Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

ClinicalTrials.gov 120 recruiting now official registry

Multiple Sclerosis clinical trials

120 of 317 indexed Multiple Sclerosis trials are currently recruiting.

317 US clinical trials · 120 currently recruiting

Multiple Sclerosis is the subject of 317 registered US clinical trials on ClinicalTrials.gov, 120 of them currently open to new participants. 41 are in Phase 3-4 (later-stage) and 74 in Phase 1-2 (earlier-stage). The most active sponsor is Biogen, running 13 of these trials.

The research picture

Multiple Sclerosis has 317 registered US clinical trials, 120 of them open to new participants right now, about 38% of the total.

120
recruiting participants now
38%
of trials open to enrollment
41
in Phase 3–4 (later-stage)
13
top sponsor: Biogen
Phase 141Phase 233Phase 324Phase 417

Active & Recent Trials

317 total, page 7 of 7

COMPLETED NA 15 participants

LoveYourBrain Yoga for Multiple Sclerosis

Dartmouth-Hitchcock Medical Center

NCT03827928

COMPLETED Phase 1 15 participants

Thyroid Hormone for Remyelination in Multiple Sclerosis (MS): A Safety and Dose Finding Study

Oregon Health and Science University

NCT02760056

COMPLETED NA 15 participants

Low Load Resistance Training Using Blood Flow Restriction for People With Multiple Sclerosis

University of Colorado, Denver

NCT04633759

COMPLETED Phase 1 14 participants

In Vivo Characterization of Inflammation With Ferumoxytol, an Ultrasmall Superparamagnetic Iron Oxide Nanoparticle, on 7 Tesla Magnetic Resonance Imaging

National Institute of Neurological Disorders and Stroke (NINDS)

NCT02511028

COMPLETED Phase 4 13 participants

Collection of Blood Samples From Patients With Relapsing MS Who Developed ITP After Receiving Lemtrada

Genzyme, a Sanofi Company

NCT03784898

COMPLETED NA 13 participants

A Study to Analyze the Effect of Acupuncture on Mobility And Quality of Life in Multiple Sclerosis

NYU Langone Health

NCT03174379

COMPLETED 12 participants

Central Nervous System Changes Following OnabotulinumtoxinA Injection in the Bladder

The Methodist Hospital Research Institute

NCT03033355

COMPLETED NA 11 participants

Wearable Lower Extremity Exoskeleton to Promote Walking in Persons With Multiple Sclerosis

The University of Texas Health Science Center, Houston

NCT02519244

COMPLETED Early Phase 1 11 participants

Novel Imaging Markers in SPMS

University of Utah

NCT05357833

COMPLETED Phase 2 10 participants

A Comparison of an Implanted Neuroprosthesis With Sensory Training for Improving Airway Protection in Chronic Dysphagia

National Institute of Neurological Disorders and Stroke (NINDS)

NCT00376506

COMPLETED Phase 1 8 participants

Comparison of the Efficacy and Mechanisms for MBCT and CT for Multiple Sclerosis (MS) Chronic Pain

University of Washington

NCT02012439

COMPLETED Phase 1 7 participants

Constraint-Induced (CI) Movement Therapy for Progressive Multiple Sclerosis (MS)

National Multiple Sclerosis Society

NCT00695084

COMPLETED NA 7 participants

Impact of Direct Current Electrical Stimulation on Spasticity Levels and Functional Muscle Use in MS

CommonSpirit Health

NCT04942938

COMPLETED NA 6 participants

Outcomes of Group Dance and Movement Training in Ambulatory MS Patients

GroundWorks DanceTheater

NCT05943145

COMPLETED 6 participants

Quantitative Magnetic Resonance Imaging (MRI) Sub-Study of MS PATHS

Biogen

NCT04145284

COMPLETED NA 5 participants

Impact of Custom Assistive and Adaptive Technology in Rehabilitation

Madonna Rehabilitation Hospital

NCT03567239

COMPLETED Phase 2

Yoga: Effect on Attention in Aging & Multiple Sclerosis

National Center for Complementary and Integrative Health (NCCIH)

NCT00010998

← Previous Page 7 of 7

Phase Distribution

PhaseTrial count
Phase 1 41
Phase 2 33
Phase 3 24
Phase 4 17

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Multiple Sclerosis Trial Landscape

317 indexed Multiple Sclerosis studies · 120 recruiting (38%).

Phase mix: 41 late (III/IV) vs 74 early (I/II).

Top sponsor: Biogen (13 trials), 9 others listed. 17 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Multiple Sclerosis?

PlainTrial tracks 317 US clinical trials for Multiple Sclerosis, of which 120 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Multiple Sclerosis?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.