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NCT04436731 · ClinicalTrials.gov registry record · Early Phase 1

Sex Disparities in Hypoxic Sympatholysis and Impact of Obesity

A Early Phase 1 study of Healthy and Obesity, sponsored by University of Missouri-Columbia.

Active
Registry status
Early Phase 1
Development phase
104
Enrollment target
1
Study location

NCT04436731: Active Early Phase 1 study of Healthy and Obesity, sponsored by University of Missouri-Columbia.

NCT04436731 is a Early Phase 1 study of Healthy and Obesity that is active but no longer recruiting, run by University of Missouri-Columbia. The registered enrollment target is 104 participants, below the 647-participant average among 1,090 other Healthy trials with a reported enrollment target (84% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.

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The verdict

NCT04436731, a Early Phase 1 study of Healthy and Obesity, is active but no longer recruiting, sponsored by University of Missouri-Columbia.

ACTIVE NOT RECRUITING
Registry status
Early Phase 1
Development phase
104 participants
Enrollment target
1
Study location

Study Summary

Patients with sleep apnea are at increased risk of developing cardiovascular disease - with women at potentially greater risk than men. Contributing mechanisms are not well understood, but may be related to how women respond to low oxygen and, given over 70% of patients with sleep apnea are obese, the impact of obesity. This project seeks to increase our understanding of mechanisms that may contribute to sex differences in the cardiovascular response to low oxygen with the hope that this knowledge will improve the efficacy of current therapies and support the discovery of novel therapeutics.

Primary Outcome

Vascular conductance is an index of vascular tone and is measured using a technique called venous occlusion plethysmography.

Conditions Studied

Healthy Obesity Vasodilation Vasoconstriction

Interventions

  • DRUG Norepinephrine
  • DRUG Dexmedetomidine
  • DRUG Phenylephrine
  • DRUG Phentolamine
  • OTHER Hypoxia Exposure

Study Locations (1)

Missouri

  • University of Missouri-Columbia - Columbia

Trial Details

FieldValue
Enrollment Target 104 participants
Start Date 2020-12-09
Est. Completion 2026-06-30
Phase Early Phase 1
University of Missouri-Columbia

291 total trials

What the registry record for NCT04436731 still lists

NCT04436731 is an interventional study that assigns participants to a tested intervention. The registered 104 participants enrollment target is mid-sized for trials with a published cap, below the 647-participant average among 1,090 other Healthy trials with a reported enrollment target (84% lower).

The record links to 4 conditions, with Healthy appearing as the primary indexed condition, and to 5 interventions - of which Norepinephrine is the first listed.

NCT04436731 reports a single indexed study location in Missouri.

Frequently Asked Questions

What is clinical trial NCT04436731 about?

NCT04436731 is a clinical study titled "Sex Disparities in Hypoxic Sympatholysis and Impact of Obesity". Patients with sleep apnea are at increased risk of developing cardiovascular disease - with women at potentially greater risk than men. Contributing mechanisms are not well understood, but may be related to how women respond to low oxygen and, given over 70% of patients with sleep apnea are obese, t...

What is the current status of trial NCT04436731?

This trial is currently active not recruiting. It is a Early Phase 1 study. The enrollment target is 104 participants. The study started on 2020-12-09. Estimated completion is 2026-06-30.

What conditions does trial NCT04436731 study?

This clinical trial studies the following conditions: Healthy, Obesity, Vasodilation, Vasoconstriction.

What interventions are being tested in trial NCT04436731?

The interventions under investigation include: Norepinephrine (DRUG), Dexmedetomidine (DRUG), Phenylephrine (DRUG), Phentolamine (DRUG), Hypoxia Exposure (OTHER).

Who is sponsoring clinical trial NCT04436731?

This trial is sponsored by University of Missouri-Columbia, which has 291 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT04436731 being conducted?

This trial has 1 study location across Missouri. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Learn More About Clinical Trials

Similar trials for Healthy

Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.

Where NCT04436731's enrollment target sits among peer trials

104 213th of 1090 higher than 877 of 1,090 other Healthy trials

participants (enrollment target), bucketed by value

Each bar is a band; taller bars hold more other Healthy trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.

Source ClinicalTrials.gov registry export · 2026-08-08

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Related registry views

Source: ClinicalTrials.gov NCT04436731, the US trial registry maintained by the National Library of Medicine. NCT04436731 (mid enrollment · single site footprint · active not recruiting) retrieved and formatted by PlainTrial, see methodology.