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NCT01699607 · ClinicalTrials.gov registry record · NA
Test-retest Reproducibility of [11C]PHNO PET Using the Constant Infusion Paradigm
A NA study of Healthy and Nicotine Dependence, sponsored by Yale University.
- Completed
- Registry status
- NA
- Development phase
- 10
- Enrollment target
- 1
- Study location
NCT01699607: Completed NA study of Healthy and Nicotine Dependence, sponsored by Yale University.
NCT01699607 is a NA study of Healthy and Nicotine Dependence that has completed, run by Yale University. The registered enrollment target is 10 participants, below the 647-participant average among 1,090 other Healthy trials with a reported enrollment target (98% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01699607, a NA study of Healthy and Nicotine Dependence, has completed, sponsored by Yale University.
- COMPLETED
- Registry status
- NA
- Development phase
- 10 participants
- Enrollment target
- 1
- Study location
Study Summary
A research study designed to examine amphetamine-induced dopamine release using the PET imaging agent \[11C\]PHNO in tobacco smokers while currently smoking and during acute withdrawal and in nonsmokers. Twenty healthy men and women tobacco smokers and twenty healthy nonsmokers will be recruited. Each subject will participate in 1 MRI and up to 2 \[11C\]PHNO PET scans. On the study day subjects will participate in two \[11C\]PHNO scans (ideally, the two PET scans will be carried out in the same day). Three hours before the second PET scan, amphetamine (0.5 mg/kg, PO) will be administered. In smokers, the scan will occur at 10-21 days of smoking abstinence.
Primary Outcome
PET images will be obtained in subjects at baseline and after amphetamine administration. Dopamine release will be measured as a percent change in binding potential. Increased dopamine release will result in decreased radiotracer binding because dopamine will displace the radiotracer.
Conditions Studied
Interventions
- DRUG Amphetamine
Study Locations (1)
Connecticut
- Yale University - New Haven
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 10 participants |
| Start Date | 2012-06 |
| Est. Completion | 2013-07 |
| Phase | NA |
What the finished NCT01699607 record still lists
NCT01699607 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 10 participants, a relatively small participant target, below the 647-participant average among 1,090 other Healthy trials with a reported enrollment target (98% lower).
The record links to 2 conditions, with Healthy appearing as the primary indexed condition, and to 1 intervention - of which Amphetamine is the first listed.
NCT01699607 reports a single indexed study location in Connecticut.
Frequently Asked Questions
What is clinical trial NCT01699607 about?
NCT01699607 is a clinical study titled "Test-retest Reproducibility of [11C]PHNO PET Using the Constant Infusion Paradigm". A research study designed to examine amphetamine-induced dopamine release using the PET imaging agent \[11C\]PHNO in tobacco smokers while currently smoking and during acute withdrawal and in nonsmokers. Twenty healthy men and women tobacco smokers and twenty healthy nonsmokers will be recruited. Ea...
What is the current status of trial NCT01699607?
This trial is currently completed. It is a NA study. The enrollment target is 10 participants. The study started on 2012-06. Estimated completion is 2013-07.
What conditions does trial NCT01699607 study?
This clinical trial studies the following conditions: Healthy, Nicotine Dependence.
What interventions are being tested in trial NCT01699607?
The interventions under investigation include: Amphetamine (DRUG).
Who is sponsoring clinical trial NCT01699607?
This trial is sponsored by Yale University, which has 1,492 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT01699607 being conducted?
This trial has 1 study location across Connecticut. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Healthy
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT01699607's enrollment target sits among peer trials
10 1035th of 1090 higher than 35 of 1,090 other Healthy trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Healthy trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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