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NCT06451120 · ClinicalTrials.gov registry record · Phase 2
Platelet Rich Plasma Injections In Young And Old Human Subjects
A Phase 2 study of Osteoarthritis and Musculoskeletal Disorders, sponsored by University of California, San Francisco.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 60
- Enrollment target
- 1
- Study location
NCT06451120 is a Phase 2 study of Osteoarthritis and Musculoskeletal Disorders that is actively recruiting participants, run by University of California, San Francisco. The registered enrollment target is 60 participants, below the 817-participant average among 135 other Osteoarthritis trials with a reported enrollment target (93% lower). The trial reports 1 study location across 1 state.
The verdict
NCT06451120, a Phase 2 study of Osteoarthritis and Musculoskeletal Disorders, is actively recruiting participants, sponsored by University of California, San Francisco.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 60 participants
- Enrollment target
- 1
- Study location
Study Summary
This is a randomized, double-blind, placebo-controlled phase 2 study with a secondary crossover phase at the end of the initial trial to ensure all subjects receive one PRP injection. The goal is to identify what proteins change in the blood following repeated intraarticular knee PRP injections in patients with knee osteoarthritis. The objective is to determine the protein changes resulting from a single autologous PRP injection (5 mL) in comparison to a normal saline control. About 60 subjects will take part in this study by two age groups at UCSF into the following arms: Arm A: PRP injection; Arm B: normal saline injection control. The study aims to demonstrate what benefits PRP has on knee osteoarthritis and methods to best achieve biologic effects. Subjects with a diagnosis of knee osteoarthritis ages 18-45 and 46-70 years old presenting to a University Based sports medicine clinic will be screened for potential eligibility. Subjects who meet all qualifying requirements will be recruited from UCSF's orthopedic and primary care clinics. Subjects will be on study for up to 26 weeks Screening: up to 14 days Treatment: injection of PRP or normal saline; subjects can cross over at week 12 to a PRP if originally in the control injection group Follow-up: 2 weeks post-baseline injection, 12 weeks postbaseline, (14 weeks if crossover patient), 26 weeks.
Conditions Studied
Interventions
- DRUG Platelet-Rich Plasma (PRP) Injections
- DEVICE Centrifuge
- DRUG Control saline injection
Study Locations (1)
California
- University of California - San Francisco
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 60 participants |
| Start Date | 2024-06-01 |
| Est. Completion | 2027-02-16 |
| Phase | Phase 2 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06451120
The ClinicalTrials.gov registry entry for NCT06451120 describes a study currently listed as recruiting, categorized as Phase 2. The registered enrollment target is 60 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 817-participant average among 135 other Osteoarthritis trials with a reported enrollment target (93% lower). The listed sponsor is University of California, San Francisco, which has 1,713 total studies on file at ClinicalTrials.gov.
The record links to 3 conditions, with Osteoarthritis appearing as the primary indexed condition, and to 3 interventions - of which Platelet-Rich Plasma (PRP) Injections is the first listed.
NCT06451120 reports 1 study location spanning 1 distinct geographic area - top geographies include California.
Frequently Asked Questions
What is clinical trial NCT06451120 about?
NCT06451120 is a clinical study titled "Platelet Rich Plasma Injections In Young And Old Human Subjects". This is a randomized, double-blind, placebo-controlled phase 2 study with a secondary crossover phase at the end of the initial trial to ensure all subjects receive one PRP injection. The goal is to identify what proteins change in the blood following repeated intraarticular knee PRP injections in p...
What is the current status of trial NCT06451120?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 60 participants. The study started on 2024-06-01. Estimated completion is 2027-02-16.
What conditions does trial NCT06451120 study?
This clinical trial studies the following conditions: Osteoarthritis, Musculoskeletal Disorders, Articular Cartilage.
What interventions are being tested in trial NCT06451120?
The interventions under investigation include: Platelet-Rich Plasma (PRP) Injections (DRUG), Centrifuge (DEVICE), Control saline injection (DRUG).
Who is sponsoring clinical trial NCT06451120?
This trial is sponsored by University of California, San Francisco, which has 1,713 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06451120 being conducted?
This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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