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Osteoarthritis: full-pipeline trial registry
29 of 136 indexed Osteoarthritis trials are currently recruiting.
Corpus placement: #84 of 28,707 conditions by registered trial count.
136 US clinical trials · 29 currently recruiting · #84 of 28,707 conditions by registered trial count
Osteoarthritis: 136 US clinical trials tracked, 29 recruiting.
Osteoarthritis is the subject of 136 registered US clinical trials on ClinicalTrials.gov, 29 of them currently open to new participants. 20 are in Phase 3-4 (later-stage) and 22 in Phase 1-2 (earlier-stage). The most active sponsor is Zimmer Biomet, running 12 of these trials.
Enrollment posture brief
Registry condition osteoarthritis
OPEN 29 | RECR 21% | LATE 20 | EARLY 22 | RANK #84 | SPON 12
Volume-matched condition peers
Nearest open-share peer: Alcohol Abuse (21% recruiting · 47 trials)
Osteoarthritis lists 29 open slots (21% of 136 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Osteoarthritis on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Osteoarthritis is recruiting below its size-band peers.
29 of 136 indexed trials (21.3%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Osteoarthritis trials is spread across many organizations.
Zimmer Biomet accounts for 12 of 136 trials (8.8%). 87 distinct sponsors appear on at least one study for this condition label.
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Typical Osteoarthritis enrolment sits around 160 participants.
Median target enrolment is 160 among the 136 trials that report a genuine target (sentinel values excluded). 45 of those (33.1%) plan for fewer than 100 participants.
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Osteoarthritis research is mostly interventional.
106 interventional and 30 observational studies make up this index (77.9% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
136 total, page 3 of 3
The Combination of Adductor Canal Block and Periarticular Injection. A Novel Technique for Patients Undergoing Total Knee Replacement (ACB PAI)
Hospital for Special Surgery, New York
NCT02292082
2-Year Post-Approval Study to Investigate the Scandinavian Total Ankle Replacement System (STAR) Ankle Under Actual Conditions of Use
Encore Medical, L.P.
NCT01284283
Robotic Arm Assisted Total Knee Arthroplasty
MAKO Surgical
NCT02058069
Anterior Referencing Versus Posterior Referencing in Minimally Invasive Total Knee Arthroplasty
Heekin Orthopedic Research Institute
NCT01135030
Improving Rehabilitation Outcomes After Total Hip Arthroplasty
VA Office of Research and Development
NCT02920866
A Retrospective Study of the iTotal CR Knee Replacement System
Restor3D
NCT01564654
Osteoarthritis: Weakness From Inflammation
National Institute on Aging (NIA)
NCT00104312
Continuum™ Metal Bearing System in Total Hip Arthroplasty
Zimmer Biomet
NCT03382652
Ceramic On Ceramic (COC) 36mm PAS IDE Rollover Subjects; Ceramic Acetabular Bearing With Ceramic Femoral Head in Total Hip Replacement
DePuy Orthopaedics
NCT02096198
Study of Antibiotic Spacer Design to Treat Infection After Hip Replacement
Rush University Medical Center
NCT01373099
Overcoming TWEAK Signaling to Restore Muscle and Mobility After Joint Replacement
University of Alabama at Birmingham
NCT02628795
Double-Blind,Randomized,Placebo-Controlled Efficacy & Safety Study of EUFLEXXA™ for Treatment of OA of the First CMC
Ferring Pharmaceuticals
NCT00423371
Ankle Joint Replacement Outcomes Study
Smith & Nephew
NCT00503438
FolateScan in Autoimmune Disease
Mayo Clinic
NCT00588393
Study Comparing Mini-Incision Versus 2-Incision Approach for Total Hip Replacement
Rush University Medical Center
NCT00594893
Comparison of Knee Kinematics for Subjects Implanted With Either a ConforMIS or Traditional Knee Implant
Restor3D
NCT01717001
Study of Effectiveness of Hand Exercises to Treat Symptoms of Hand Osteoarthritis
The Arthritis Research Institute of America
NCT00375947
Synvisc to Treat Osteoarthritis of the Temporomandibular Joint
National Institute of Dental and Craniofacial Research (NIDCR)
NCT00078351
Adductor Canal Block With Posterior Capsular Injection for Total Knee Replacement
Trinity Health Of New England
NCT01805661
Exercise Plus Activity Strategy Training for Osteoarthritis
University of Michigan
NCT00613678
Imaging Biomarkers of Knee Osteoarthritis
NYU Langone Health
NCT02888119
The Effect of Transcutaneous Electrical Nerve Stimulation on Quadriceps Central Activation and Gait
University of Virginia
NCT00976079
Lumbar Plexus Block Versus Quadratus Lumborum Block for Primary Anterior Total Hip Arthroplasty
Wake Forest University Health Sciences
NCT03409900
Duloxetine in Osteoarthritis (OA) Pain
Northwestern University
NCT01558700
Effectiveness of Two Types of Treatment in Restoring Muscle After Hip or Knee Surgery
University of Arkansas
NCT00393848
A Randomized, Double-Blind, Controlled Trial to Assess the Efficacy of a Fortetropin Supplement in Improving Symptoms of Osteoarthritis
MYOS
NCT06021665
Geniculate Artery Embolization for Treatment of Osteoarthritis
NYU Langone Health
NCT04379700
Home Telerehabilitation for Deconditioned Older Adults
US Department of Veterans Affairs
NCT00386256
Insomnia and Osteoarthritis Study
Johns Hopkins University
NCT00374556
A Study With GLPG1972 in Osteoarthritis Subjects
Galapagos
NCT03311009
Low Dose Naltrexone for Chronic Pain From Arthritis
VA Office of Research and Development
NCT03008590
Group Physical Therapy for Knee Osteoarthritis
US Department of Veterans Affairs
NCT00642772
Allograft Transplantation in the Treatment of Osteoarthritis of the Metatarsophalangeal (MTP) Joint of the Great Toe
Paul Fortin, MD
NCT01673347
Autologous Alpha-2 Macroglobulin Rich Plasma, Safety and Efficacy in Symptomatic Moderate Knee Osteoarthritis
Mayo Clinic
NCT06329492
A Longitudinal Study of Osteoarthritis (OA) Disease Progression Measured by MRI, dGEMRIC, and Radiography
University of California, San Francisco
NCT00505297
Translating Metabolic Responses to Mechanical Insult Into Early Interventions to Prevent PTOA
J L Marsh
NCT04589611
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 4 |
| Phase 2 | 18 |
| Phase 3 | 13 |
| Phase 4 | 7 |
Top Sponsors
Named interventions
Most-linked intervention names on Osteoarthritis records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Osteoarthritis trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Osteoarthritis page
136 registered trials, 29 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 29 Osteoarthritis trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Zimmer Biomet sponsors the most Osteoarthritis trials on record, review their full trial history before evaluating a specific study. See Zimmer Biomet's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Osteoarthritis condition card totals 136 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.