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NCT02710370 · ClinicalTrials.gov registry record
Intestinal Metabolic Reprogramming as a Key Mechanism of Gastric Bypass in Humans
A clinical trial of Obesity and Diabetes Mellitus, Type 2, sponsored by University of Pittsburgh.
- Active
- Registry status
- 46
- Enrollment target
- 1
- Study location
NCT02710370: Active study of Obesity and Diabetes Mellitus, Type 2, sponsored by University of Pittsburgh.
NCT02710370 is a study of Obesity and Diabetes Mellitus, Type 2 that is active but no longer recruiting, run by University of Pittsburgh. The registered enrollment target is 46 participants, below the 819-participant average among 1,053 other Obesity trials with a reported enrollment target (94% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02710370, a study of Obesity and Diabetes Mellitus, Type 2, is active but no longer recruiting, sponsored by University of Pittsburgh.
- ACTIVE NOT RECRUITING
- Registry status
- 46 participants
- Enrollment target
- 1
- Study location
Study Summary
The purpose of this research study is to determine how gastric bypass surgery effects metabolism in obesity and Type 2 Diabetes. One mechanism that has been investigated in animal models is change to the biology of the small intestine (Roux limb) and how glucose and other fuels are metabolized (or how the body digests and uses sugar and other fuels). This study will evaluate the role of the intestine in the beneficial metabolic effects of gastric bypass surgery. It specifically will examine whether the intestine increases its metabolism and its activity, and whether this results in an increase in fuel utilization. Thirty two (32) subjects will be recruited (18 with and 14 without Type 2 Diabetes). At the time of gastric bypass surgery, a small piece of intestine that is usually discarded will be collected. At three time points over the first year after surgery, intestinal samples will be obtained by endoscopy or insertion of a lighted flexible tube through the mouth. Blood samples will be taken at all time points, as well. All samples will undergo comprehensive metabolic analyses. Comparisons will be made between the two groups to understand the metabolic changes over time and if there are differences between the two groups.
Primary Outcome
Histology and electron microscopy will be used to assess cellular architecture, brush border, cytoskeleton and junctions, and the size and shape of organelles.
Conditions Studied
Study Locations (1)
Pennsylvania
- Magee-Womens Hospital of UPMC - Pittsburgh
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 46 participants |
| Start Date | 2016-02 |
| Est. Completion | 2028-08-31 |
What the registry record for NCT02710370 still lists
NCT02710370 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 46 participants, a relatively small participant target, below the 819-participant average among 1,053 other Obesity trials with a reported enrollment target (94% lower).
The record links to 5 conditions, with Obesity appearing as the primary indexed condition, and to 0 interventions.
NCT02710370 reports a single indexed study location in Pennsylvania.
Frequently Asked Questions
What is clinical trial NCT02710370 about?
NCT02710370 is a clinical study titled "Intestinal Metabolic Reprogramming as a Key Mechanism of Gastric Bypass in Humans". The purpose of this research study is to determine how gastric bypass surgery effects metabolism in obesity and Type 2 Diabetes. One mechanism that has been investigated in animal models is change to the biology of the small intestine (Roux limb) and how glucose and other fuels are metabolized (or h...
What is the current status of trial NCT02710370?
This trial is currently active not recruiting. The enrollment target is 46 participants. The study started on 2016-02. Estimated completion is 2028-08-31.
What conditions does trial NCT02710370 study?
This clinical trial studies the following conditions: Obesity, Diabetes Mellitus, Type 2, Glucose Metabolism Disorders, Metabolic Diseases, Endocrine System Diseases.
Who is sponsoring clinical trial NCT02710370?
This trial is sponsored by University of Pittsburgh, which has 1,238 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT02710370 being conducted?
This trial has 1 study location across Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Obesity
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT02710370's enrollment target sits among peer trials
46 743rd of 1053 higher than 303 of 1,053 other Obesity trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Obesity trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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