Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

RECRUITING Phase 3

Efficacy and Safety of Eloralintide (LY3841136) in Participants With Osteoarthritis Knee Pain and Obesity or Overweight

NCT07353931 · View on ClinicalTrials.gov ↗

Study Summary

The YDAN master protocol will support two independent studies, J3R-MC-YOA1 and J3R-MC-YOA2. Each study will investigate how well and safely Eloralintide (LY3841136) works in adults with obesity or overweight who have osteoarthritis (OA) of the knee with pain. Participation in the study will last about 75 weeks, including screening.

Interventions

  • DRUG Placebo
  • DRUG Eloralintide

Study Locations (20)

California

  • Ark Clinical Research - Fountain Valley — Fountain Valley
  • Wolverine Clinical Trials — Santa Ana
  • Encompass Clinical Research — Spring Valley
  • Diablo Clinical Research, Inc. — Walnut Creek

Arizona

  • Care Access - 801 South Power Road, Mesa — Mesa
  • Elite Pain and Spine Institute - South Crimson Road — Mesa
  • Tucson Orthopaedic Institute - North Wyatt Drive — Tucson

Florida

  • Westside Center for Clinical Research — Jacksonville
  • Care Access - St. Petersburg — St. Petersburg
  • Conquest Research — Winter Park

Massachusetts

  • Skylight Health Research - Burlington — Burlington
  • Care Access - Quincy — Quincy

New York

  • Ellipsis Research Group - Brooklyn - 7th Street — Brooklyn
  • Rochester Clinical Research - Buffalo — Buffalo

Alabama

  • AMR Clinical — Mobile

Georgia

  • Orita Clinical Research — Decatur

Illinois

  • Great Lakes Clinical Trials - Ravenswood — Chicago

Trial Details

FieldValue
Enrollment Target 900 participants
Start Date 2026-02-09
Est. Completion 2028-05
Phase Phase 3

Sponsor

Eli Lilly and Company

704 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT07353931

The ClinicalTrials.gov registry entry for NCT07353931 describes a study currently listed as recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 900 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Eli Lilly and Company, which has 704 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 2 conditions, with Osteoarthritis appearing as the primary indexed condition, and to 2 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT07353931 reports 20 study locations spanning 11 distinct geographic areas — top geographies include California, Arizona, Florida. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT07353931 about?

NCT07353931 is a clinical study titled "Efficacy and Safety of Eloralintide (LY3841136) in Participants With Osteoarthritis Knee Pain and Obesity or Overweight". The YDAN master protocol will support two independent studies, J3R-MC-YOA1 and J3R-MC-YOA2. Each study will investigate how well and safely Eloralintide (LY3841136) works in adults with obesity or overweight who have osteoarthritis (OA) of the knee with pain. Participation in the study will last abo...

What is the current status of trial NCT07353931?

This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 900 participants. The study started on 2026-02-09. Estimated completion is 2028-05.

What conditions does trial NCT07353931 study?

This clinical trial studies the following conditions: Osteoarthritis, Overweight or Obesity. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT07353931?

The interventions under investigation include: Placebo (DRUG), Eloralintide (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT07353931?

This trial is sponsored by Eli Lilly and Company, which has 704 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT07353931 being conducted?

This trial has 20 study locations across Alabama, Arizona, California, Florida, Georgia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial