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NCT03091725 · ClinicalTrials.gov registry record · NA
Postprandial Nutrient Homeostasis Before and After Weight Loss Induced by Low-calorie Diet or RYGB
A NA study of Obesity, sponsored by Washington University School of Medicine.
- Active
- Registry status
- NA
- Development phase
- 30
- Enrollment target
- 1
- Study location
NCT03091725: Active NA study of Obesity, sponsored by Washington University School of Medicine.
NCT03091725 is a NA study of Obesity that is active but no longer recruiting, run by Washington University School of Medicine. The registered enrollment target is 30 participants, below the 819-participant average among 1,053 other Obesity trials with a reported enrollment target (96% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03091725, a NA study of Obesity, is active but no longer recruiting, sponsored by Washington University School of Medicine.
- ACTIVE NOT RECRUITING
- Registry status
- NA
- Development phase
- 30 participants
- Enrollment target
- 1
- Study location
Study Summary
The purpose of this study is to compare the metabolic responses to low-carbohydrate and standard-carbohydrate meals in African Americans and non-Hispanic White adults with obesity and the effect of weight loss induced by low-calorie diet (LCD) or Roux-en-Y gastric bypass (RYGB) on the metabolic responses to low-carbohydrate and standard meals. Participants will consume: 1) a standard-carbohydrate meal (\~49 g glucose) and 2) a low-carbohydrate (\~3.4 g glucose) meal on separate study visits performed in a randomized order. We will evaluate the meals' effect before and after \~16-18% weight loss on postprandial i) insulin kinetics, ii) glucose kinetics iii) β-cell function; iv) plasma triglyceride and non-esterified fatty acid concentrations; v) plasma hormone concentrations; vi) plasma cytokine concentrations; vi) plasma metabolomics; and vii) adipose tissue transcriptomics.
Primary Outcome
Plasma insulin kinetics will be assessed in blood samples collected before and after consuming a standard-carbohydrate or a low-carbohydrate meal.
Conditions Studied
Interventions
- PROCEDURE Roux-en-Y gastric bypass surgery
- BEHAVIORAL Low-calorie diet
Study Locations (1)
Missouri
- Beth Henk - St Louis
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 30 participants |
| Start Date | 2017-04-25 |
| Est. Completion | 2026-12 |
| Phase | NA |
What the registry record for NCT03091725 still lists
NCT03091725 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 30 participants, a relatively small participant target, below the 819-participant average among 1,053 other Obesity trials with a reported enrollment target (96% lower).
The record links to 1 condition, with Obesity appearing as the primary indexed condition, and to 2 interventions - of which Roux-en-Y gastric bypass surgery is the first listed.
NCT03091725 reports a single indexed study location in Missouri.
Frequently Asked Questions
What is clinical trial NCT03091725 about?
NCT03091725 is a clinical study titled "Postprandial Nutrient Homeostasis Before and After Weight Loss Induced by Low-calorie Diet or RYGB". The purpose of this study is to compare the metabolic responses to low-carbohydrate and standard-carbohydrate meals in African Americans and non-Hispanic White adults with obesity and the effect of weight loss induced by low-calorie diet (LCD) or Roux-en-Y gastric bypass (RYGB) on the metabolic resp...
What is the current status of trial NCT03091725?
This trial is currently active not recruiting. It is a NA study. The enrollment target is 30 participants. The study started on 2017-04-25. Estimated completion is 2026-12.
What conditions does trial NCT03091725 study?
This clinical trial studies the following conditions: Obesity.
What interventions are being tested in trial NCT03091725?
The interventions under investigation include: Roux-en-Y gastric bypass surgery (PROCEDURE), Low-calorie diet (BEHAVIORAL).
Who is sponsoring clinical trial NCT03091725?
This trial is sponsored by Washington University School of Medicine, which has 1,502 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT03091725 being conducted?
This trial has 1 study location across Missouri. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Obesity
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT03091725's enrollment target sits among peer trials
30 851st of 1053 higher than 173 of 1,053 other Obesity trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Obesity trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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