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Obesity: early-phase trial registry
306 of 1,057 indexed Obesity trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #3 of 28,707 conditions by registered trial count.
1,057 US clinical trials · 306 currently recruiting · #3 of 28,707 conditions by registered trial count
Obesity: 1,057 US clinical trials tracked, 306 recruiting.
Obesity is the subject of 1,057 registered US clinical trials on ClinicalTrials.gov, 306 of them currently open to new participants. 107 are in Phase 3-4 (later-stage) and 196 in Phase 1-2 (earlier-stage). The most active sponsor is Eli Lilly and Company, running 48 of these trials.
Enrollment posture brief
Registry condition obesity
OPEN 306 | RECR 29% | LATE 107 | EARLY 196 | RANK #3 | SPON 48
Volume-matched condition peers
Nearest open-share peer: Metastatic Pancreatic Adenocarcinoma (29% recruiting · 38 trials)
Obesity lists 306 open slots (29% of 1,057 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Obesity on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Obesity is recruiting below its size-band peers.
306 of 1,057 indexed trials (28.9%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Obesity trials is spread across many organizations.
Eli Lilly and Company accounts for 48 of 1,057 trials (4.5%). 314 distinct sponsors appear on at least one study for this condition label.
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Typical Obesity enrolment sits around 90 participants.
Median target enrolment is 90 among the 1,054 trials that report a genuine target (sentinel values excluded). 555 of those (52.7%) plan for fewer than 100 participants.
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Obesity research is mostly interventional.
894 interventional and 163 observational studies make up this index (84.6% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
1,057 total, page 9 of 22
Sex Disparities in Hypoxic Sympatholysis and Impact of Obesity
University of Missouri-Columbia
NCT04436731
Role of Pharmacotherapy in Counteracting Weight Regain in Adolescents With Severe Obesity
University of Minnesota
NCT04298203
Using Technology to Investigate Lapses in a Weight Loss Program Among Individuals With Overweight and Obesity
Williams College
NCT06023537
Differences in Nutrient Use During Exercise Between Children of Varying Body Mass Indices and Fitness Levels
Arkansas Children's Hospital Research Institute
NCT04819308
The Renin-Angiotensin-Aldosterone System in Adiposity, Blood Pressure and Glucose in African Americans
Ohio State University
NCT03938389
Dietary, Physiological, Genetic, and Behavioral Predictors of Health in a Young, Ethnically-Mixed Population
Pennington Biomedical Research Center
NCT00945633
Reprometabolic Syndrome Mediates Subfertility in Obesity
University of Colorado, Denver
NCT02653092
A Dose-Range Study of Aleniglipron (GSBR-1290) in Participants Living With Obesity or Overweight With at Least One Weight-related Comorbidity
Gasherbrum Bio, Inc., a wholly owned subsidiary of Structure Therapeutics
NCT06703021
Effect of Maridebart Cafraglutide on the Heart's Electrical Activity
Amgen
NCT07229157
Study to Explore the Safety and Efficacy of NT-0796 as an Adjunct to Semaglutide in Participants With Obesity (RESOLVE-2)
NodThera Limited
NCT07220629
SCALE KIDS: Research Study to Look at How Well a New Medicine is at Lowering Weight in Children With Obesity
Novo Nordisk A/S
NCT04775082
Comparing Reduction With ESD- Versus APC-TORe
Stephen Firkins
NCT06131281
Efficacy, Safety and Tolerability of AZD6234 in Participants Living With Overweight or Obesity With Type 2 Diabetes Who Are on a Stable Dose of GLP-1 Receptor Agonist
AstraZeneca
NCT06851858
The TRIABETES - ARMMS-T2D Study: A Randomized Trial to Compare Surgical and Medical Treatments for Type 2 Diabetes
University of Pittsburgh
NCT01047735
Piloting a Patient Navigator Program for Weight Loss
Drexel University
NCT06972381
A Research Study on How NNC0638-0355, a New Medicine, Works in People Living With Overweight or Obesity
Novo Nordisk A/S
NCT06577766
Dietary Fiber: Is it the Missing Link in Achieving Long Term Behavior Change?
Oklahoma State University
NCT06227494
Foods Within a Meal and Food Liking Study
The University of Tennessee, Knoxville
NCT03783507
Effect of Time-restricted Eating on Catecholamine-sensitivity of Adipose Tissue in Obese Adults
University of California, San Diego
NCT04916730
Fiber-rich Foods to Treat Obesity and Prevent Colon Cancer
Emory University
NCT04780477
Risk of Metabolic Adaptation After Weight Loss
Medical College of Wisconsin
NCT05139420
Lowering Caloric Density of the Diet
The University of Tennessee, Knoxville
NCT02674971
Tocotrienols for Obesity of Postmenopausal Women
Texas Tech University Health Sciences Center
NCT03705845
Does Personality Predict Patient Adherence, Health Behaviors, and Weight Loss Outcomes During the Latino Crossover Semaglutide Study (LCSS)? (Story-LCSS Project)
Loma Linda University
NCT05622045
Identification of Novel Skeletal Muscle-derived Factors That Promote Lipid Oxidation (Columbus)
AdventHealth Translational Research Institute
NCT01911091
A Study of Adipose Tissue in Adaptive Responses to Exercise
Mayo Clinic
NCT06053125
Diabetes Prevention Program With or Without Hunger Training in Helping to Lower Breast Cancer Risk in Obese Participants
M.D. Anderson Cancer Center
NCT03546972
The Medically Reproducing Bariatric Surgery (MRB) II Study
Durham VA Medical Center
NCT06363747
Study of Subcutaneously Administered ENT-03 for the Treatment of Obesity and Diabetes
Metabolics Pharma
NCT05925920
Hybrid Argon Plasma Coagulation and Endoscopic Sleeve Gastroplasty Validation Study
True You Weight Loss
NCT05870943
Intestinal Metabolic Reprogramming as a Key Mechanism of Gastric Bypass in Humans
University of Pittsburgh
NCT02710370
Tirzepatide for Obesity and Meth Use Disorder
University of Texas Southwestern Medical Center
NCT06745128
The Effect of Three Different Dietary Messages on Dietary Intake and Health in Families
The University of Tennessee, Knoxville
NCT01510678
TARGETing Healthy Weight Loss in the Context of Food Insecurity
Pennington Biomedical Research Center
NCT05601804
Role of Dietary Habits in Efficacy of Bariatric Surgery - Study C
Brigham and Women's Hospital
NCT03482986
Revisiting A Mobile Intervention to Reduce Pain and Improve Health
Wake Forest University
NCT04655001
Role of Dietary Habits in Efficacy of Bariatric Surgery - Study B
Brigham and Women's Hospital
NCT03467906
Lorcaserin in Obesity: Identification of CNS Targets Using FMRI
Beth Israel Deaconess Medical Center
NCT02400359
GLP-1s to Enhance Lasting Optimal Weight
Wake Forest University Health Sciences
NCT06861439
Monounsaturated Fatty Acid Supplementation for Overweight and Obese Individuals With Prediabetes
Brigham and Women's Hospital
NCT05560971
The Effect of Tirzepatide on Menopausal Vasomotor Symptoms and Biological Aging in Post-menopausal Women With Obesity
Mayo Clinic
NCT07218445
Determine How Consumption of Dairy Fat Fractions Rich in Phospholipids and Proteins Influence Inflammation in the Fed State-Phase 1
University of California, Davis
NCT01811329
Activity Level Monitoring Study
Ohio State University
NCT05379088
Food is Medicine vs Lifestyle Medicine For Cardiovascular Kidney Metabolic (CKM) Syndrome
Rutgers, The State University of New Jersey
NCT06461273
Breast Cancer Survivors RESET (Reducing Weight and Elevated Stress Levels Using Educational and Behavioral Tools): A Pilot, Feasibility Study
H. Lee Moffitt Cancer Center and Research Institute
NCT07101861
Role of Sympathetic Vasoconstriction on Insulin-Mediated Microvascular Recruitment and Glucose Uptake in Obesity
Vanderbilt University Medical Center
NCT03318094
Collection of Human Tissue Samples From the Neck Region for Characterization of Its Molecular and Biochemical Signatures
AdventHealth Translational Research Institute
NCT02274805
Effect of Prolonged (72 Hour) Glucagon Administration on Energy Expenditure in Healthy Obese Subjects
AdventHealth Translational Research Institute
NCT03139305
Postprandial Nutrient Homeostasis Before and After Weight Loss Induced by Low-calorie Diet or RYGB
Washington University School of Medicine
NCT03091725
Healthy Eating Patterns During a Lifestyle Intervention
The University of Tennessee, Knoxville
NCT01682317
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 95 |
| Phase 2 | 101 |
| Phase 3 | 69 |
| Phase 4 | 38 |
Top Sponsors
Named interventions
Most-linked intervention names on Obesity records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Obesity trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Obesity page
1,057 registered trials, 306 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 306 Obesity trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Eli Lilly and Company sponsors the most Obesity trials on record, review their full trial history before evaluating a specific study. See Eli Lilly and Company's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Obesity condition card totals 1,057 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.