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ClinicalTrials.gov 203 recruiting now official registry

Non-Small Cell Lung Cancer clinical trials

203 of 450 indexed Non-Small Cell Lung Cancer trials are currently recruiting.

450 US clinical trials · 203 currently recruiting

Non-Small Cell Lung Cancer is the subject of 450 registered US clinical trials on ClinicalTrials.gov, 203 of them currently open to new participants. 65 are in Phase 3-4 (later-stage) and 324 in Phase 1-2 (earlier-stage). The most active sponsor is AstraZeneca, running 24 of these trials.

The research picture

Non-Small Cell Lung Cancer has 450 registered US clinical trials, 203 of them open to new participants right now, about 45% of the total.

203
recruiting participants now
45%
of trials open to enrollment
65
in Phase 3–4 (later-stage)
24
top sponsor: AstraZeneca
Phase 1201Phase 2123Phase 362Phase 43

Active & Recent Trials

450 total, page 2 of 9

RECRUITING Phase 1 420 participants

A Study of LY4052031 in Participants With Advanced or Metastatic Urothelial Cancer or Other Solid Tumors

Eli Lilly and Company

NCT06465069

RECRUITING Phase 1 420 participants

A Clinical Trial to Test if an Investigational Combination Therapy With BNT326 and BNT327 is Safe and Potentially Beneficial for People With Advanced Non-small Cell Lung Cancer (NSCLC)

BioNTech SE

NCT07111520

RECRUITING Phase 1 403 participants

A Study Evaluating FMC-376 in Participants With KRAS G12C Mutated Solid Tumors

Frontier Medicines Corporation

NCT06244771

RECRUITING Phase 3 400 participants

Beamion LUNG-3: A Study to Test Whether Zongertinib Helps People With Surgically Removed, Non-small Cell Lung Cancer With HER2 Mutations Compared With Standard Treatment

Boehringer Ingelheim

NCT07195695

RECRUITING 400 participants

BostonGene and Exigent Genomic INsight Study

BostonGene

NCT06272864

RECRUITING Phase 1 387 participants

BBO-11818 in Adult Subjects With KRAS Mutant Cancer

TheRas, Inc., d/b/a BBOT (BridgeBio Oncology Therapeutics)

NCT06917079

RECRUITING Phase 1 365 participants

A Study of GV20-0251 Monotherapy and GV20-0251 in Combination With Pembrolizumab in Participants With Solid Tumor Malignancies

GV20 Therapeutics

NCT05669430

RECRUITING Phase 1 364 participants

Study of STK-012 Alone and With Other Treatments in Patients With Advanced Lung Cancer and Other Cancers

Synthekine

NCT05098132

RECRUITING Phase 1 364 participants

A Study to Find a Suitable Dose of ASP5834 in Adults With Solid Tumors

Astellas Pharma

NCT07094204

RECRUITING 350 participants

Predicting Responsiveness in Oncology Patients Based on Host Response Evaluation During Anti Cancer Treatments, Using Multiomics

OncoHost

NCT05736029

RECRUITING Phase 1 340 participants

A Study of LY4050784 in Participants With Advanced or Metastatic Solid Tumors

Eli Lilly and Company

NCT06561685

RECRUITING Phase 1 336 participants

Phase 1 Study of MRTX1719 in Solid Tumors With MTAP Deletion

Bristol-Myers Squibb

NCT05245500

RECRUITING Phase 1 320 participants

A Study Evaluating the Safety, Activity, and Pharmacokinetics of Divarasib as a Single Agent or in Combination With Other Anti-Cancer Therapies in Participants With Previously Untreated Advanced or Metastatic Non-Small Cell Lung Cancer With a KRAS G12C Mutation

Hoffmann-La Roche

NCT05789082

RECRUITING 320 participants

Tumor Cell and DNA Detection in the Blood, Urine, and Bone Marrow

University of Missouri-Columbia

NCT03551951

RECRUITING Phase 3 320 participants

Radiotherapy to Block Oligoprogression In Metastatic Non-Small-Cell Lung Cancer

Canadian Cancer Trials Group

NCT06686771

RECRUITING Phase 2 318 participants

Prospective Trial Assessing Real World Outcomes Response to Pembro in Black Patients w/ NSCLC

H. Lee Moffitt Cancer Center and Research Institute

NCT06745882

RECRUITING Phase 1 316 participants

Phase 1a and Phase 2 Study for Safety, Preliminary Efficacy, PK and PD of ST-067

Simcha IL-18

NCT04787042

RECRUITING NA 300 participants

The Effect of Beta-glucan in Non-Small Cell Lung Cancer

University of Louisville

NCT00682032

RECRUITING Phase 1 300 participants

BGB-43395 Alone or as Part of Combination Therapies in Participants With Breast Cancer and Other Advanced Solid Tumors

BeiGene

NCT06120283

RECRUITING Phase 1 295 participants

A Phase 1/2 Study of VS-7375 in Patients With KRAS G12D-Mutated Solid Tumors

Verastem

NCT07020221

RECRUITING Phase 2 285 participants

Administration of Autologous T-Cells Genetically Engineered to Express T-Cell Receptors Reactive Against Neoantigens in People With Metastatic Cancer

National Cancer Institute (NCI)

NCT03412877

RECRUITING Phase 1 280 participants

Clinical Trial Evaluating the Safety, Tolerability and Preliminary Efficacy of BNT116 Alone and in Combinations in Patients With Advanced Non-small Cell Lung Cancer

BioNTech SE

NCT05142189

RECRUITING Phase 2 280 participants

Dose Attenuated Chemotherapy in Compromised Patients With Lung Cancer

Fox Chase Cancer Center

NCT05800587

RECRUITING Phase 2 278 participants

A Study of Novel Combinations in Non-Small Cell Lung Cancer (NSCLC)

AstraZeneca

NCT07098338

RECRUITING Phase 3 272 participants

JoLT-Ca Sublobar Resection (SR) Versus Stereotactic Ablative Radiotherapy (SAbR) for Lung Cancer

University of Texas Southwestern Medical Center

NCT02468024

RECRUITING Phase 1 270 participants

A First-in-human Study of PRTH-101 Monotherapy +/- Pembrolizumab in Subjects With Advanced Malignancies

Incendia Therapeutics

NCT05753722

RECRUITING Phase 1 267 participants

A Study to Learn About the Study Medicine Called PF-07799933 in People With Advanced Solid Tumors With BRAF Alterations.

Pfizer

NCT05355701

RECRUITING Phase 1 251 participants

First-In-Human Study of STX-721/PFL-721 in Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer Harboring EGFR or HER2 Exon 20 Insertion Mutations

Pierre Fabre Medicament

NCT06043817

RECRUITING Phase 1 250 participants

A Study of MGC026 in Participants With Advanced Solid Tumors

MacroGenics

NCT06242470

RECRUITING Phase 1 250 participants

FiH Study to Investigate Safety, PK and Efficacy of the NaPi2b ADC TUB-040 in Patients With PROC or r/r Adenocarcinoma NSCLC

Tubulis

NCT06303505

RECRUITING Phase 1 250 participants

Open-label Study of BBO-8520 in Adult Subjects With KRASG12C Non-small Cell Lung Cancer

TheRas, Inc., d/b/a BBOT (BridgeBio Oncology Therapeutics)

NCT06343402

RECRUITING Phase 2 245 participants

Study of Autologous Tumor Infiltrating Lymphocytes in Patients With Solid Tumors

Iovance Biotherapeutics

NCT03645928

RECRUITING NA 244 participants

Comparing Single vs Multiple Dose Radiation for Cancer Patients With Brain Metastasis and Receiving Immunotherapy

Wake Forest University Health Sciences

NCT05703269

RECRUITING Phase 2 243 participants

A Phase II Clinical Study to Evaluate HLX43 in Subjects With Advanced Non-small Cell Lung Cancer (NSCLC)

Shanghai Henlius Biotech

NCT06907615

RECRUITING Phase 1 242 participants

VMD-928 Monotherapy and in Combination With Pembrolizumab to Treat TrkA Overexpression Driven Solid Tumors or Lymphoma

VM Oncology

NCT03556228

RECRUITING Phase 1 210 participants

Autologous T-cells Genetically Engineered to Express Receptors Reactive Against KRAS Mutations in Conjunction With a Vaccine Directed Against These Antigens in Participants With Metastatic Cancer

National Cancer Institute (NCI)

NCT06253520

RECRUITING 210 participants

Using Urine Samples to Identify Lung Cancer

Memorial Sloan Kettering Cancer Center

NCT06033248

RECRUITING 200 participants

Extracellular Vesicles and Particles (EVP) as Biomarkers of Recurrence in Non-Small Cell Lung Cancer

Memorial Sloan Kettering Cancer Center

NCT05424029

RECRUITING 200 participants

Solid Tumor Analysis for HLA Loss of Heterozygosity (LOH) and Apheresis for CAR T- Cell Manufacturing

A2 Biotherapeutics

NCT04981119

RECRUITING Phase 2 200 participants

A Phase 2 Study of Zanidatamab in Patients With HER2-expressing Tumors

Jazz Pharmaceuticals

NCT06695845

RECRUITING Phase 1 195 participants

A Study of PT0511 in Participants With KRAS Mutated or Amplified Advanced Solid Tumors

PAQ Therapeutics

NCT07300150

RECRUITING Phase 1 191 participants

Safety and Tolerability of TNG456 Alone and in Combination With Abemaciclib in Patients With Solid Tumors With MTAP Loss

Tango Therapeutics

NCT06810544

RECRUITING Phase 1 180 participants

A Phase 1/2 Clinical Trial to Assess the Safety, Tolerability, Pharmacokinetics and Preliminary Efficacy of HMBD-501 in Patients With HER3-Expressing Solid Tumors

Hummingbird Bioscience

NCT06956690

RECRUITING Phase 2 180 participants

Volrustomig Priming Regimens Exploratory Phase II Platform Study

AstraZeneca

NCT06448754

RECRUITING Phase 2 178 participants

A Study of IBI363 in Subjects with Advanced Solid Malignancies

Innovent Biologics (Suzhou) Co.

NCT06281678

RECRUITING Phase 1 174 participants

A Phase I Clinical Study to Evaluate the PK Profile, Efficacy, Safety and Immunogenicity of HLX17 vs. Keytruda® in Multiple Resected Solid Tumors

Shanghai Henlius Biotech

NCT07160335

RECRUITING Phase 1 168 participants

A Study of OR502, a Monoclonal Antibody Targeting LILRB2, Alone and in Combination With Anticancer Agents

OncoResponse

NCT06090266

RECRUITING Phase 1 166 participants

A Phase 1, First-in-human Study of OKN4395 and Pembrolizumab in Patients With Solid Tumors

Epkin

NCT06789172

RECRUITING Phase 1 164 participants

A Study to Assess Safety, Tolerability, and Pharmacokinetics of ABSK112 in Patients With Non-Small Cell Lung Cancer

Abbisko Therapeutics Co

NCT06225804

RECRUITING Phase 1 162 participants

A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Different Anticancer Agents in Advanced Cancers

Pfizer

NCT07227298

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Phase Distribution

PhaseTrial count
Phase 1 201
Phase 2 123
Phase 3 62
Phase 4 3

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Non-Small Cell Lung Cancer Trial Landscape

450 indexed Non-Small Cell Lung Cancer studies · 203 recruiting (45%).

Phase mix: 65 late (III/IV) vs 324 early (I/II).

Top sponsor: AstraZeneca (24 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Non-Small Cell Lung Cancer?

PlainTrial tracks 450 US clinical trials for Non-Small Cell Lung Cancer, of which 203 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Non-Small Cell Lung Cancer?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.