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ClinicalTrials.gov 203 recruiting now official registry

Non-Small Cell Lung Cancer clinical trials

203 of 450 indexed Non-Small Cell Lung Cancer trials are currently recruiting.

450 US clinical trials · 203 currently recruiting

Non-Small Cell Lung Cancer is the subject of 450 registered US clinical trials on ClinicalTrials.gov, 203 of them currently open to new participants. 65 are in Phase 3-4 (later-stage) and 324 in Phase 1-2 (earlier-stage). The most active sponsor is AstraZeneca, running 24 of these trials.

The research picture

Non-Small Cell Lung Cancer has 450 registered US clinical trials, 203 of them open to new participants right now, about 45% of the total.

203
recruiting participants now
45%
of trials open to enrollment
65
in Phase 3–4 (later-stage)
24
top sponsor: AstraZeneca
Phase 1201Phase 2123Phase 362Phase 43

Active & Recent Trials

450 total, page 3 of 9

RECRUITING Phase 1 162 participants

Phase I Study of [177Lu]Lu-NNS309 in Patients With Pancreatic, Lung, Breast and Colorectal Cancers

Novartis Pharmaceuticals

NCT06562192

RECRUITING Phase 1 159 participants

Study of AU-007, A Monoclonal Antibody That Binds to IL-2 and Inhibits IL-2Rα Binding, in Patients With Unresectable Locally Advanced or Metastatic Cancer

Aulos Bioscience

NCT05267626

RECRUITING Phase 1 150 participants

Study of CP-383 in Patients With Advanced or Metastatic Solid Tumors

Tasca Therapeutics

NCT07030257

RECRUITING Phase 2 150 participants

A Study to Assess Adverse Events and How Intravenously (IV) Infused Telisotuzumab Vedotin (ABBV-399) Moves Through the Body as a Monotherapy in Adult Participants With Previously Treated Non-Squamous Non-Small Cell Lung Cancer (NSCLC)

AbbVie

NCT06568939

RECRUITING Phase 1 150 participants

A Study of [225Ac]Ac-AKY-1189 in Patients With Solid Tumors

Aktis Oncology

NCT07020117

RECRUITING Phase 1 145 participants

A Phase 1 Study of LNCB74 in Advanced Solid Tumors

NextCure

NCT06774963

RECRUITING Phase 2 145 participants

Investigating the Effectiveness of Stereotactic Body Radiotherapy (SBRT) in Addition to Standard of Care Treatment for Cancer That Has Spread Beyond the Original Site of Disease

Memorial Sloan Kettering Cancer Center

NCT03808337

RECRUITING Phase 2 142 participants

Efficacy & Safety of Olvimulogene Nanivacirepvec & Platinum-doublet + Physician's Choice of Immune Checkpoint Inhibitor Compared to Docetaxel in NSCL Cancer

Genelux Corporation

NCT06463665

RECRUITING 140 participants

Analysis of RATS, VATS and Open Lung Resections After Neoadjuvant Chemo-immunotherapy in Patients Performed in Five Referred Centers

Scientific Institute San Raffaele

NCT06626243

RECRUITING Phase 1 140 participants

A Multinational Study Assessing an Oral EGFR Inhibitor, DZD6008 in Patients Who Have Advanced NSCLC With EGFR Mutations (TIAN-SHAN1)

Dizal Pharmaceuticals

NCT06905197

RECRUITING Phase 1 137 participants

A Study of Valemetostat Tosylate Plus Pembrolizumab Versus Pembrolizumab Alone in First-Line NSCLC Without Actionable Genomic Alterations

Daiichi Sankyo

NCT06644768

RECRUITING Phase 1 130 participants

Study of JANX008 in Subjects With Advanced or Metastatic Solid Tumor Malignancies

Janux Therapeutics

NCT05783622

RECRUITING 130 participants

Prospective External Control Cohort In Patients With Newly Diagnosed Advanced or Metastatic EGFR Mutant Non-Small Cell Lung Cancer

N-Power Medicine

NCT07028489

RECRUITING Phase 1 126 participants

Study of TNG260 and an Anti-PD Antibody in STK11 Mutated Solid Tumors

Tango Therapeutics

NCT05887492

RECRUITING Phase 1 124 participants

A Study to Learn About the Study Medicine Called PF-07799544 as Monotherapy or in Combination in People With Advanced Solid Tumors

Pfizer

NCT05538130

RECRUITING Phase 1 121 participants

Study of NEO-201 in Solid Tumors Expansion Cohorts

Precision Biologics

NCT03476681

RECRUITING Phase 2 120 participants

A Study of Cemiplimab Plus Chemotherapy Versus Cemiplimab Plus Chemotherapy Plus Other Cancer Treatments for Adult Patients With Operable Non-Small Cell Lung Cancer (NSCLC)

Regeneron Pharmaceuticals

NCT06465329

RECRUITING Phase 1 113 participants

FT836 With or Without Chemotherapy and/or Monoclonal Antibodies, in Participants With Advanced Solid Tumors

Fate Therapeutics

NCT07216105

RECRUITING Phase 1 110 participants

A Study to Evaluate Safety, Efficacy, and Pharmacokinetics in Participants With Advanced Solid Tumors

Eutilex

NCT04903873

RECRUITING Phase 1 108 participants

Phase 1 Study to Investigate TCRTs KRAS Mutation in Unresectable, Advanced, and/or Metastatic Solid Tumors

AstraZeneca

NCT06218914

RECRUITING Phase 1 101 participants

A Study of KK2269 in Adult Participants With Solid Tumors

Kyowa Kirin Co.

NCT06266299

RECRUITING Phase 1 100 participants

A Study of a Selective ERBB2 Inhibitor (CGT4255), in Patients With Advanced Solid Tumors

Cogent Biosciences

NCT07361562

RECRUITING 100 participants

Early Rebiopsy to Identify Biomarkers of Tumor Cell Survival Following EGFR, ALK, ROS1 or BRAF TKI Therapy

University of Colorado, Denver

NCT03042221

RECRUITING Phase 4 100 participants

Dabrafenib and/or Trametinib Rollover Study

Novartis Pharmaceuticals

NCT03340506

RECRUITING NA 100 participants

Exercise as Maintenance Therapy in Advanced Lung Cancer

Indiana University

NCT06513663

RECRUITING Phase 1 100 participants

Nano-SMART: Nanoparticles With MR Guided SBRT in Centrally Located Lung Tumors and Pancreatic Cancer

Dana-Farber Cancer Institute

NCT04789486

RECRUITING NA 100 participants

LOcally ABLatIve ThErapy for OligopRogressive Lung And Thoracic MalignanciEs (OBLITERATE)

University of California, Davis

NCT06103682

RECRUITING Phase 2 99 participants

A Study of Multiple Therapies in Biomarker-selected Participants With Resectable Stages IB-III Non-small Cell Lung Cancer (NSCLC)

Genentech

NCT04302025

RECRUITING Phase 2 99 participants

Study to Evaluate Sutetinib Maleate Capsule in Locally Advanced or Metastatic Non-small Cell Lung Cancer

Teligene US

NCT05168566

RECRUITING Phase 1 97 participants

Phase I Study of Tolododekin Alfa (ANK-101) in Advanced Solid Tumors

Ankyra Therapeutics

NCT06171750

RECRUITING Phase 1 96 participants

A Study of DR-0202 in Patients With Locally Advanced or Metastatic, Relapsed or Refractory Carcinomas

Dren Bio

NCT06999187

RECRUITING Phase 1 93 participants

A Study Investigating BG-60366 in Adults With Epidermal Growth Factor Receptor (EGFR)-Mutant Non-Small Cell Lung Cancer

BeiGene

NCT06685718

RECRUITING Phase 1 92 participants

AOH1996 for the Treatment of Refractory Solid Tumors

City of Hope Medical Center

NCT05227326

RECRUITING Phase 1 90 participants

TT-10 (PORT-6) and TT-4 (PORT-7) as Single Agents and in Combination in Subjects With Advanced Selected Solid Tumors

Portage Biotech

NCT04969315

RECRUITING Phase 2 90 participants

A Study of Pembrolizumab With or Without Chemotherapy in Combination With Additional Treatments for Advanced Non-Small Cell Lung Cancer (NSCLC) (MK-3475-01G/KEYMAKER U01)

Merck Sharp & Dohme

NCT06731907

RECRUITING Phase 2 86 participants

Cabozantinib in Patients With RET Fusion-Positive Advanced Non-Small Cell Lung Cancer and Those With Other Genotypes: ROS1 or NTRK Fusions or Increased MET or AXL Activity

Memorial Sloan Kettering Cancer Center

NCT01639508

RECRUITING Phase 2 85 participants

Pulmonary Rehabilitation in Advanced Lung Cancer Survivors

Case Comprehensive Cancer Center

NCT07104630

RECRUITING 82 participants

Assess Diversity of Gut Microbiome in Met NSCLC in Correlation to Tx & Adverse Effects

University of California, Irvine

NCT06221800

RECRUITING Phase 1 81 participants

A Study of the Oral EGFR Inhibitor PLB1004 in Non-Small Cell Lung Cancer

Avistone Biotechnology Co.

NCT06046495

RECRUITING Phase 2 80 participants

Adjuvant ctDNA-Adapted Personalized Treatment in Early Stage NSCLC (ADAPT-E)

Stanford University

NCT04585477

RECRUITING Phase 1 77 participants

First in Human Phase 1 Study of AG01 Anti-Progranulin/GP88 Antibody in Advanced Solid Tumor Malignancies

A&G Pharmaceutical

NCT05627960

RECRUITING Phase 2 76 participants

A Study to Evaluate Two Dosing Regimens of Subcutaneous Nivolumab in Combination With Intravenous Ipilimumab and Chemotherapy in Participants With Previously Untreated Metastatic or Recurrent Non-Small Cell Lung Cancer (NSCLC)

Bristol-Myers Squibb

NCT06946797

RECRUITING Phase 1 76 participants

Phase I/IIa Study of H002 in NSCLC With Active EGFR Mutation

RedCloud Bio

NCT05519293

RECRUITING Phase 2 73 participants

Zelenectide Pevedotin in NECTIN4 Amplified Advanced or Metastatic Non-small Cell Lung Cancer

BicycleTx Limited

NCT06933329

RECRUITING Phase 1 73 participants

A Phase 1 of CTX-8371 in Patients With Advanced Malignancies

Compass Therapeutics

NCT06150664

RECRUITING Phase 2 70 participants

IPH5201 and Durvalumab in Patients With Resectable Non-Small Cell Lung Cancer (MATISSE)

Innate Pharma

NCT05742607

RECRUITING Phase 1 70 participants

A Phase 1, Dose-escalation Study of [225Ac]-FPI-2068 in Adult Patients With Advanced Solid Tumours

AstraZeneca

NCT06147037

RECRUITING Phase 2 68 participants

A Study of Targeted Radiation Therapy in People With Non-Small Cell Lung Cancer (NSCLC)

Memorial Sloan Kettering Cancer Center

NCT05657873

RECRUITING Phase 1 67 participants

Trial of Single Protein Encapsulated Doxorubicin, SPEDOX-6 in Advanced Malignancies

University of California, Irvine

NCT07064018

RECRUITING Phase 1 66 participants

EZH2 Inhibitor, Tulmimetostat, and PD-1 Blockade for Treatment of Advanced Non-small Cell Lung Cancer

VA Office of Research and Development

NCT05467748

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Phase Distribution

PhaseTrial count
Phase 1 201
Phase 2 123
Phase 3 62
Phase 4 3

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Non-Small Cell Lung Cancer Trial Landscape

450 indexed Non-Small Cell Lung Cancer studies · 203 recruiting (45%).

Phase mix: 65 late (III/IV) vs 324 early (I/II).

Top sponsor: AstraZeneca (24 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Non-Small Cell Lung Cancer?

PlainTrial tracks 450 US clinical trials for Non-Small Cell Lung Cancer, of which 203 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Non-Small Cell Lung Cancer?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.