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RECRUITING Phase 2

CapTemY90 for Grade 2/3 NET Liver Metastases

NCT04339036 · View on ClinicalTrials.gov ↗

Study Summary

This is a Phase 2 evaluation of hepatic-progression free survival among patients with Grade 2 liver-dominant NET metastases undergoing combination therapy with CapTem and Y90 radioembolization.The hypothesis is to confirm safety and to assess if disease control is improved relative to expectation from either therapy alone. A Grade 3 arm was added in 2025.

Interventions

  • DRUG Capecitabine Oral Product
  • DRUG Temozolomide Oral Product
  • COMBINATION_PRODUCT transarterial radioembolization

Study Locations (4)

California

  • UC San Diego — La Jolla

Florida

  • University of Miami Miller School of Medicine-Sylvester Cancer Center — Miami

New York

  • Roswell Park Comprehensive Cancer Center — Buffalo

Pennsylvania

  • University of Pennsylvania — Philadelphia

Trial Details

FieldValue
Enrollment Target 70 participants
Start Date 2021-10-07
Est. Completion 2026-05-01
Phase Phase 2

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT04339036

The ClinicalTrials.gov registry entry for NCT04339036 describes a study currently listed as recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 70 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Abramson Cancer Center at Penn Medicine, which has 332 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 2 conditions, with Neuroendocrine Tumors appearing as the primary indexed condition, and to 3 interventions — of which Capecitabine Oral Product is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT04339036 reports 4 study locations spanning 4 distinct geographic areas — top geographies include California, Florida, New York. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT04339036 about?

NCT04339036 is a clinical study titled "CapTemY90 for Grade 2/3 NET Liver Metastases". This is a Phase 2 evaluation of hepatic-progression free survival among patients with Grade 2 liver-dominant NET metastases undergoing combination therapy with CapTem and Y90 radioembolization.The hypothesis is to confirm safety and to assess if disease control is improved relative to expectation fr...

What is the current status of trial NCT04339036?

This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 70 participants. The study started on 2021-10-07. Estimated completion is 2026-05-01.

What conditions does trial NCT04339036 study?

This clinical trial studies the following conditions: Neuroendocrine Tumors, Neuroendocrine Tumor Grade 2. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT04339036?

The interventions under investigation include: Capecitabine Oral Product (DRUG), Temozolomide Oral Product (DRUG), transarterial radioembolization (COMBINATION_PRODUCT). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT04339036?

This trial is sponsored by Abramson Cancer Center at Penn Medicine, which has 332 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT04339036 being conducted?

This trial has 4 study locations across California, Florida, New York, Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial