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RECRUITING Phase 1

A Study to Investigate Safety and Effectiveness of CRN09682 in Participants With SST2-Expressing NENs and Other Solid Tumors

NCT07129252 · View on ClinicalTrials.gov ↗

Study Summary

This Phase 1/2, multicenter, open-label, FIH study aims to evaluate the safety, tolerability, PK, and preliminary antitumor activity of CRN09682 in participants with SST2-expressing NENs and other solid tumors. The study includes a Dose Escalation Phase to determine the MTD and DLTs. Following MTD identification, additional participants will be enrolled at the expansion dose to further assess safety, tolerability, PK, and antitumor activity.

Interventions

  • DRUG CRN09682

Study Locations (20)

California

  • Crinetics Study Site — Duarte
  • Crinetics Study Site — Newport Beach
  • Crinetics Study Site — Orange
  • Crinetics Study Site — San Francisco

Texas

  • Crinetics Study Site — Austin
  • Crinetics Study Site — Houston
  • Crinetics Study Site — Irving

Other

  • Crinetics Study Site — Barcelona
  • Crinetics Study Site — Barcelona
  • Crinetics Study Site — Madrid

Virginia

  • Crinetics Study Site — Charlottesville
  • Crinetics Study Site — Fairfax

Colorado

  • Crinetics Study Site — Denver

Connecticut

  • Crinetics Study Site — New Haven

Georgia

  • Crinetics Study Site — Atlanta

Kentucky

  • Crinetics Study Site — Lexington

Trial Details

FieldValue
Enrollment Target 150 participants
Start Date 2025-11-26
Est. Completion 2029-08
Phase Phase 1

Sponsor

Crinetics Pharmaceuticals

9 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT07129252

The ClinicalTrials.gov registry entry for NCT07129252 describes a study currently listed as recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 150 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Crinetics Pharmaceuticals, which has 9 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 3 conditions, with Neuroendocrine Tumors appearing as the primary indexed condition, and to 1 intervention — of which CRN09682 is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT07129252 reports 20 study locations spanning 12 distinct geographic areas — top geographies include California, Texas, Other. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT07129252 about?

NCT07129252 is a clinical study titled "A Study to Investigate Safety and Effectiveness of CRN09682 in Participants With SST2-Expressing NENs and Other Solid Tumors". This Phase 1/2, multicenter, open-label, FIH study aims to evaluate the safety, tolerability, PK, and preliminary antitumor activity of CRN09682 in participants with SST2-expressing NENs and other solid tumors. The study includes a Dose Escalation Phase to determine the MTD and DLTs. Following MTD i...

What is the current status of trial NCT07129252?

This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 150 participants. The study started on 2025-11-26. Estimated completion is 2029-08.

What conditions does trial NCT07129252 study?

This clinical trial studies the following conditions: Neuroendocrine Tumors, Neuroendocrine Neoplasm, SST2-positive Neuroendocrine Neoplasms. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT07129252?

The interventions under investigation include: CRN09682 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT07129252?

This trial is sponsored by Crinetics Pharmaceuticals, which has 9 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT07129252 being conducted?

This trial has 20 study locations across California, Colorado, Connecticut, Georgia, Kentucky. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial