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Volrustomig Priming Regimens Exploratory Phase II Platform Study
NCT06448754 · View on ClinicalTrials.gov ↗
Study Summary
Purpose of this study is to assess the safety, tolerability, pharmacokinetics, immunogenicity, and antitumor activity of volrustomig in combination with other anticancer drugs in participants with specified solid tumors.
Conditions Studied
Interventions
- DRUG Carboplatin
- DRUG Pemetrexed
- DRUG Paclitaxel
- DRUG Ramucirumab
- DRUG Volrustomig
Study Locations (20)
Other
- Research Site — Beijing
- Research Site — Hangzhou
- Research Site — Jinan
- Research Site — Yantai
- Research Site — Zhengzhou
- Research Site — Bois-Guillaume
- Research Site — Caen
- Research Site — Créteil
- Research Site — Dijon
- Research Site — Montpellier
- Research Site — Batumi
- Research Site — Tbilisi
Colorado
- Research Site — Grand Junction
- Research Site — Wheat Ridge
California
- Research Site — Los Angeles
Maryland
- Research Site — Baltimore
Michigan
- Research Site — Detroit
North Carolina
- Research Site — Chapel Hill
Washington
- Research Site — Tacoma
Quebec
- Research Site — Montreal
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 180 participants |
| Start Date | 2024-08-27 |
| Est. Completion | 2027-07-30 |
| Phase | Phase 2 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06448754
The ClinicalTrials.gov registry entry for NCT06448754 describes a study currently listed as recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 180 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is AstraZeneca, which has 1,053 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Non-small Cell Lung Cancer appearing as the primary indexed condition, and to 5 interventions — of which Carboplatin is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT06448754 reports 20 study locations spanning 8 distinct geographic areas — top geographies include Other, Colorado, California. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT06448754 about?
NCT06448754 is a clinical study titled "Volrustomig Priming Regimens Exploratory Phase II Platform Study". Purpose of this study is to assess the safety, tolerability, pharmacokinetics, immunogenicity, and antitumor activity of volrustomig in combination with other anticancer drugs in participants with specified solid tumors.
What is the current status of trial NCT06448754?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 180 participants. The study started on 2024-08-27. Estimated completion is 2027-07-30.
What conditions does trial NCT06448754 study?
This clinical trial studies the following conditions: Non-small Cell Lung Cancer. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT06448754?
The interventions under investigation include: Carboplatin (DRUG), Pemetrexed (DRUG), Paclitaxel (DRUG), Ramucirumab (DRUG), Volrustomig (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT06448754?
This trial is sponsored by AstraZeneca, which has 1,053 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT06448754 being conducted?
This trial has 20 study locations across California, Colorado, Maryland, Michigan, North Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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