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ClinicalTrials.gov 29 recruiting now official registry

Osteoarthritis clinical trials

29 of 136 indexed Osteoarthritis trials are currently recruiting.

136 US clinical trials · 29 currently recruiting

Osteoarthritis is the subject of 136 registered US clinical trials on ClinicalTrials.gov, 29 of them currently open to new participants. 20 are in Phase 3-4 (later-stage) and 22 in Phase 1-2 (earlier-stage). The most active sponsor is Zimmer Biomet, running 12 of these trials.

The research picture

Osteoarthritis has 136 registered US clinical trials, 29 of them open to new participants right now, about 21% of the total.

29
recruiting participants now
21%
of trials open to enrollment
20
in Phase 3–4 (later-stage)
12
top sponsor: Zimmer Biomet
Phase 14Phase 218Phase 313Phase 47

Active & Recent Trials

136 total, page 2 of 3

ACTIVE NOT RECRUITING NA 60 participants

Impact of Different Exercise Programs on Knee OA

Shirley Ryan AbilityLab

NCT05844124

ACTIVE NOT RECRUITING 50 participants

Survivorship and Outcomes of Robotic-Arm Assisted Bicompartmental Arthroplasty

St. Helena Hospital Coon Joint Replacement Institute

NCT03668704

ACTIVE NOT RECRUITING 40 participants

PROs Following Low-dose Irradiation for Osteoarthritis

University of North Carolina, Chapel Hill

NCT05705947

COMPLETED 4,796 participants

Osteoarthritis Initiative (OAI): A Knee Health Study

National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

NCT00080171

COMPLETED NA 1,593 participants

Clinical Study Evaluating an Acetabular Cup System After Total Hip Replacement

DePuy Orthopaedics

NCT00306930

COMPLETED Phase 3 1,588 participants

Glucosamine/Chondroitin Arthritis Intervention Trial (GAIT)

US Department of Veterans Affairs

NCT00032890

COMPLETED Phase 3 1,164 participants

To Study Generic Diclofenac Sodium Topical Gel 1% in the Treatment of Osteoarthritis of the Knee (Degenerative Joint Disease Presented as Joint Pain, Stiffness, Swelling and Restricted Motion).

Glenmark Pharmaceuticals Ltd. India

NCT02596451

COMPLETED NA 1,133 participants

Postoperative Hip Precautions After Total Hip Arthroplasty Via the Posterior Approach: A Prospective Randomized Trial

Rush University Medical Center

NCT02686528

COMPLETED 980 participants

Understanding the Differences in the Management of Patients With Arthritis of the Knee or Hip

US Department of Veterans Affairs

NCT00105677

COMPLETED NA 900 participants

Development and Evaluation of A Mailed Arthritis Self-Management Program

University of North Carolina

NCT00448474

COMPLETED 873 participants

A Single Time-Point Study to Evaluate the ConforMIS iTotal® (CR) Knee Versus Off-the-Shelf

Restor3D

NCT02251522

COMPLETED Phase 3 679 participants

Efficacy of ThermoProfen in Patients With Mild to Moderate Pain Associated With Osteoarthritis of the Knee

ZARS Pharma

NCT00488267

COMPLETED Phase 3 650 participants

Study Evaluating the Efficacy and Safety of Topical Diclofenac Spray in Osteoarthritis of the Knee: Trial I

Mika Pharma

NCT00546507

COMPLETED NA 639 participants

Interaction Between Patient and Healthcare Provider: Response to Acupuncture in Knee Osteoarthritis

M.D. Anderson Cancer Center

NCT00059345

COMPLETED 617 participants

Periodontal Disease and P. Gingivalis in Rheumatoid Arthritis

University of Nebraska

NCT01156155

COMPLETED Phase 3 614 participants

Efficacy Study of PN400 (VIMOVO) Twice Daily and Celebrex Once Daily in Patients With Osteoarthritis

POZEN

NCT00664560

COMPLETED NA 537 participants

Patient and Provider Interventions for Managing Osteoarthritis in Primary Care

Duke University

NCT01435109

COMPLETED Phase 2 534 participants

Rates of Gastric Ulcer by Endoscopy in Knee Osteoarthritis Patients Receiving LT-NS001 Versus Naprosyn®

Logical Therapeutics

NCT01063920

COMPLETED NA 523 participants

Self-Management of Osteoarthritis

US Department of Veterans Affairs

NCT00288912

COMPLETED NA 413 participants

Fit and Strong! Plus Comparative Effectiveness Trial

University of Illinois at Chicago

NCT03180008

COMPLETED NA 395 participants

Trial Outcomes for Massage: Caregiver-Assisted vs. Therapist-Treated

VA Office of Research and Development

NCT03100539

COMPLETED 388 participants

A Clinical Investigation of the Oxford® Meniscal Unicompartmental Knee System

Biomet Orthopedics

NCT00578994

COMPLETED Phase 3 376 participants

Study of COV795 in Subjects With Osteoarthritis or Chronic Low Back Pain

Mallinckrodt

NCT01451385

COMPLETED NA 367 participants

Cognitive Behavioral Therapy for Arthritis Pain and Insomnia in Older Adults

University of Washington

NCT01142349

COMPLETED NA 350 participants

Study of Flavocoxid (Limbrel) vs Naproxen in Subjects With Mod-Severe Osteoarthritis of the Knee

Primus Pharmaceuticals

NCT00435292

COMPLETED Phase 3 290 participants

Safety of BTDS in Subjects With Osteoarthritic (OA) Pain of Hip or Knee: A 6-Month Open-label Extension Phase

Purdue Pharma

NCT01141283

COMPLETED NA 266 participants

Actis Total Hip System 2 Year Follow-up

DePuy Orthopaedics

NCT02783274

COMPLETED NA 265 participants

Strategies for Prescribing Analgesics Comparative Effectiveness Trial

VA Office of Research and Development

NCT01583985

COMPLETED NA 236 participants

Study Comparing Marathon Polyethylene and Enduron Polyethylene Acetabular Liners Used in Total Hip Arthroplasty

Anderson Orthopaedic Research Institute

NCT01121146

COMPLETED Phase 2 231 participants

Knee Stability Training for Knee Osteoarthritis (OA)

University of Pittsburgh

NCT00078624

COMPLETED 231 participants

Post-PMA Approval Study: 10 Year Follow-Up IDE Subjects

Corin

NCT00721994

COMPLETED NA 230 participants

Marathon and Enduron Polyethylene at Long-Term Follow-up

Anderson Orthopaedic Research Institute

NCT02508428

COMPLETED Phase 3 225 participants

The Safety and Efficacy of the Buprenorphine Transdermal Delivery System in Subjects With Osteoarthritis Pain.

Purdue Pharma

NCT00315848

COMPLETED Phase 2 217 participants

Impact of Exercise on Older Persons With Osteoarthritis

National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

NCT00000434

COMPLETED NA 210 participants

Clinical Investigation of the LCS® Complete Posterior Stabilized Mobile-bearing Total Knee System

DePuy Orthopaedics

NCT00487565

COMPLETED Phase 2 202 participants

Chronic Pain Master Protocol (CPMP): A Study of LY3556050 in Participants With Osteoarthritis

Eli Lilly and Company

NCT04627038

COMPLETED NA 201 participants

Breaking Implicit Bias Habits: An Individuation Pilot Study In Rheumatology

Brigham and Women's Hospital

NCT05116163

COMPLETED Phase 4 194 participants

Clinical Efficacy of Tranexamic Acid and ε-Aminocaproic Acid in Reducing Blood Loss Following Total Knee Replacement

Miller Orthopedic Specialists

NCT01873768

COMPLETED NA 187 participants

Quality IQ Patient Simulation Physician Practice Measurement and Engagement

Qure Healthcare

NCT03800901

COMPLETED NA 184 participants

Manual Therapy and Strengthening for the Hip in Older Adults With Chronic Low Back Pain

University of Delaware

NCT04009837

COMPLETED Phase 2 175 participants

Study to Evaluate the Safety and Efficacy of CNTX-4975 in Subjects With Chronic, Moderate to Severe Osteoarthritis Knee Pain

Centrexion Therapeutics

NCT02558439

COMPLETED NA 160 participants

NexGen TM Tibia Clinical Outcomes Study

Zimmer Biomet

NCT03272373

COMPLETED NA 159 participants

Single Shot vs 24hr vs 48hr Continuous Adductor Canal Block After TKA

University of Pennsylvania

NCT02730728

COMPLETED NA 155 participants

Evaluation of DVD and Internet Decision Aids for Hip and Knee Osteoarthritis: Focus on Health Literacy

Duke University

NCT01618097

COMPLETED Phase 3 154 participants

Long-term Observational Study of Subjects From Tanezumab Studies Who Undergo a Total Knee, Hip or Shoulder Replacement

Pfizer

NCT02674386

COMPLETED NA 150 participants

Acupressure for Knee Pain in Older Adults

University of Michigan

NCT02003443

COMPLETED Phase 4 150 participants

TREAD-20: Trial of Hyalgan Three Injection-Regimen for the Treatment of Knee Pain Due to Osteoarthritis

Sanofi

NCT00130468

COMPLETED 149 participants

A Clinical Investigation of ArComXL® Polyethylene in Total Hip Replacement

Zimmer Biomet

NCT00698152

COMPLETED Phase 2 124 participants

A Study of the Efficacy and Safety of VX-150 in Subjects With Osteoarthritis of the Knee

Vertex Pharmaceuticals Incorporated

NCT02660424

COMPLETED NA 113 participants

Internet-Based Osteoarthritis Pain Coping Skills Intervention

University of North Carolina, Chapel Hill

NCT01638871

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Phase Distribution

PhaseTrial count
Phase 1 4
Phase 2 18
Phase 3 13
Phase 4 7

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Osteoarthritis Trial Landscape

136 indexed Osteoarthritis studies · 29 recruiting (21%).

Phase mix: 20 late (III/IV) vs 22 early (I/II).

Top sponsor: Zimmer Biomet (12 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Osteoarthritis?

PlainTrial tracks 136 US clinical trials for Osteoarthritis, of which 29 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Osteoarthritis?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.