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NCT05456542 · ClinicalTrials.gov registry record · Phase 3
Cuff Leak Test and Airway Obstruction in Mechanically Ventilated ICU Patients
A Phase 3 study of Respiratory Failure, sponsored by St. Joseph's Healthcare Hamilton.
- Completed
- Registry status
- Phase 3
- Development phase
- 100
- Enrollment target
- 5
- Study locations
NCT05456542: Completed Phase 3 study of Respiratory Failure, sponsored by St. Joseph's Healthcare Hamilton.
NCT05456542 is a Phase 3 study of Respiratory Failure that has completed, run by St. Joseph's Healthcare Hamilton. The registered enrollment target is 100 participants, below the 4,521-participant average among 40 other Respiratory Failure trials with a reported enrollment target (98% lower). The trial reports 5 study locations across 3 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05456542, a Phase 3 study of Respiratory Failure, has completed, sponsored by St. Joseph's Healthcare Hamilton.
- COMPLETED
- Registry status
- Phase 3
- Development phase
- 100 participants
- Enrollment target
- 5
- Study locations
Study Summary
The COSMIC trial will be a multicentred, national, parallel-group, pragmatic vanguard pilot trial.
Primary Outcome
Define a successful adherence rate as ≥75%. We will calculate the adherence as the proportion of patients that are assigned to the intervention arm following the appropriate treatment algorithm and those assigned to the control arm being extubated without a cuff leak test. As this pilot trial is ongoing, we will review adherence monthly and investigate the reasons for compliance failure. We will investigate all reasons for failure to follow the treatment algorithm in the intervention arm, failur
Conditions Studied
Interventions
- DRUG Dexamethasone 4mg
- DIAGNOSTIC_TEST Cuff Leak Test
Study Locations (5)
Ontario
- Brantford General Hospital - Brantford
- St. Joseph's Healthcare Hamilton - Hamilton
- Niagara Health System - Saint Catherines
Texas
- The University of Texas Health Science Center at Houston - Houston
Other
- Al-Amiri Hospital - Kuwait City
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 100 participants |
| Start Date | 2023-04-05 |
| Est. Completion | 2025-01-06 |
| Phase | Phase 3 |
What the finished NCT05456542 record still lists
NCT05456542 is an interventional study that assigns participants to a tested intervention. The registered 100 participants enrollment target is mid-sized for trials with a published cap, below the 4,521-participant average among 40 other Respiratory Failure trials with a reported enrollment target (98% lower).
The record links to 1 condition, with Respiratory Failure appearing as the primary indexed condition, and to 2 interventions - of which Dexamethasone 4mg is the first listed.
NCT05456542 lists 5 locations in 3 states (Ontario, Texas, Other).
Frequently Asked Questions
What is clinical trial NCT05456542 about?
NCT05456542 is a clinical study titled "Cuff Leak Test and Airway Obstruction in Mechanically Ventilated ICU Patients". The COSMIC trial will be a multicentred, national, parallel-group, pragmatic vanguard pilot trial.
What is the current status of trial NCT05456542?
This trial is currently completed. It is a Phase 3 study. The enrollment target is 100 participants. The study started on 2023-04-05. Estimated completion is 2025-01-06.
What conditions does trial NCT05456542 study?
This clinical trial studies the following conditions: Respiratory Failure.
What interventions are being tested in trial NCT05456542?
The interventions under investigation include: Dexamethasone 4mg (DRUG), Cuff Leak Test (DIAGNOSTIC_TEST).
Who is sponsoring clinical trial NCT05456542?
This trial is sponsored by St. Joseph's Healthcare Hamilton, which has 3 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05456542 being conducted?
This trial has 5 study locations across Texas, Ontario. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Respiratory Failure
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05456542's enrollment target sits among peer trials
100 25th of 40 higher than 14 of 40 other Respiratory Failure trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Respiratory Failure trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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