ventilation During Endotracheal Intubation (PreVent) Trial". Complications are common during endotracheal intubation of critically ill adults. Manual ventilation between induction and intubation ("bag-valve-mask" ventilation) has been proposed as a means of preventing hypoxemia, the most common complication of intubation outside the operating room. Safety and...

What is the current status of trial NCT03026322?

This trial is currently completed. It is a NA study. The enrollment target is 401 participants. The study started on 2017-03-15. Estimated completion is 2018-07-06.

What conditions does trial NCT03026322 study?

This clinical trial studies the following conditions: Respiratory Failure, Endotracheal Intubation, Respiratory Failure With Hypoxia. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT03026322?

The interventions under investigation include: Manual Ventilation (OTHER), No Manual Ventilation (OTHER). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT03026322?

This trial is sponsored by Vanderbilt University Medical Center, which has 695 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT03026322 being conducted?

This trial has 5 study locations across Alabama, Louisiana, Tennessee, Washington. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial