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NCT06671015 · ClinicalTrials.gov registry record · NA
A Trial Comparing High-Flow Nasal Cannula Versus Noninvasive Ventilation on Reintubation and Post-Extubation Respiratory Failure in High-Risk Patients With Systolic Heart Failure
A NA study of Respiratory Failure and Systolic Heart Failure, sponsored by Yale University.
- Recruiting
- Registry status
- NA
- Development phase
- 50
- Enrollment target
- 1
- Study location
NCT06671015: Recruiting NA study of Respiratory Failure and Systolic Heart Failure, sponsored by Yale University.
NCT06671015 is a NA study of Respiratory Failure and Systolic Heart Failure that is actively recruiting participants, run by Yale University. The registered enrollment target is 50 participants, below the 4,523-participant average among 40 other Respiratory Failure trials with a reported enrollment target (99% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06671015, a NA study of Respiratory Failure and Systolic Heart Failure, is actively recruiting participants, sponsored by Yale University.
- RECRUITING
- Registry status
- NA
- Development phase
- 50 participants
- Enrollment target
- 1
- Study location
Study Summary
This prospective, open-label randomized controlled pilot trial will enroll participants at the Yale New Haven Hospital. Patients with systolic heart failure, defined as an ejection fraction ≤40%, who require invasive mechanical ventilation (IMV) and are admitted to either the cardiac intensive care unit (CICU) or medical ICU (MICU) will be included. Subjects meeting eligibility criteria will be randomized 1:1 to one of the two treatment groups: * Intervention: Extubation to high-flow nasal cannula (HFNC) * Control: Extubation to non-invasive ventilation (NIV)
Primary Outcome
Number of participants with reintubation or respiratory failure within 72 hours post-extubation
Conditions Studied
Interventions
- DEVICE Airvo 3
Study Locations (1)
Connecticut
- Yale New Haven Hospital (CICU or MICU) - New Haven
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 50 participants |
| Start Date | 2025-10-04 |
| Est. Completion | 2026-02 |
| Phase | NA |
What NCT06671015 shows while recruiting
NCT06671015 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 50 participants, a relatively small participant target, below the 4,523-participant average among 40 other Respiratory Failure trials with a reported enrollment target (99% lower).
The record links to 2 conditions, with Respiratory Failure appearing as the primary indexed condition, and to 1 intervention - of which Airvo 3 is the first listed.
NCT06671015 reports a single indexed study location in Connecticut.
Frequently Asked Questions
What is clinical trial NCT06671015 about?
NCT06671015 is a clinical study titled "A Trial Comparing High-Flow Nasal Cannula Versus Noninvasive Ventilation on Reintubation and Post-Extubation Respiratory Failure in High-Risk Patients With Systolic Heart Failure". This prospective, open-label randomized controlled pilot trial will enroll participants at the Yale New Haven Hospital. Patients with systolic heart failure, defined as an ejection fraction ≤40%, who require invasive mechanical ventilation (IMV) and are admitted to either the cardiac intensive care ...
What is the current status of trial NCT06671015?
This trial is currently recruiting. It is a NA study. The enrollment target is 50 participants. The study started on 2025-10-04. Estimated completion is 2026-02.
What conditions does trial NCT06671015 study?
This clinical trial studies the following conditions: Respiratory Failure, Systolic Heart Failure.
What interventions are being tested in trial NCT06671015?
The interventions under investigation include: Airvo 3 (DEVICE).
Who is sponsoring clinical trial NCT06671015?
This trial is sponsored by Yale University, which has 1,492 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06671015 being conducted?
This trial has 1 study location across Connecticut. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06671015's enrollment target sits among peer trials
50 31st of 40 higher than 10 of 40 other Respiratory Failure trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Respiratory Failure trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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