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Osteoarthritis clinical trials
29 of 136 indexed Osteoarthritis trials are currently recruiting.
136 US clinical trials · 29 currently recruiting
Osteoarthritis is the subject of 136 registered US clinical trials on ClinicalTrials.gov, 29 of them currently open to new participants. 20 are in Phase 3-4 (later-stage) and 22 in Phase 1-2 (earlier-stage). The most active sponsor is Zimmer Biomet, running 12 of these trials.
The research picture
Osteoarthritis has 136 registered US clinical trials, 29 of them open to new participants right now, about 21% of the total.
- 29
- recruiting participants now
- 21%
- of trials open to enrollment
- 20
- in Phase 3–4 (later-stage)
- 12
- top sponsor: Zimmer Biomet
Active & Recent Trials
136 total, page 3 of 3
The Combination of Adductor Canal Block and Periarticular Injection. A Novel Technique for Patients Undergoing Total Knee Replacement (ACB PAI)
Hospital for Special Surgery, New York
NCT02292082
2-Year Post-Approval Study to Investigate the Scandinavian Total Ankle Replacement System (STAR) Ankle Under Actual Conditions of Use
Encore Medical, L.P.
NCT01284283
Robotic Arm Assisted Total Knee Arthroplasty
MAKO Surgical
NCT02058069
Anterior Referencing Versus Posterior Referencing in Minimally Invasive Total Knee Arthroplasty
Heekin Orthopedic Research Institute
NCT01135030
Improving Rehabilitation Outcomes After Total Hip Arthroplasty
VA Office of Research and Development
NCT02920866
A Retrospective Study of the iTotal CR Knee Replacement System
Restor3D
NCT01564654
Osteoarthritis: Weakness From Inflammation
National Institute on Aging (NIA)
NCT00104312
Continuum™ Metal Bearing System in Total Hip Arthroplasty
Zimmer Biomet
NCT03382652
Ceramic On Ceramic (COC) 36mm PAS IDE Rollover Subjects; Ceramic Acetabular Bearing With Ceramic Femoral Head in Total Hip Replacement
DePuy Orthopaedics
NCT02096198
Study of Antibiotic Spacer Design to Treat Infection After Hip Replacement
Rush University Medical Center
NCT01373099
Overcoming TWEAK Signaling to Restore Muscle and Mobility After Joint Replacement
University of Alabama at Birmingham
NCT02628795
Double-Blind,Randomized,Placebo-Controlled Efficacy & Safety Study of EUFLEXXA™ for Treatment of OA of the First CMC
Ferring Pharmaceuticals
NCT00423371
Ankle Joint Replacement Outcomes Study
Smith & Nephew
NCT00503438
FolateScan in Autoimmune Disease
Mayo Clinic
NCT00588393
Study Comparing Mini-Incision Versus 2-Incision Approach for Total Hip Replacement
Rush University Medical Center
NCT00594893
Comparison of Knee Kinematics for Subjects Implanted With Either a ConforMIS or Traditional Knee Implant
Restor3D
NCT01717001
Study of Effectiveness of Hand Exercises to Treat Symptoms of Hand Osteoarthritis
The Arthritis Research Institute of America
NCT00375947
Synvisc to Treat Osteoarthritis of the Temporomandibular Joint
National Institute of Dental and Craniofacial Research (NIDCR)
NCT00078351
Adductor Canal Block With Posterior Capsular Injection for Total Knee Replacement
Trinity Health Of New England
NCT01805661
Exercise Plus Activity Strategy Training for Osteoarthritis
University of Michigan
NCT00613678
Imaging Biomarkers of Knee Osteoarthritis
NYU Langone Health
NCT02888119
The Effect of Transcutaneous Electrical Nerve Stimulation on Quadriceps Central Activation and Gait
University of Virginia
NCT00976079
Lumbar Plexus Block Versus Quadratus Lumborum Block for Primary Anterior Total Hip Arthroplasty
Wake Forest University Health Sciences
NCT03409900
Duloxetine in Osteoarthritis (OA) Pain
Northwestern University
NCT01558700
Effectiveness of Two Types of Treatment in Restoring Muscle After Hip or Knee Surgery
University of Arkansas
NCT00393848
A Randomized, Double-Blind, Controlled Trial to Assess the Efficacy of a Fortetropin Supplement in Improving Symptoms of Osteoarthritis
MYOS
NCT06021665
Geniculate Artery Embolization for Treatment of Osteoarthritis
NYU Langone Health
NCT04379700
Home Telerehabilitation for Deconditioned Older Adults
US Department of Veterans Affairs
NCT00386256
Insomnia and Osteoarthritis Study
Johns Hopkins University
NCT00374556
A Study With GLPG1972 in Osteoarthritis Subjects
Galapagos
NCT03311009
Low Dose Naltrexone for Chronic Pain From Arthritis
VA Office of Research and Development
NCT03008590
Group Physical Therapy for Knee Osteoarthritis
US Department of Veterans Affairs
NCT00642772
Allograft Transplantation in the Treatment of Osteoarthritis of the Metatarsophalangeal (MTP) Joint of the Great Toe
Paul Fortin, MD
NCT01673347
Autologous Alpha-2 Macroglobulin Rich Plasma, Safety and Efficacy in Symptomatic Moderate Knee Osteoarthritis
Mayo Clinic
NCT06329492
A Longitudinal Study of Osteoarthritis (OA) Disease Progression Measured by MRI, dGEMRIC, and Radiography
University of California, San Francisco
NCT00505297
Translating Metabolic Responses to Mechanical Insult Into Early Interventions to Prevent PTOA
J L Marsh
NCT04589611
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 4 |
| Phase 2 | 18 |
| Phase 3 | 13 |
| Phase 4 | 7 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Osteoarthritis Trial Landscape
136 indexed Osteoarthritis studies · 29 recruiting (21%).
Phase mix: 20 late (III/IV) vs 22 early (I/II).
Top sponsor: Zimmer Biomet (12 trials), 9 others listed. 36 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Osteoarthritis?
PlainTrial tracks 136 US clinical trials for Osteoarthritis, of which 29 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Osteoarthritis?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.