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ClinicalTrials.gov 120 recruiting now official registry

Multiple Sclerosis clinical trials

120 of 317 indexed Multiple Sclerosis trials are currently recruiting.

317 US clinical trials · 120 currently recruiting

Multiple Sclerosis is the subject of 317 registered US clinical trials on ClinicalTrials.gov, 120 of them currently open to new participants. 41 are in Phase 3-4 (later-stage) and 74 in Phase 1-2 (earlier-stage). The most active sponsor is Biogen, running 13 of these trials.

The research picture

Multiple Sclerosis has 317 registered US clinical trials, 120 of them open to new participants right now, about 38% of the total.

120
recruiting participants now
38%
of trials open to enrollment
41
in Phase 3–4 (later-stage)
13
top sponsor: Biogen
Phase 141Phase 233Phase 324Phase 417

Active & Recent Trials

317 total, page 6 of 7

COMPLETED NA 40 participants

Emotion Regulation Skills Training for Individuals With MS and Their Support Partners

Johns Hopkins University

NCT03934489

COMPLETED NA 40 participants

Assistive Device Training in Multiple Sclerosis

Portland VA Medical Center

NCT02408718

COMPLETED Phase 2 40 participants

Antibiotic Treatment Trial Directed Against Chlamydia Pneumonia in Multiple Sclerosis

National Center for Research Resources (NCRR)

NCT00043264

COMPLETED NA 39 participants

Consolidation & Interference in Multiple Sclerosis

Kessler Foundation

NCT02081508

COMPLETED NA 37 participants

MS Symptom Management Study

University of Washington

NCT02474940

COMPLETED NA 36 participants

Pilot Diet Study for Multiple Sclerosis

Icahn School of Medicine at Mount Sinai

NCT02986893

COMPLETED NA 35 participants

Improving Prospective Memory Via Telehealth

Trinity Health Of New England

NCT05129293

COMPLETED Phase 1 35 participants

Exercise as a Strategy to Treat Cognitive Dysfunction in Persons With Multiple Sclerosis

University of California, Los Angeles

NCT01219647

COMPLETED Phase 2 33 participants

31P-MRS Imaging to Assess the Effects of CNM-Au8 on Impaired Neuronal Redox State in Multiple Sclerosis.

Clene Nanomedicine

NCT03993171

COMPLETED NA 33 participants

Feasibility of Remote Exercise Training for Hispanics/Latinos With MS

University of Illinois at Chicago

NCT05998616

COMPLETED NA 32 participants

Effects of a Home Based Walking Program Using Rhythmic Auditory Stimulation in Patients With Multiple Sclerosis

The Cleveland Clinic

NCT02065284

COMPLETED NA 32 participants

Waking Hypnosis in the Treatment of MS-related Fatigue

University of Washington

NCT04429789

COMPLETED NA 31 participants

Pilot Study of Transcranial Direct Current Stimulation (tDCS)

NYU Langone Health

NCT02746705

COMPLETED NA 30 participants

Evaluation of a Web-Based Fall Prevention Program on People With Multiple Sclerosis

Oregon Health and Science University

NCT02885233

COMPLETED NA 30 participants

E-Support Groups in Multiple Sclerosis

Columbia University

NCT03574961

COMPLETED NA 30 participants

Restoration of Walking in Multiple Sclerosis Using Treadmill Training.

US Department of Veterans Affairs

NCT00156676

COMPLETED NA 30 participants

EARLY IFNb-1a and Atorvastatin Combination Therapy of Isolated Clinical Syndrome Suggestive of Multiple Sclerosis

University of North Carolina, Chapel Hill

NCT00137176

COMPLETED NA 30 participants

Melatonin for Sleep in MS

University of California, San Francisco

NCT04035889

COMPLETED Phase 4 30 participants

Natalizumab in Preventing Post-partum Relapses in Multiple Sclerosis

State University of New York at Buffalo

NCT03046251

COMPLETED NA 30 participants

Examining the Effects of Video-game Exercise on Mobility and Brain Plasticity in Individuals With Multiple Sclerosis

Ohio State University

NCT01780792

COMPLETED Phase 4 30 participants

Anesthetic Topical Adhesive (Synera™) to Reduce Injection Pain With Subcutaneous Multiple Sclerosis Medications

Brown, Theodore R., M.D., MPH

NCT01834586

COMPLETED NA 30 participants

Impact Program for Multiple Sclerosis

University of Alabama at Birmingham

NCT05165238

COMPLETED 27 participants

Functional and Physiological Responses to Lokomat Therapy (Pilot Study)

US Department of Veterans Affairs

NCT00883142

COMPLETED Phase 1 25 participants

12-week Safety Evaluation of Oral CS-0777 in Multiple Sclerosis Patients

Daiichi Sankyo

NCT00616733

COMPLETED 25 participants

Ocrelizumab Effects on the Metabolome in MS

Johns Hopkins University

NCT03873389

COMPLETED Phase 2 24 participants

A TSEC for Symptom Management in Menopausal Women With Multiple Sclerosis

University of California, San Francisco

NCT02710214

COMPLETED 24 participants

Meningeal Inflammation on 7T MRI as a Tool for Measuring and Predicting Ocrelizumab Response in Multiple Sclerosis

University of Maryland, Baltimore

NCT03396822

COMPLETED Phase 1 24 participants

Body Weight Supported Treadmill Training in Persons With Multiple Sclerosis

University of Illinois at Urbana-Champaign

NCT01992679

COMPLETED NA 23 participants

Combined Effect of Transcranial Direct Current Stimulation (tDCS) and Physical Activity on Gait and Functional Mobility in Participants With Multiple Sclerosis

NYU Langone Health

NCT03658668

COMPLETED NA 22 participants

Management of Pain in Persons With Multiple Sclerosis

University of Washington

NCT00621374

COMPLETED 22 participants

Medical Marijuana and Its Effects on Motor Function in People With Multiple Sclerosis

Colorado State University

NCT02898974

COMPLETED Phase 4 21 participants

Memantine for Spasticity in MS Patients

University of Rochester

NCT00638027

COMPLETED Phase 4 21 participants

Lubiprostone in Patients With Multiple Sclerosis Associated Constipation

University of Rochester

NCT01236534

COMPLETED NA 20 participants

Tysabri Effects on Cognition and Neurodegeneration in Multiple Sclerosis

University of Chicago

NCT01071512

COMPLETED NA 20 participants

A Wheelchair Propulsion Training Program

Washington University School of Medicine

NCT04009187

COMPLETED Phase 1 20 participants

Safety of RG2077 in Patients With Multiple Sclerosis

National Institute of Allergy and Infectious Diseases (NIAID)

NCT00076934

COMPLETED 20 participants

Experimental Evaluation of Wheelchair-Mounted Robotic Arms

University of South Florida

NCT01652352

COMPLETED NA 20 participants

Cognitive Motor Interference Rehabilitation in Persons With Multiple Sclerosis

University of Illinois at Urbana-Champaign

NCT02274935

COMPLETED NA 20 participants

My MS Toolkit: a Symptom Self-management Program for Multiple Sclerosis

University of Michigan

NCT03708276

COMPLETED 20 participants

The Role of Serum Leptin Levels in Multiple Sclerosis Disease Activity While on Interferon Beta 1a (Rebif) Treatment

University of South Florida

NCT01067573

COMPLETED Phase 1 20 participants

Phase I Study of High-Dose Cyclophosphamide and Total Body Irradiation With T Lymphocyte-Depleted Autologous Peripheral Blood Stem Cell or Bone Marrow Rescue in Patients With Multiple Sclerosis

Northwestern Memorial Hospital

NCT00017628

COMPLETED Phase 4 20 participants

A Pharmacokinetic (PK) Study of Natalizumab (Tysabri) at Steady State

Biogen

NCT00744679

COMPLETED Phase 4 19 participants

Study to Evaluate the Feasibility of [18F]Florbetapir PET for Assessment in MS Patients

Institute for Neurodegenerative Disorders

NCT01767493

COMPLETED Phase 3 19 participants

Comparing Risk and Severity of IRRs in Patients Premedicated With Cetirizine vs. Diphenhydramine Prior to Ocrelizumab

Providence Health & Services

NCT04175834

COMPLETED Phase 1 18 participants

Histaminergic Basis of Central Fatigue in Multiple Sclerosis - A Novel Approach

University of Miami

NCT03266965

COMPLETED NA 18 participants

Effects of Targeted Lower Extremity Joint Training on Multiple Sclerosis (MS) Gait Abnormalities

Mount Sinai Rehabilitation Hospital

NCT00906737

COMPLETED 17 participants

Anti-Inflammatory Type II Monocyte Induction by Glatiramer Acetate (Copaxone) Treatment of Multiple Sclerosis

University of California, San Francisco

NCT00819195

COMPLETED 16 participants

Functional Intermuscular Reduction of Spasticity

University of Oklahoma

NCT04403594

COMPLETED NA 16 participants

Multimodal Exercise Training to Reduce Frailty in People With Multiple Sclerosis

University of Kansas Medical Center

NCT06042244

COMPLETED NA 15 participants

A Pilot Randomized Controlled Trial: CoINTEGRATE

University of Michigan

NCT05732285

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Phase Distribution

PhaseTrial count
Phase 1 41
Phase 2 33
Phase 3 24
Phase 4 17

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Multiple Sclerosis Trial Landscape

317 indexed Multiple Sclerosis studies · 120 recruiting (38%).

Phase mix: 41 late (III/IV) vs 74 early (I/II).

Top sponsor: Biogen (13 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Multiple Sclerosis?

PlainTrial tracks 317 US clinical trials for Multiple Sclerosis, of which 120 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Multiple Sclerosis?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.