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NCT06623669 · ClinicalTrials.gov registry record · Phase 2
A Mobile Intervention to Reduce Pain and Improve Health-III
A Phase 2 study of Chronic Pain and Osteoarthritis, sponsored by Wake Forest University.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 200
- Enrollment target
- 1
- Study location
NCT06623669 is a Phase 2 study of Chronic Pain and Osteoarthritis that is actively recruiting participants, run by Wake Forest University. The registered enrollment target is 200 participants, below the 772-participant average among 301 other Chronic Pain trials with a reported enrollment target (74% lower). The trial reports 1 study location across 1 state.
The verdict
NCT06623669, a Phase 2 study of Chronic Pain and Osteoarthritis, is actively recruiting participants, sponsored by Wake Forest University.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 200 participants
- Enrollment target
- 1
- Study location
Study Summary
The experience of chronic pain powerfully and negatively affects quality of life and functional independence in aging. Unfortunately, while as many as three in four older adults experience chronic pain, few have access to effective non-pharmacological pain management strategies. Participating in regular physical activity, avoiding sustained sitting, and maintaining a healthy weight are important and interrelated lifestyle inputs to chronic pain, and socially rich behavioral interventions informed by contemporary theories of behavior change appear important for engaging in activity and healthy eating in the long term. Our group has demonstrated in a series of Stage I trials that a group-mediated behavioral intervention combining dietary behavior change and a physical activity program focused on moving often throughout the day contributes to meaningful weight loss, and lasting weight maintenance, with pilot data suggesting this may contribute to improved pain, physical function, and health-related quality of life among older adults with chronic pain. As these were NIH Stage I trials, there are several important gaps to be addressed in the present trial: (1) both studies of chronic pain recruited small samples and were 12 weeks in duration, limiting our ability to establish efficacy and the durability of changes to activity, HRQOL, and pain outcomes; (2) participants included anyone with chronic pain, regardless of pain type, a likely contributor to heterogeneous pain intensity and interference findings; and (3) the investigators have yet to examine behavioral maintenance. The overarching goal of the proposed Stage II "mobile intervention to reduce pain and improve health-III (MORPH-III)" is to establish the efficacy of the intervention for enhancing physical activity via steps (primary), and for reducing pain interference and body weight while enhancing physical function (secondary) among older adults with chronic knee or hip osteoarthritic (OA) pain. The investigato
Conditions Studied
Interventions
- BEHAVIORAL MORPH
- BEHAVIORAL Measurement Only
Study Locations (1)
North Carolina
- Wake Forest University - Winston-Salem
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 200 participants |
| Start Date | 2025-08-14 |
| Est. Completion | 2029-08-31 |
| Phase | Phase 2 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06623669
The ClinicalTrials.gov registry entry for NCT06623669 describes a study currently listed as recruiting, categorized as Phase 2. The registered enrollment target is 200 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 772-participant average among 301 other Chronic Pain trials with a reported enrollment target (74% lower). The listed sponsor is Wake Forest University, which has 100 total studies on file at ClinicalTrials.gov.
The record links to 4 conditions, with Chronic Pain appearing as the primary indexed condition, and to 2 interventions - of which MORPH is the first listed.
NCT06623669 reports 1 study location spanning 1 distinct geographic area - top geographies include North Carolina.
Frequently Asked Questions
What is clinical trial NCT06623669 about?
NCT06623669 is a clinical study titled "A Mobile Intervention to Reduce Pain and Improve Health-III". The experience of chronic pain powerfully and negatively affects quality of life and functional independence in aging. Unfortunately, while as many as three in four older adults experience chronic pain, few have access to effective non-pharmacological pain management strategies. Participating in reg...
What is the current status of trial NCT06623669?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 200 participants. The study started on 2025-08-14. Estimated completion is 2029-08-31.
What conditions does trial NCT06623669 study?
This clinical trial studies the following conditions: Chronic Pain, Osteoarthritis, Obesity and Overweight, Inactivity.
What interventions are being tested in trial NCT06623669?
The interventions under investigation include: MORPH (BEHAVIORAL), Measurement Only (BEHAVIORAL).
Who is sponsoring clinical trial NCT06623669?
This trial is sponsored by Wake Forest University, which has 100 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06623669 being conducted?
This trial has 1 study location across North Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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