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Multiple Sclerosis clinical trials
120 of 317 indexed Multiple Sclerosis trials are currently recruiting.
317 US clinical trials · 120 currently recruiting
Multiple Sclerosis is the subject of 317 registered US clinical trials on ClinicalTrials.gov, 120 of them currently open to new participants. 41 are in Phase 3-4 (later-stage) and 74 in Phase 1-2 (earlier-stage). The most active sponsor is Biogen, running 13 of these trials.
The research picture
Multiple Sclerosis has 317 registered US clinical trials, 120 of them open to new participants right now, about 38% of the total.
- 120
- recruiting participants now
- 38%
- of trials open to enrollment
- 41
- in Phase 3–4 (later-stage)
- 13
- top sponsor: Biogen
Active & Recent Trials
317 total, page 6 of 7
Emotion Regulation Skills Training for Individuals With MS and Their Support Partners
Johns Hopkins University
NCT03934489
Assistive Device Training in Multiple Sclerosis
Portland VA Medical Center
NCT02408718
Antibiotic Treatment Trial Directed Against Chlamydia Pneumonia in Multiple Sclerosis
National Center for Research Resources (NCRR)
NCT00043264
Consolidation & Interference in Multiple Sclerosis
Kessler Foundation
NCT02081508
MS Symptom Management Study
University of Washington
NCT02474940
Pilot Diet Study for Multiple Sclerosis
Icahn School of Medicine at Mount Sinai
NCT02986893
Improving Prospective Memory Via Telehealth
Trinity Health Of New England
NCT05129293
Exercise as a Strategy to Treat Cognitive Dysfunction in Persons With Multiple Sclerosis
University of California, Los Angeles
NCT01219647
31P-MRS Imaging to Assess the Effects of CNM-Au8 on Impaired Neuronal Redox State in Multiple Sclerosis.
Clene Nanomedicine
NCT03993171
Feasibility of Remote Exercise Training for Hispanics/Latinos With MS
University of Illinois at Chicago
NCT05998616
Effects of a Home Based Walking Program Using Rhythmic Auditory Stimulation in Patients With Multiple Sclerosis
The Cleveland Clinic
NCT02065284
Waking Hypnosis in the Treatment of MS-related Fatigue
University of Washington
NCT04429789
Pilot Study of Transcranial Direct Current Stimulation (tDCS)
NYU Langone Health
NCT02746705
Evaluation of a Web-Based Fall Prevention Program on People With Multiple Sclerosis
Oregon Health and Science University
NCT02885233
E-Support Groups in Multiple Sclerosis
Columbia University
NCT03574961
Restoration of Walking in Multiple Sclerosis Using Treadmill Training.
US Department of Veterans Affairs
NCT00156676
EARLY IFNb-1a and Atorvastatin Combination Therapy of Isolated Clinical Syndrome Suggestive of Multiple Sclerosis
University of North Carolina, Chapel Hill
NCT00137176
Melatonin for Sleep in MS
University of California, San Francisco
NCT04035889
Natalizumab in Preventing Post-partum Relapses in Multiple Sclerosis
State University of New York at Buffalo
NCT03046251
Examining the Effects of Video-game Exercise on Mobility and Brain Plasticity in Individuals With Multiple Sclerosis
Ohio State University
NCT01780792
Anesthetic Topical Adhesive (Synera™) to Reduce Injection Pain With Subcutaneous Multiple Sclerosis Medications
Brown, Theodore R., M.D., MPH
NCT01834586
Impact Program for Multiple Sclerosis
University of Alabama at Birmingham
NCT05165238
Functional and Physiological Responses to Lokomat Therapy (Pilot Study)
US Department of Veterans Affairs
NCT00883142
12-week Safety Evaluation of Oral CS-0777 in Multiple Sclerosis Patients
Daiichi Sankyo
NCT00616733
Ocrelizumab Effects on the Metabolome in MS
Johns Hopkins University
NCT03873389
A TSEC for Symptom Management in Menopausal Women With Multiple Sclerosis
University of California, San Francisco
NCT02710214
Meningeal Inflammation on 7T MRI as a Tool for Measuring and Predicting Ocrelizumab Response in Multiple Sclerosis
University of Maryland, Baltimore
NCT03396822
Body Weight Supported Treadmill Training in Persons With Multiple Sclerosis
University of Illinois at Urbana-Champaign
NCT01992679
Combined Effect of Transcranial Direct Current Stimulation (tDCS) and Physical Activity on Gait and Functional Mobility in Participants With Multiple Sclerosis
NYU Langone Health
NCT03658668
Management of Pain in Persons With Multiple Sclerosis
University of Washington
NCT00621374
Medical Marijuana and Its Effects on Motor Function in People With Multiple Sclerosis
Colorado State University
NCT02898974
Memantine for Spasticity in MS Patients
University of Rochester
NCT00638027
Lubiprostone in Patients With Multiple Sclerosis Associated Constipation
University of Rochester
NCT01236534
Tysabri Effects on Cognition and Neurodegeneration in Multiple Sclerosis
University of Chicago
NCT01071512
A Wheelchair Propulsion Training Program
Washington University School of Medicine
NCT04009187
Safety of RG2077 in Patients With Multiple Sclerosis
National Institute of Allergy and Infectious Diseases (NIAID)
NCT00076934
Experimental Evaluation of Wheelchair-Mounted Robotic Arms
University of South Florida
NCT01652352
Cognitive Motor Interference Rehabilitation in Persons With Multiple Sclerosis
University of Illinois at Urbana-Champaign
NCT02274935
My MS Toolkit: a Symptom Self-management Program for Multiple Sclerosis
University of Michigan
NCT03708276
The Role of Serum Leptin Levels in Multiple Sclerosis Disease Activity While on Interferon Beta 1a (Rebif) Treatment
University of South Florida
NCT01067573
Phase I Study of High-Dose Cyclophosphamide and Total Body Irradiation With T Lymphocyte-Depleted Autologous Peripheral Blood Stem Cell or Bone Marrow Rescue in Patients With Multiple Sclerosis
Northwestern Memorial Hospital
NCT00017628
A Pharmacokinetic (PK) Study of Natalizumab (Tysabri) at Steady State
Biogen
NCT00744679
Study to Evaluate the Feasibility of [18F]Florbetapir PET for Assessment in MS Patients
Institute for Neurodegenerative Disorders
NCT01767493
Comparing Risk and Severity of IRRs in Patients Premedicated With Cetirizine vs. Diphenhydramine Prior to Ocrelizumab
Providence Health & Services
NCT04175834
Histaminergic Basis of Central Fatigue in Multiple Sclerosis - A Novel Approach
University of Miami
NCT03266965
Effects of Targeted Lower Extremity Joint Training on Multiple Sclerosis (MS) Gait Abnormalities
Mount Sinai Rehabilitation Hospital
NCT00906737
Anti-Inflammatory Type II Monocyte Induction by Glatiramer Acetate (Copaxone) Treatment of Multiple Sclerosis
University of California, San Francisco
NCT00819195
Functional Intermuscular Reduction of Spasticity
University of Oklahoma
NCT04403594
Multimodal Exercise Training to Reduce Frailty in People With Multiple Sclerosis
University of Kansas Medical Center
NCT06042244
A Pilot Randomized Controlled Trial: CoINTEGRATE
University of Michigan
NCT05732285
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 41 |
| Phase 2 | 33 |
| Phase 3 | 24 |
| Phase 4 | 17 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Multiple Sclerosis Trial Landscape
317 indexed Multiple Sclerosis studies · 120 recruiting (38%).
Phase mix: 41 late (III/IV) vs 74 early (I/II).
Top sponsor: Biogen (13 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Multiple Sclerosis?
PlainTrial tracks 317 US clinical trials for Multiple Sclerosis, of which 120 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Multiple Sclerosis?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.