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ClinicalTrials.gov 120 recruiting now official registry

Multiple Sclerosis clinical trials

120 of 317 indexed Multiple Sclerosis trials are currently recruiting.

317 US clinical trials · 120 currently recruiting

Multiple Sclerosis is the subject of 317 registered US clinical trials on ClinicalTrials.gov, 120 of them currently open to new participants. 41 are in Phase 3-4 (later-stage) and 74 in Phase 1-2 (earlier-stage). The most active sponsor is Biogen, running 13 of these trials.

The research picture

Multiple Sclerosis has 317 registered US clinical trials, 120 of them open to new participants right now, about 38% of the total.

120
recruiting participants now
38%
of trials open to enrollment
41
in Phase 3–4 (later-stage)
13
top sponsor: Biogen
Phase 141Phase 233Phase 324Phase 417

Active & Recent Trials

317 total, page 5 of 7

COMPLETED Phase 4 155 participants

Long Term Study of Avonex Therapy Following a First Attack of Multiple Sclerosis

Beth Israel Deaconess Medical Center

NCT00179478

COMPLETED Phase 2 150 participants

A Study of C105 on Cognitive Dysfunction in Persons With Multiple Sclerosis

Cognition Pharmaceuticals

NCT00529581

COMPLETED 150 participants

Evaluate the Effect of Switching From Daily Injections of 20mg Glatiramer Acetate (GA) to 40mg GA Three Times a Week in Subjects With Relapsing-remitting Multiple Sclerosis

University at Buffalo

NCT02308670

COMPLETED Phase 3 141 participants

A Study to Evaluate the Safety of Administering Ocrelizumab Per a Shorter Infusion Protocol in Participants With Primary Progressive Multiple Sclerosis (PPMS) and Relapsing Multiple Sclerosis (RMS)

Genentech

NCT03606460

COMPLETED NA 135 participants

CPAP to Treat Cognitive Dysfunction in MS

University of Michigan

NCT02544373

COMPLETED NA 126 participants

Spinal COrd NeuromodulaTor by SpIneX and ScoNE to Treat NeurogeniC BladdEr - SCONE "CONTINENCE" Clinical Study

SpineX

NCT05301335

COMPLETED NA 122 participants

tDCS for the Management of Multiple Sclerosis Related Fatigue

NYU Langone Health

NCT03838770

COMPLETED Phase 2 121 participants

Stress Management for Patients With Multiple Sclerosis

Northwestern University

NCT00147446

COMPLETED Phase 2 120 participants

Trial of Ginkgo as a Treatment for Cognitive Problems in Multiple Sclerosis

US Department of Veterans Affairs

NCT00841321

COMPLETED 120 participants

Allocentric Memory in MS and Resting State Functional MRI

Yale University

NCT02118298

COMPLETED Phase 3 120 participants

Comparison of Safety and Efficacy of Tizanidine Hydrochloride Capsules Versus Zanaflex® (Tizanidine Hydrochloride Tablets) Taken While in the Fed State (Just After a Meal) and in the Fasted State (Before a Meal) in Patients With Moderate to Severe Spasticity.

Elan Pharmaceuticals

NCT00047580

COMPLETED Phase 2 113 participants

Natalizumab High Titer Immunogenicity and Safety

Biogen

NCT00516893

COMPLETED 111 participants

Pilot Study Evaluating Functional and Wellness Outcomes of the Shepherd CAN DO MS Program

Shepherd Center, Atlanta GA

NCT03954717

COMPLETED Phase 1 110 participants

Demonstrate the Bioequivalence of Interferon Beta-1a (INFB) Manufactured by Two Different Processes in Healthy Volunteers

Biogen

NCT01500408

COMPLETED NA 108 participants

Movement-2-Music: Lakeshore Examination of Activity, Disability, and Exercise Response Study

University of Alabama at Birmingham

NCT03797378

COMPLETED Phase 1 104 participants

A Study of ALKS 8700, a Monomethyl Fumarate (MMF) Molecule, in Healthy Adults

Biogen

NCT02201849

COMPLETED NA 100 participants

Speed of Processing Training to Improve Cognition in Multiple Sclerosis

Kessler Foundation

NCT02301260

COMPLETED 85 participants

Does Long-Term Natalizumab (NTZ) Therapy Normalize Brain Atrophy Rates and Quality of Life (QOL) in Relapsing Remitting Multiple Sclerosis (RRMS)?

University of Colorado, Denver

NCT02588053

COMPLETED NA 80 participants

Whole Body Vibration Therapy in Participants With MS Related Balance Deficits

Logan College of Chiropractic

NCT00510523

COMPLETED NA 78 participants

Physical Telerehabilitation in Multiple Sclerosis

Columbia University

NCT03230903

COMPLETED 76 participants

The Effect of Sildenafil Citrate (Viagra® (Registered Trademark)) on Brain Blood Flow in Multiple Sclerosis Patients

National Institutes of Health Clinical Center (CC)

NCT00094068

COMPLETED Phase 4 75 participants

Phase IV Study, Betaseron Versus Copaxone for Relapsing Remitting or CIS Forms of MS Using Triple Dose Gad 3 T MRI

University of Medicine and Dentistry of New Jersey

NCT00176592

COMPLETED Phase 2 75 participants

FolateScan in Autoimmune Disease

Mayo Clinic

NCT00588393

COMPLETED NA 74 participants

Physical Telerehabilitation in Veterans With Multiple Sclerosis

University of Maryland

NCT02346734

COMPLETED NA 73 participants

Treatment of Sleep-disordered Breathing in Patients With SCI

VA Office of Research and Development

NCT02830074

COMPLETED 72 participants

GentleCath™ for Men Intermittent Catheter With FeelClean™ Technology

ConvaTec

NCT05470751

COMPLETED Phase 1 72 participants

An Intravenous Infusion Study of rHIgM22 in Patients With Multiple Sclerosis

Acorda Therapeutics

NCT01803867

COMPLETED Phase 3 64 participants

Effects of Acthar on Recovery From Cognitive Relapses in MS

State University of New York at Buffalo

NCT02290444

COMPLETED Phase 2 61 participants

Effects of Dalfampridine on Cognition in Multiple Sclerosis

State University of New York at Buffalo

NCT02006160

COMPLETED NA 60 participants

Cognitive Markers in Prodromal MS

NYU Langone Health

NCT05543915

COMPLETED 60 participants

MSPT Device Usability Study

Biogen

NCT02664324

COMPLETED 60 participants

A Longitudinal Study of Effect of Copaxone in RRMS Over 24 Months

University at Buffalo

NCT01695434

COMPLETED Phase 3 60 participants

Aspirin for Exercise in Multiple Sclerosis (ASPIRE)

Columbia University

NCT03824938

COMPLETED Phase 3 60 participants

A Multicenter, Open-label Randomized Crossover Trial to Assess Subject Preference for Kemstro™ Compared to Conventional Baclofen Tablets in Subjects With Stable Multiple Sclerosis

UCB Pharma

NCT00139789

COMPLETED NA 56 participants

Characterization of Interferon Beta -1b-Induced Tolerizing Effect in Dendritic Cells

University of North Carolina, Chapel Hill

NCT00630721

COMPLETED Phase 2 52 participants

A Teleheath tDCS Approach to Decrease Cannabis Use

NYU Langone Health

NCT05005013

COMPLETED Phase 2 52 participants

Rolipram to Treat Multiple Sclerosis

National Institute of Neurological Disorders and Stroke (NINDS)

NCT00011375

COMPLETED NA 51 participants

Intervention to Reduce Perceived Cognitive Impairment in Multiple Sclerosis

University of Missouri, Kansas City

NCT03889327

COMPLETED NA 50 participants

Promoting Physical Activity for Persons With Multiple Sclerosis

University of Minnesota

NCT00513448

COMPLETED 50 participants

Effects of Gilenya (Fingolimod) on Thalamus Pathology and Cognitive Impairment in Patients With Relapsing Forms of Multiple Sclerosis

University at Buffalo

NCT02021162

COMPLETED 50 participants

JC Virus Reactivation in Multiple Sclerosis

Beth Israel Deaconess Medical Center

NCT02004444

COMPLETED Phase 1 50 participants

Evaluation of Safety, Tolerability, and PK of VX15/2503 In Patients With MS

Vaccinex

NCT01764737

COMPLETED 50 participants

MR Perfusion Imaging and Hypercapnia (Increased Carbon Dioxide) to Study New Blood Vessel Formation in Multiple Sclerosis

National Institutes of Health Clinical Center (CC)

NCT00064909

COMPLETED NA 49 participants

Mindfulness Meditation in Treating Insomnia in Multiple Sclerosis

Griffin Hospital

NCT03949296

COMPLETED 48 participants

Humoral and T-Cell Responses to COVID-19 Vaccination in Multiple Sclerosis Patients Treated With Ocrelizumab Treated With Ocrelizumab or Natalizumab

Dragonfly Research

NCT04837651

COMPLETED Phase 1 47 participants

Safety Study of BIIB033 in Subjects With Multiple Sclerosis

Biogen

NCT01244139

COMPLETED NA 44 participants

Feasibility of Web-based CBT-I Intervention in Individuals With Multiple Sclerosis

University of Kansas Medical Center

NCT03783585

COMPLETED NA 44 participants

Digital Cognition in Multiple Sclerosis

University of California, San Francisco

NCT03569618

COMPLETED NA 43 participants

Exercise Training Effects on Cognition and Brain Function in Multiple Sclerosis: Project EXACT

Kessler Foundation

NCT03677440

COMPLETED NA 42 participants

Gaze and Postural Stability in Multiple Sclerosis

University of Utah

NCT03521557

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Phase Distribution

PhaseTrial count
Phase 1 41
Phase 2 33
Phase 3 24
Phase 4 17

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Multiple Sclerosis Trial Landscape

317 indexed Multiple Sclerosis studies · 120 recruiting (38%).

Phase mix: 41 late (III/IV) vs 74 early (I/II).

Top sponsor: Biogen (13 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Multiple Sclerosis?

PlainTrial tracks 317 US clinical trials for Multiple Sclerosis, of which 120 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Multiple Sclerosis?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.