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Osteoarthritis: full-pipeline trial registry
29 of 136 indexed Osteoarthritis trials are currently recruiting.
Corpus placement: #84 of 28,707 conditions by registered trial count.
136 US clinical trials · 29 currently recruiting · #84 of 28,707 conditions by registered trial count
Osteoarthritis: 136 US clinical trials tracked, 29 recruiting.
Osteoarthritis is the subject of 136 registered US clinical trials on ClinicalTrials.gov, 29 of them currently open to new participants. 20 are in Phase 3-4 (later-stage) and 22 in Phase 1-2 (earlier-stage). The most active sponsor is Zimmer Biomet, running 12 of these trials.
Enrollment posture brief
Registry condition osteoarthritis
OPEN 29 | RECR 21% | LATE 20 | EARLY 22 | RANK #84 | SPON 12
Volume-matched condition peers
Nearest open-share peer: Alcohol Abuse (21% recruiting · 47 trials)
Osteoarthritis lists 29 open slots (21% of 136 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Osteoarthritis on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Osteoarthritis is recruiting below its size-band peers.
29 of 136 indexed trials (21.3%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Osteoarthritis trials is spread across many organizations.
Zimmer Biomet accounts for 12 of 136 trials (8.8%). 87 distinct sponsors appear on at least one study for this condition label.
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Typical Osteoarthritis enrolment sits around 160 participants.
Median target enrolment is 160 among the 136 trials that report a genuine target (sentinel values excluded). 45 of those (33.1%) plan for fewer than 100 participants.
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Osteoarthritis research is mostly interventional.
106 interventional and 30 observational studies make up this index (77.9% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
136 total, page 2 of 3
Impact of Different Exercise Programs on Knee OA
Shirley Ryan AbilityLab
NCT05844124
Survivorship and Outcomes of Robotic-Arm Assisted Bicompartmental Arthroplasty
St. Helena Hospital Coon Joint Replacement Institute
NCT03668704
PROs Following Low-dose Irradiation for Osteoarthritis
University of North Carolina, Chapel Hill
NCT05705947
Osteoarthritis Initiative (OAI): A Knee Health Study
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
NCT00080171
Clinical Study Evaluating an Acetabular Cup System After Total Hip Replacement
DePuy Orthopaedics
NCT00306930
Glucosamine/Chondroitin Arthritis Intervention Trial (GAIT)
US Department of Veterans Affairs
NCT00032890
To Study Generic Diclofenac Sodium Topical Gel 1% in the Treatment of Osteoarthritis of the Knee (Degenerative Joint Disease Presented as Joint Pain, Stiffness, Swelling and Restricted Motion).
Glenmark Pharmaceuticals Ltd. India
NCT02596451
Postoperative Hip Precautions After Total Hip Arthroplasty Via the Posterior Approach: A Prospective Randomized Trial
Rush University Medical Center
NCT02686528
Understanding the Differences in the Management of Patients With Arthritis of the Knee or Hip
US Department of Veterans Affairs
NCT00105677
Development and Evaluation of A Mailed Arthritis Self-Management Program
University of North Carolina
NCT00448474
A Single Time-Point Study to Evaluate the ConforMIS iTotal® (CR) Knee Versus Off-the-Shelf
Restor3D
NCT02251522
Efficacy of ThermoProfen in Patients With Mild to Moderate Pain Associated With Osteoarthritis of the Knee
ZARS Pharma
NCT00488267
Study Evaluating the Efficacy and Safety of Topical Diclofenac Spray in Osteoarthritis of the Knee: Trial I
Mika Pharma
NCT00546507
Interaction Between Patient and Healthcare Provider: Response to Acupuncture in Knee Osteoarthritis
M.D. Anderson Cancer Center
NCT00059345
Periodontal Disease and P. Gingivalis in Rheumatoid Arthritis
University of Nebraska
NCT01156155
Efficacy Study of PN400 (VIMOVO) Twice Daily and Celebrex Once Daily in Patients With Osteoarthritis
POZEN
NCT00664560
Patient and Provider Interventions for Managing Osteoarthritis in Primary Care
Duke University
NCT01435109
Rates of Gastric Ulcer by Endoscopy in Knee Osteoarthritis Patients Receiving LT-NS001 Versus Naprosyn®
Logical Therapeutics
NCT01063920
Self-Management of Osteoarthritis
US Department of Veterans Affairs
NCT00288912
Fit and Strong! Plus Comparative Effectiveness Trial
University of Illinois at Chicago
NCT03180008
Trial Outcomes for Massage: Caregiver-Assisted vs. Therapist-Treated
VA Office of Research and Development
NCT03100539
A Clinical Investigation of the Oxford® Meniscal Unicompartmental Knee System
Biomet Orthopedics
NCT00578994
Study of COV795 in Subjects With Osteoarthritis or Chronic Low Back Pain
Mallinckrodt
NCT01451385
Cognitive Behavioral Therapy for Arthritis Pain and Insomnia in Older Adults
University of Washington
NCT01142349
Study of Flavocoxid (Limbrel) vs Naproxen in Subjects With Mod-Severe Osteoarthritis of the Knee
Primus Pharmaceuticals
NCT00435292
Safety of BTDS in Subjects With Osteoarthritic (OA) Pain of Hip or Knee: A 6-Month Open-label Extension Phase
Purdue Pharma
NCT01141283
Actis Total Hip System 2 Year Follow-up
DePuy Orthopaedics
NCT02783274
Strategies for Prescribing Analgesics Comparative Effectiveness Trial
VA Office of Research and Development
NCT01583985
Study Comparing Marathon Polyethylene and Enduron Polyethylene Acetabular Liners Used in Total Hip Arthroplasty
Anderson Orthopaedic Research Institute
NCT01121146
Knee Stability Training for Knee Osteoarthritis (OA)
University of Pittsburgh
NCT00078624
Post-PMA Approval Study: 10 Year Follow-Up IDE Subjects
Corin
NCT00721994
Marathon and Enduron Polyethylene at Long-Term Follow-up
Anderson Orthopaedic Research Institute
NCT02508428
The Safety and Efficacy of the Buprenorphine Transdermal Delivery System in Subjects With Osteoarthritis Pain.
Purdue Pharma
NCT00315848
Impact of Exercise on Older Persons With Osteoarthritis
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
NCT00000434
Clinical Investigation of the LCS® Complete Posterior Stabilized Mobile-bearing Total Knee System
DePuy Orthopaedics
NCT00487565
Chronic Pain Master Protocol (CPMP): A Study of LY3556050 in Participants With Osteoarthritis
Eli Lilly and Company
NCT04627038
Breaking Implicit Bias Habits: An Individuation Pilot Study In Rheumatology
Brigham and Women's Hospital
NCT05116163
Clinical Efficacy of Tranexamic Acid and ε-Aminocaproic Acid in Reducing Blood Loss Following Total Knee Replacement
Miller Orthopedic Specialists
NCT01873768
Quality IQ Patient Simulation Physician Practice Measurement and Engagement
Qure Healthcare
NCT03800901
Manual Therapy and Strengthening for the Hip in Older Adults With Chronic Low Back Pain
University of Delaware
NCT04009837
Study to Evaluate the Safety and Efficacy of CNTX-4975 in Subjects With Chronic, Moderate to Severe Osteoarthritis Knee Pain
Centrexion Therapeutics
NCT02558439
NexGen TM Tibia Clinical Outcomes Study
Zimmer Biomet
NCT03272373
Single Shot vs 24hr vs 48hr Continuous Adductor Canal Block After TKA
University of Pennsylvania
NCT02730728
Evaluation of DVD and Internet Decision Aids for Hip and Knee Osteoarthritis: Focus on Health Literacy
Duke University
NCT01618097
Long-term Observational Study of Subjects From Tanezumab Studies Who Undergo a Total Knee, Hip or Shoulder Replacement
Pfizer
NCT02674386
Acupressure for Knee Pain in Older Adults
University of Michigan
NCT02003443
TREAD-20: Trial of Hyalgan Three Injection-Regimen for the Treatment of Knee Pain Due to Osteoarthritis
Sanofi
NCT00130468
A Clinical Investigation of ArComXL® Polyethylene in Total Hip Replacement
Zimmer Biomet
NCT00698152
A Study of the Efficacy and Safety of VX-150 in Subjects With Osteoarthritis of the Knee
Vertex Pharmaceuticals Incorporated
NCT02660424
Internet-Based Osteoarthritis Pain Coping Skills Intervention
University of North Carolina, Chapel Hill
NCT01638871
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 4 |
| Phase 2 | 18 |
| Phase 3 | 13 |
| Phase 4 | 7 |
Top Sponsors
Named interventions
Most-linked intervention names on Osteoarthritis records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Osteoarthritis trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Osteoarthritis page
136 registered trials, 29 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 29 Osteoarthritis trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Zimmer Biomet sponsors the most Osteoarthritis trials on record, review their full trial history before evaluating a specific study. See Zimmer Biomet's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Osteoarthritis condition card totals 136 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.