Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

RECRUITING Phase 2

A Study of Brenipatide in Participants With Opioid Use Disorder

NCT07420283 · View on ClinicalTrials.gov ↗

Study Summary

The purpose of this study is to see if brenipatide, when compared to placebo, is safe and effective for participants with opioid use disorder, when used with buprenorphine with or without naloxone. The maximum potential duration of study participation for a participant in Part A is approximately 144 weeks, maximum potential duration of study participation for a participant in Part B is approximately 116 weeks. The actual duration will vary for each participant depending on the time of enrollment and the overall rate of study enrollment.

Conditions Studied

Interventions

  • DRUG Placebo
  • DRUG Buprenorphine
  • DRUG Brenipatide

Study Locations (20)

Florida

  • Bradenton Research Center, Inc. — Bradenton
  • K2 Medical Research - Daytona Beach — Daytona Beach
  • NextPhase Research Florida - Hollywood — Hollywood
  • Accel Research Sites - Lakeland Clinical Research Unit — Lakeland
  • Life Arc Research Centers - Miami — Miami
  • Advanced Research for Health Improvement, LLC — Naples
  • Innovative Research Institute - Port Charlotte — Port Charlotte
  • Better Years Ahead Medical Center — Tampa
  • Neuroscience Research Institute - West Palm Beach — West Palm Beach

California

  • Ark Clinical Research - Fountain Valley — Fountain Valley
  • Center on Substance Use and Health (CSUH) — San Francisco
  • UCSF Weill Institute for Neurosciences - Substance Use Disorders Clinic - Mission Bay — San Francisco

Alabama

  • Parkway Medical Center — Birmingham

Arizona

  • NoesisPharma - Phoenix - East Shea Boulevard — Phoenix

Arkansas

  • Woodland International Research Group — Little Rock

Illinois

  • Re:Cognition Health - Chicago — Chicago

Indiana

  • Indiana University Health Neuroscience Center — Indianapolis

Kentucky

  • University of Kentucky Chandler Medical Center — Lexington

Trial Details

FieldValue
Enrollment Target 465 participants
Start Date 2026-02-13
Est. Completion 2028-02
Phase Phase 2

Sponsor

Eli Lilly and Company

704 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT07420283

The ClinicalTrials.gov registry entry for NCT07420283 describes a study currently listed as recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 465 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Eli Lilly and Company, which has 704 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Opioid Use Disorder appearing as the primary indexed condition, and to 3 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT07420283 reports 20 study locations spanning 10 distinct geographic areas — top geographies include Florida, California, Alabama. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT07420283 about?

NCT07420283 is a clinical study titled "A Study of Brenipatide in Participants With Opioid Use Disorder". The purpose of this study is to see if brenipatide, when compared to placebo, is safe and effective for participants with opioid use disorder, when used with buprenorphine with or without naloxone. The maximum potential duration of study participation for a participant in Part A is approximately 14...

What is the current status of trial NCT07420283?

This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 465 participants. The study started on 2026-02-13. Estimated completion is 2028-02.

What conditions does trial NCT07420283 study?

This clinical trial studies the following conditions: Opioid Use Disorder. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT07420283?

The interventions under investigation include: Placebo (DRUG), Buprenorphine (DRUG), Brenipatide (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT07420283?

This trial is sponsored by Eli Lilly and Company, which has 704 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT07420283 being conducted?

This trial has 20 study locations across Alabama, Arizona, Arkansas, California, Florida. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial