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NCT02174549 · ClinicalTrials.gov registry record · Phase 1
Dose-defining Study of Tirapazamine Combined With Embolization in Liver Cancer
A Phase 1 study of Hepatocellular Carcinoma and Neuroendocrine Tumors, sponsored by Teclison.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 25
- Enrollment target
- 2
- Study locations
NCT02174549: Recruiting Phase 1 study of Hepatocellular Carcinoma and Neuroendocrine Tumors, sponsored by Teclison.
NCT02174549 is a Phase 1 study of Hepatocellular Carcinoma and Neuroendocrine Tumors that is actively recruiting participants, run by Teclison. The registered enrollment target is 25 participants, below the 257-participant average among 145 other Hepatocellular Carcinoma trials with a reported enrollment target (90% lower). The trial reports 2 study locations across 2 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02174549, a Phase 1 study of Hepatocellular Carcinoma and Neuroendocrine Tumors, is actively recruiting participants, sponsored by Teclison.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 25 participants
- Enrollment target
- 2
- Study locations
Study Summary
This phase 1 study is to determine the optimal dose and tolerability of a hypoxia-activating agent, tirapazamine, when it is combined with embolization in liver cancer. Liver cancer patients who are Child-Pugh score A, suitable for embolization with tumor no more than 4 nodules are eligible. Tirapazamine will be given by intra-arterial injection before embolization. Treatment effect is evaluated by MRI based on mRECIST criteria. Repeat treatment is necessary only if disease progression. Dose escalation cohort has been completed. Expansion cohort is open for metastatic liver dominant neuroendocrine tumor.
Primary Outcome
Overall Response Rate by RECIST criteria
Conditions Studied
Interventions
- DRUG Tirapazamine
- PROCEDURE Conventional Transarterial Embolization (TAE)
Study Locations (2)
California
- Stanford University - Palo Alto
Pennsylvania
- University of Pennsylvania - Philadelphia
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 25 participants |
| Start Date | 2014-09 |
| Est. Completion | 2025-12-31 |
| Phase | Phase 1 |
What NCT02174549 shows while recruiting
NCT02174549 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 25 participants, a relatively small participant target, below the 257-participant average among 145 other Hepatocellular Carcinoma trials with a reported enrollment target (90% lower).
The record links to 3 conditions, with Hepatocellular Carcinoma appearing as the primary indexed condition, and to 2 interventions - of which Tirapazamine is the first listed.
NCT02174549 reports a single indexed study location in California, Pennsylvania.
Frequently Asked Questions
What is clinical trial NCT02174549 about?
NCT02174549 is a clinical study titled "Dose-defining Study of Tirapazamine Combined With Embolization in Liver Cancer". This phase 1 study is to determine the optimal dose and tolerability of a hypoxia-activating agent, tirapazamine, when it is combined with embolization in liver cancer. Liver cancer patients who are Child-Pugh score A, suitable for embolization with tumor no more than 4 nodules are eligible. Tirapaz...
What is the current status of trial NCT02174549?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 25 participants. The study started on 2014-09. Estimated completion is 2025-12-31.
What conditions does trial NCT02174549 study?
This clinical trial studies the following conditions: Hepatocellular Carcinoma, Neuroendocrine Tumors, Gastrointestinal Cancer Metastatic.
What interventions are being tested in trial NCT02174549?
The interventions under investigation include: Tirapazamine (DRUG), Conventional Transarterial Embolization (TAE) (PROCEDURE).
Who is sponsoring clinical trial NCT02174549?
This trial is sponsored by Teclison, which has 4 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT02174549 being conducted?
This trial has 2 study locations across California, Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT02174549's enrollment target sits among peer trials
25 117th of 145 higher than 29 of 145 other Hepatocellular Carcinoma trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Hepatocellular Carcinoma trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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