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Multiple Sclerosis clinical trials
120 of 317 indexed Multiple Sclerosis trials are currently recruiting.
317 US clinical trials · 120 currently recruiting
Multiple Sclerosis is the subject of 317 registered US clinical trials on ClinicalTrials.gov, 120 of them currently open to new participants. 41 are in Phase 3-4 (later-stage) and 74 in Phase 1-2 (earlier-stage). The most active sponsor is Biogen, running 13 of these trials.
The research picture
Multiple Sclerosis has 317 registered US clinical trials, 120 of them open to new participants right now, about 38% of the total.
- 120
- recruiting participants now
- 38%
- of trials open to enrollment
- 41
- in Phase 3–4 (later-stage)
- 13
- top sponsor: Biogen
Active & Recent Trials
317 total, page 5 of 7
Long Term Study of Avonex Therapy Following a First Attack of Multiple Sclerosis
Beth Israel Deaconess Medical Center
NCT00179478
A Study of C105 on Cognitive Dysfunction in Persons With Multiple Sclerosis
Cognition Pharmaceuticals
NCT00529581
Evaluate the Effect of Switching From Daily Injections of 20mg Glatiramer Acetate (GA) to 40mg GA Three Times a Week in Subjects With Relapsing-remitting Multiple Sclerosis
University at Buffalo
NCT02308670
A Study to Evaluate the Safety of Administering Ocrelizumab Per a Shorter Infusion Protocol in Participants With Primary Progressive Multiple Sclerosis (PPMS) and Relapsing Multiple Sclerosis (RMS)
Genentech
NCT03606460
CPAP to Treat Cognitive Dysfunction in MS
University of Michigan
NCT02544373
Spinal COrd NeuromodulaTor by SpIneX and ScoNE to Treat NeurogeniC BladdEr - SCONE "CONTINENCE" Clinical Study
SpineX
NCT05301335
tDCS for the Management of Multiple Sclerosis Related Fatigue
NYU Langone Health
NCT03838770
Stress Management for Patients With Multiple Sclerosis
Northwestern University
NCT00147446
Trial of Ginkgo as a Treatment for Cognitive Problems in Multiple Sclerosis
US Department of Veterans Affairs
NCT00841321
Allocentric Memory in MS and Resting State Functional MRI
Yale University
NCT02118298
Comparison of Safety and Efficacy of Tizanidine Hydrochloride Capsules Versus Zanaflex® (Tizanidine Hydrochloride Tablets) Taken While in the Fed State (Just After a Meal) and in the Fasted State (Before a Meal) in Patients With Moderate to Severe Spasticity.
Elan Pharmaceuticals
NCT00047580
Natalizumab High Titer Immunogenicity and Safety
Biogen
NCT00516893
Pilot Study Evaluating Functional and Wellness Outcomes of the Shepherd CAN DO MS Program
Shepherd Center, Atlanta GA
NCT03954717
Demonstrate the Bioequivalence of Interferon Beta-1a (INFB) Manufactured by Two Different Processes in Healthy Volunteers
Biogen
NCT01500408
Movement-2-Music: Lakeshore Examination of Activity, Disability, and Exercise Response Study
University of Alabama at Birmingham
NCT03797378
A Study of ALKS 8700, a Monomethyl Fumarate (MMF) Molecule, in Healthy Adults
Biogen
NCT02201849
Speed of Processing Training to Improve Cognition in Multiple Sclerosis
Kessler Foundation
NCT02301260
Does Long-Term Natalizumab (NTZ) Therapy Normalize Brain Atrophy Rates and Quality of Life (QOL) in Relapsing Remitting Multiple Sclerosis (RRMS)?
University of Colorado, Denver
NCT02588053
Whole Body Vibration Therapy in Participants With MS Related Balance Deficits
Logan College of Chiropractic
NCT00510523
Physical Telerehabilitation in Multiple Sclerosis
Columbia University
NCT03230903
The Effect of Sildenafil Citrate (Viagra® (Registered Trademark)) on Brain Blood Flow in Multiple Sclerosis Patients
National Institutes of Health Clinical Center (CC)
NCT00094068
Phase IV Study, Betaseron Versus Copaxone for Relapsing Remitting or CIS Forms of MS Using Triple Dose Gad 3 T MRI
University of Medicine and Dentistry of New Jersey
NCT00176592
FolateScan in Autoimmune Disease
Mayo Clinic
NCT00588393
Physical Telerehabilitation in Veterans With Multiple Sclerosis
University of Maryland
NCT02346734
Treatment of Sleep-disordered Breathing in Patients With SCI
VA Office of Research and Development
NCT02830074
GentleCath™ for Men Intermittent Catheter With FeelClean™ Technology
ConvaTec
NCT05470751
An Intravenous Infusion Study of rHIgM22 in Patients With Multiple Sclerosis
Acorda Therapeutics
NCT01803867
Effects of Acthar on Recovery From Cognitive Relapses in MS
State University of New York at Buffalo
NCT02290444
Effects of Dalfampridine on Cognition in Multiple Sclerosis
State University of New York at Buffalo
NCT02006160
Cognitive Markers in Prodromal MS
NYU Langone Health
NCT05543915
MSPT Device Usability Study
Biogen
NCT02664324
A Longitudinal Study of Effect of Copaxone in RRMS Over 24 Months
University at Buffalo
NCT01695434
Aspirin for Exercise in Multiple Sclerosis (ASPIRE)
Columbia University
NCT03824938
A Multicenter, Open-label Randomized Crossover Trial to Assess Subject Preference for Kemstro™ Compared to Conventional Baclofen Tablets in Subjects With Stable Multiple Sclerosis
UCB Pharma
NCT00139789
Characterization of Interferon Beta -1b-Induced Tolerizing Effect in Dendritic Cells
University of North Carolina, Chapel Hill
NCT00630721
A Teleheath tDCS Approach to Decrease Cannabis Use
NYU Langone Health
NCT05005013
Rolipram to Treat Multiple Sclerosis
National Institute of Neurological Disorders and Stroke (NINDS)
NCT00011375
Intervention to Reduce Perceived Cognitive Impairment in Multiple Sclerosis
University of Missouri, Kansas City
NCT03889327
Promoting Physical Activity for Persons With Multiple Sclerosis
University of Minnesota
NCT00513448
Effects of Gilenya (Fingolimod) on Thalamus Pathology and Cognitive Impairment in Patients With Relapsing Forms of Multiple Sclerosis
University at Buffalo
NCT02021162
JC Virus Reactivation in Multiple Sclerosis
Beth Israel Deaconess Medical Center
NCT02004444
Evaluation of Safety, Tolerability, and PK of VX15/2503 In Patients With MS
Vaccinex
NCT01764737
MR Perfusion Imaging and Hypercapnia (Increased Carbon Dioxide) to Study New Blood Vessel Formation in Multiple Sclerosis
National Institutes of Health Clinical Center (CC)
NCT00064909
Mindfulness Meditation in Treating Insomnia in Multiple Sclerosis
Griffin Hospital
NCT03949296
Humoral and T-Cell Responses to COVID-19 Vaccination in Multiple Sclerosis Patients Treated With Ocrelizumab Treated With Ocrelizumab or Natalizumab
Dragonfly Research
NCT04837651
Safety Study of BIIB033 in Subjects With Multiple Sclerosis
Biogen
NCT01244139
Feasibility of Web-based CBT-I Intervention in Individuals With Multiple Sclerosis
University of Kansas Medical Center
NCT03783585
Digital Cognition in Multiple Sclerosis
University of California, San Francisco
NCT03569618
Exercise Training Effects on Cognition and Brain Function in Multiple Sclerosis: Project EXACT
Kessler Foundation
NCT03677440
Gaze and Postural Stability in Multiple Sclerosis
University of Utah
NCT03521557
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 41 |
| Phase 2 | 33 |
| Phase 3 | 24 |
| Phase 4 | 17 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Multiple Sclerosis Trial Landscape
317 indexed Multiple Sclerosis studies · 120 recruiting (38%).
Phase mix: 41 late (III/IV) vs 74 early (I/II).
Top sponsor: Biogen (13 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Multiple Sclerosis?
PlainTrial tracks 317 US clinical trials for Multiple Sclerosis, of which 120 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Multiple Sclerosis?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.