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A Study to Learn How PF-06821497 (Mevrometostat) Works in Men With Metastatic Castration-resistant Prostate Cancer.
NCT06629779 · View on ClinicalTrials.gov ↗
Study Summary
This study will explore whether a combination of the investigational drug PF-06821497 and enzalutamide will work better than taking enzalutamide alone in participants with mCRPC who are ARSi or abiraterone naïve.
Conditions Studied
Interventions
- DRUG Placebo
- DRUG Enzalutamide
- DRUG PF-06821497
Study Locations (20)
Arizona
- Ironwood Cancer & Research Centers — Chandler
- Ironwood Cancer & Research Centers — Gilbert
- Palo Verde Hematology Oncology — Glendale
- Ironwood Cancer & Research Centers — Glendale
- Ironwood Cancer & Research Centers — Goodyear
- Ironwood Cancer & Research Centers — Mesa
- Ironwood Cancer & Research Centers — Mesa
- Ironwood Cancer & Research Centers — Phoenix
- Ironwood Cancer & Research Centers — Scottsdale
California
- Los Angeles Cancer Network (LACN) — Anaheim
- Los Angeles Cancer Network (LACN) — Fountain Valley
- Los Angeles Cancer Network (LACN) — Glendale
- Los Angeles Cancer Network (LACN) — Glendale
- Los Angeles Cancer Network (LACN) — Los Angeles
- Los Angeles Cancer Network (LACN) — Los Angeles
- Medical Oncology Associates of San Diego — San Diego
Arkansas
- Highlands Oncology — Fayetteville
- Arkansas Urology - Little Rock — Little Rock
- Highlands Oncology — Rogers
- Highlands Oncology Group — Springdale
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 900 participants |
| Start Date | 2024-10-22 |
| Est. Completion | 2028-11-30 |
| Phase | Phase 3 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06629779
The ClinicalTrials.gov registry entry for NCT06629779 describes a study currently listed as recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 900 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Pfizer, which has 769 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Metastatic Castration-Resistant Prostate Cancer appearing as the primary indexed condition, and to 3 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT06629779 reports 20 study locations spanning 3 distinct geographic areas — top geographies include Arizona, California, Arkansas. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT06629779 about?
NCT06629779 is a clinical study titled "A Study to Learn How PF-06821497 (Mevrometostat) Works in Men With Metastatic Castration-resistant Prostate Cancer.". This study will explore whether a combination of the investigational drug PF-06821497 and enzalutamide will work better than taking enzalutamide alone in participants with mCRPC who are ARSi or abiraterone naïve.
What is the current status of trial NCT06629779?
This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 900 participants. The study started on 2024-10-22. Estimated completion is 2028-11-30.
What conditions does trial NCT06629779 study?
This clinical trial studies the following conditions: Metastatic Castration-Resistant Prostate Cancer. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT06629779?
The interventions under investigation include: Placebo (DRUG), Enzalutamide (DRUG), PF-06821497 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT06629779?
This trial is sponsored by Pfizer, which has 769 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT06629779 being conducted?
This trial has 20 study locations across Arizona, Arkansas, California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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