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NCT06976307 · ClinicalTrials.gov registry record · NA
Development of an Inclusive Adaptive Treatment Strategy for Weight Loss in People With Prediabetes Using a Sequential Multiple Assignment Randomized Trial
A NA study of PreDiabetes and Obesity and Overweight, sponsored by University of Alabama at Birmingham.
- Recruiting
- Registry status
- NA
- Development phase
- 30
- Enrollment target
- 1
- Study location
NCT06976307: Recruiting NA study of PreDiabetes and Obesity and Overweight, sponsored by University of Alabama at Birmingham.
NCT06976307 is a NA study of PreDiabetes and Obesity and Overweight that is actively recruiting participants, run by University of Alabama at Birmingham. The registered enrollment target is 30 participants, below the 701-participant average among 149 other PreDiabetes trials with a reported enrollment target (96% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06976307, a NA study of PreDiabetes and Obesity and Overweight, is actively recruiting participants, sponsored by University of Alabama at Birmingham.
- RECRUITING
- Registry status
- NA
- Development phase
- 30 participants
- Enrollment target
- 1
- Study location
Study Summary
This is a sub-study to NCT04745572 to include a new cohort of participants with disabilities. This 16-week study will use an experimental approach called the Sequential Multiple Assignment Randomized Trial to help determine which combination and sequence of weight loss program features are most effective in people who are at risk for type 2 diabetes. Participants in the study will be initially randomized to consume either a high or reduced carbohydrate diet. After 4 weeks, participants will be identified as Responders (greater than or equal to 2.5% weight loss) or Non-Responders (less than 2.5% weight loss). Responders will continue with their initial randomized group for the remainder of the trial. Non-responders will be re-randomized to 2nd stage interventions of either including additional exercise counseling and training or beginning a time restricted eating protocol for the remainder of the trial.
Primary Outcome
Serum glucose will be measured in a fasted state.
Conditions Studied
Interventions
- BEHAVIORAL High Carbohydrate Diet
- BEHAVIORAL Reduced Carbohydrate Diet
Study Locations (1)
Alabama
- Wellness Health and Research Facility (WHARF) - Birmingham
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 30 participants |
| Start Date | 2026-03 |
| Est. Completion | 2026-07 |
| Phase | NA |
What NCT06976307 shows while recruiting
NCT06976307 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 30 participants, a relatively small participant target, below the 701-participant average among 149 other PreDiabetes trials with a reported enrollment target (96% lower).
The record links to 3 conditions, with PreDiabetes appearing as the primary indexed condition, and to 2 interventions - of which High Carbohydrate Diet is the first listed.
NCT06976307 reports a single indexed study location in Alabama.
Frequently Asked Questions
What is clinical trial NCT06976307 about?
NCT06976307 is a clinical study titled "Development of an Inclusive Adaptive Treatment Strategy for Weight Loss in People With Prediabetes Using a Sequential Multiple Assignment Randomized Trial". This is a sub-study to NCT04745572 to include a new cohort of participants with disabilities. This 16-week study will use an experimental approach called the Sequential Multiple Assignment Randomized Trial to help determine which combination and sequence of weight loss program features are most effe...
What is the current status of trial NCT06976307?
This trial is currently recruiting. It is a NA study. The enrollment target is 30 participants. The study started on 2026-03. Estimated completion is 2026-07.
What conditions does trial NCT06976307 study?
This clinical trial studies the following conditions: PreDiabetes, Obesity and Overweight, Disabilities.
What interventions are being tested in trial NCT06976307?
The interventions under investigation include: High Carbohydrate Diet (BEHAVIORAL), Reduced Carbohydrate Diet (BEHAVIORAL).
Who is sponsoring clinical trial NCT06976307?
This trial is sponsored by University of Alabama at Birmingham, which has 1,160 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06976307 being conducted?
This trial has 1 study location across Alabama. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for PreDiabetes
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06976307's enrollment target sits among peer trials
30 118th of 149 higher than 23 of 149 other PreDiabetes trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other PreDiabetes trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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