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NCT04895306 · ClinicalTrials.gov registry record · Phase 2
Testosterone Replacement to Alleviate Pain in Postmenopausal Women (TRAPP Trial)
A Phase 2 study of Pain and Opioid Use, sponsored by Brigham and Women's Hospital.
- Active
- Registry status
- Phase 2
- Development phase
- 40
- Enrollment target
- 1
- Study location
NCT04895306: Active Phase 2 study of Pain and Opioid Use, sponsored by Brigham and Women's Hospital.
NCT04895306 is a Phase 2 study of Pain and Opioid Use that is active but no longer recruiting, run by Brigham and Women's Hospital. The registered enrollment target is 40 participants, below the 304-participant average among 374 other Pain trials with a reported enrollment target (87% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04895306, a Phase 2 study of Pain and Opioid Use, is active but no longer recruiting, sponsored by Brigham and Women's Hospital.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 2
- Development phase
- 40 participants
- Enrollment target
- 1
- Study location
Study Summary
The aim of this trial is to evaluate whether testosterone replacement results in greater improvement in pain perception, pain tolerance, sexual function, physical function and quality of life when compared with placebo in women with chronic back pain treated with opioids who have low testosterone.
Primary Outcome
The Pain Interference Subscale of the BPI is specifically relevant to patients with chronic back pain who are using opioids and correlates strongly with the patient's quality of life.
Conditions Studied
Interventions
- DRUG Placebo
- DRUG Testosterone Cypionate
Study Locations (1)
Massachusetts
- Brigham and Women's Hospital - Boston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 40 participants |
| Start Date | 2022-11-15 |
| Est. Completion | 2026-06-30 |
| Phase | Phase 2 |
What the registry record for NCT04895306 still lists
NCT04895306 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 40 participants, a relatively small participant target, below the 304-participant average among 374 other Pain trials with a reported enrollment target (87% lower).
The record links to 4 conditions, with Pain appearing as the primary indexed condition, and to 2 interventions - of which Placebo is the first listed.
NCT04895306 reports a single indexed study location in Massachusetts.
Frequently Asked Questions
What is clinical trial NCT04895306 about?
NCT04895306 is a clinical study titled "Testosterone Replacement to Alleviate Pain in Postmenopausal Women (TRAPP Trial)". The aim of this trial is to evaluate whether testosterone replacement results in greater improvement in pain perception, pain tolerance, sexual function, physical function and quality of life when compared with placebo in women with chronic back pain treated with opioids who have low testosterone.
What is the current status of trial NCT04895306?
This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 40 participants. The study started on 2022-11-15. Estimated completion is 2026-06-30.
What conditions does trial NCT04895306 study?
This clinical trial studies the following conditions: Pain, Opioid Use, Back Pain, Androgen Deficiency.
What interventions are being tested in trial NCT04895306?
The interventions under investigation include: Placebo (DRUG), Testosterone Cypionate (DRUG).
Who is sponsoring clinical trial NCT04895306?
This trial is sponsored by Brigham and Women's Hospital, which has 937 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04895306 being conducted?
This trial has 1 study location across Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Pain
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04895306's enrollment target sits among peer trials
40 282nd of 374 higher than 85 of 374 other Pain trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Pain trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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