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ClinicalTrials.gov 29 recruiting now official registry

Osteoarthritis clinical trials

29 of 136 indexed Osteoarthritis trials are currently recruiting.

136 US clinical trials · 29 currently recruiting

Osteoarthritis is the subject of 136 registered US clinical trials on ClinicalTrials.gov, 29 of them currently open to new participants. 20 are in Phase 3-4 (later-stage) and 22 in Phase 1-2 (earlier-stage). The most active sponsor is Zimmer Biomet, running 12 of these trials.

The research picture

Osteoarthritis has 136 registered US clinical trials, 29 of them open to new participants right now, about 21% of the total.

29
recruiting participants now
21%
of trials open to enrollment
20
in Phase 3–4 (later-stage)
12
top sponsor: Zimmer Biomet
Phase 14Phase 218Phase 313Phase 47

Active & Recent Trials

136 total, page 3 of 3

COMPLETED Phase 4 111 participants

The Combination of Adductor Canal Block and Periarticular Injection. A Novel Technique for Patients Undergoing Total Knee Replacement (ACB PAI)

Hospital for Special Surgery, New York

NCT02292082

COMPLETED NA 102 participants

2-Year Post-Approval Study to Investigate the Scandinavian Total Ankle Replacement System (STAR) Ankle Under Actual Conditions of Use

Encore Medical, L.P.

NCT01284283

COMPLETED NA 100 participants

Robotic Arm Assisted Total Knee Arthroplasty

MAKO Surgical

NCT02058069

COMPLETED NA 100 participants

Anterior Referencing Versus Posterior Referencing in Minimally Invasive Total Knee Arthroplasty

Heekin Orthopedic Research Institute

NCT01135030

COMPLETED NA 95 participants

Improving Rehabilitation Outcomes After Total Hip Arthroplasty

VA Office of Research and Development

NCT02920866

COMPLETED 89 participants

A Retrospective Study of the iTotal CR Knee Replacement System

Restor3D

NCT01564654

COMPLETED 88 participants

Osteoarthritis: Weakness From Inflammation

National Institute on Aging (NIA)

NCT00104312

COMPLETED 83 participants

Continuum™ Metal Bearing System in Total Hip Arthroplasty

Zimmer Biomet

NCT03382652

COMPLETED 81 participants

Ceramic On Ceramic (COC) 36mm PAS IDE Rollover Subjects; Ceramic Acetabular Bearing With Ceramic Femoral Head in Total Hip Replacement

DePuy Orthopaedics

NCT02096198

COMPLETED NA 80 participants

Study of Antibiotic Spacer Design to Treat Infection After Hip Replacement

Rush University Medical Center

NCT01373099

COMPLETED NA 80 participants

Overcoming TWEAK Signaling to Restore Muscle and Mobility After Joint Replacement

University of Alabama at Birmingham

NCT02628795

COMPLETED Phase 2 79 participants

Double-Blind,Randomized,Placebo-Controlled Efficacy & Safety Study of EUFLEXXA™ for Treatment of OA of the First CMC

Ferring Pharmaceuticals

NCT00423371

COMPLETED 76 participants

Ankle Joint Replacement Outcomes Study

Smith & Nephew

NCT00503438

COMPLETED Phase 2 75 participants

FolateScan in Autoimmune Disease

Mayo Clinic

NCT00588393

COMPLETED NA 72 participants

Study Comparing Mini-Incision Versus 2-Incision Approach for Total Hip Replacement

Rush University Medical Center

NCT00594893

COMPLETED 66 participants

Comparison of Knee Kinematics for Subjects Implanted With Either a ConforMIS or Traditional Knee Implant

Restor3D

NCT01717001

COMPLETED NA 65 participants

Study of Effectiveness of Hand Exercises to Treat Symptoms of Hand Osteoarthritis

The Arthritis Research Institute of America

NCT00375947

COMPLETED Phase 2 60 participants

Synvisc to Treat Osteoarthritis of the Temporomandibular Joint

National Institute of Dental and Craniofacial Research (NIDCR)

NCT00078351

COMPLETED NA 56 participants

Adductor Canal Block With Posterior Capsular Injection for Total Knee Replacement

Trinity Health Of New England

NCT01805661

COMPLETED NA 54 participants

Exercise Plus Activity Strategy Training for Osteoarthritis

University of Michigan

NCT00613678

COMPLETED NA 50 participants

Imaging Biomarkers of Knee Osteoarthritis

NYU Langone Health

NCT02888119

COMPLETED NA 49 participants

The Effect of Transcutaneous Electrical Nerve Stimulation on Quadriceps Central Activation and Gait

University of Virginia

NCT00976079

COMPLETED NA 44 participants

Lumbar Plexus Block Versus Quadratus Lumborum Block for Primary Anterior Total Hip Arthroplasty

Wake Forest University Health Sciences

NCT03409900

COMPLETED Phase 4 40 participants

Duloxetine in Osteoarthritis (OA) Pain

Northwestern University

NCT01558700

COMPLETED Phase 2 40 participants

Effectiveness of Two Types of Treatment in Restoring Muscle After Hip or Knee Surgery

University of Arkansas

NCT00393848

COMPLETED NA 40 participants

A Randomized, Double-Blind, Controlled Trial to Assess the Efficacy of a Fortetropin Supplement in Improving Symptoms of Osteoarthritis

MYOS

NCT06021665

COMPLETED NA 38 participants

Geniculate Artery Embolization for Treatment of Osteoarthritis

NYU Langone Health

NCT04379700

COMPLETED NA 38 participants

Home Telerehabilitation for Deconditioned Older Adults

US Department of Veterans Affairs

NCT00386256

COMPLETED NA 30 participants

Insomnia and Osteoarthritis Study

Johns Hopkins University

NCT00374556

COMPLETED Phase 1 30 participants

A Study With GLPG1972 in Osteoarthritis Subjects

Galapagos

NCT03311009

COMPLETED Phase 2 29 participants

Low Dose Naltrexone for Chronic Pain From Arthritis

VA Office of Research and Development

NCT03008590

COMPLETED NA 24 participants

Group Physical Therapy for Knee Osteoarthritis

US Department of Veterans Affairs

NCT00642772

COMPLETED Phase 3 24 participants

Allograft Transplantation in the Treatment of Osteoarthritis of the Metatarsophalangeal (MTP) Joint of the Great Toe

Paul Fortin, MD

NCT01673347

COMPLETED Phase 1 20 participants

Autologous Alpha-2 Macroglobulin Rich Plasma, Safety and Efficacy in Symptomatic Moderate Knee Osteoarthritis

Mayo Clinic

NCT06329492

COMPLETED 18 participants

A Longitudinal Study of Osteoarthritis (OA) Disease Progression Measured by MRI, dGEMRIC, and Radiography

University of California, San Francisco

NCT00505297

COMPLETED Phase 1 5 participants

Translating Metabolic Responses to Mechanical Insult Into Early Interventions to Prevent PTOA

J L Marsh

NCT04589611

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Phase Distribution

PhaseTrial count
Phase 1 4
Phase 2 18
Phase 3 13
Phase 4 7

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Osteoarthritis Trial Landscape

136 indexed Osteoarthritis studies · 29 recruiting (21%).

Phase mix: 20 late (III/IV) vs 22 early (I/II).

Top sponsor: Zimmer Biomet (12 trials), 9 others listed. 36 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Osteoarthritis?

PlainTrial tracks 136 US clinical trials for Osteoarthritis, of which 29 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Osteoarthritis?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.