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RECRUITING Phase 2

A Study of Novel Combinations in Non-Small Cell Lung Cancer (NSCLC)

NCT07098338 · View on ClinicalTrials.gov ↗

Study Summary

This is a Phase II, multi-center, open-label platform study evaluating novel combination treatment options in participants with locally advanced or metastatic NSCLC. The study will consist of several sub-studies, each evaluating the safety, tolerability, and preliminary antitumour activity of various treatment combinations. This study will be conducted in approximately 80 centers globally across 10 countries.

Conditions Studied

Interventions

  • DRUG Ramucirumab
  • DRUG Rilvegostomig
  • DRUG Dato-DXd

Study Locations (20)

Other

  • Research Site — Nedlands
  • Research Site — Woodville
  • Research Site — Changsha
  • Research Site — Chengdu
  • Research Site — Deyang
  • Research Site — Dongguan
  • Research Site — Fuzhou
  • Research Site — Guangzhou
  • Research Site — Guangzhou
  • Research Site — Hangzhou
  • Research Site — Hefei
  • Research Site — Linyi
  • Research Site — Mianyang

California

  • Research Site — Santa Monica
  • Research Site — Santa Rosa

Georgia

  • Research Site — Atlanta

Maryland

  • Research Site — Baltimore

Texas

  • Research Site — Houston

Virginia

  • Research Site — Fairfax

Ontario

  • Research Site — Toronto

Trial Details

FieldValue
Enrollment Target 278 participants
Start Date 2025-08-07
Est. Completion 2029-04-06
Phase Phase 2

Sponsor

AstraZeneca

1,053 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT07098338

The ClinicalTrials.gov registry entry for NCT07098338 describes a study currently listed as recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 278 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is AstraZeneca, which has 1,053 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Non-Small Cell Lung Cancer appearing as the primary indexed condition, and to 3 interventions — of which Ramucirumab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT07098338 reports 20 study locations spanning 7 distinct geographic areas — top geographies include Other, California, Georgia. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT07098338 about?

NCT07098338 is a clinical study titled "A Study of Novel Combinations in Non-Small Cell Lung Cancer (NSCLC)". This is a Phase II, multi-center, open-label platform study evaluating novel combination treatment options in participants with locally advanced or metastatic NSCLC. The study will consist of several sub-studies, each evaluating the safety, tolerability, and preliminary antitumour activity of variou...

What is the current status of trial NCT07098338?

This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 278 participants. The study started on 2025-08-07. Estimated completion is 2029-04-06.

What conditions does trial NCT07098338 study?

This clinical trial studies the following conditions: Non-Small Cell Lung Cancer. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT07098338?

The interventions under investigation include: Ramucirumab (DRUG), Rilvegostomig (DRUG), Dato-DXd (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT07098338?

This trial is sponsored by AstraZeneca, which has 1,053 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT07098338 being conducted?

This trial has 20 study locations across California, Georgia, Maryland, Texas, Virginia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial