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A Study of XL092 as Single-Agent and Combination Therapy in Subjects With Solid Tumors
NCT03845166 · View on ClinicalTrials.gov ↗
Study Summary
This is a Phase 1, open-label, dose-escalation and expansion study, evaluating the safety, tolerability, pharmacokinetics (PK), preliminary antitumor activity, and effect on biomarkers of XL092 administered alone, in combination with atezolizumab, and in combination with avelumab to subjects with advanced solid tumors.
Conditions Studied
Interventions
- DRUG Atezolizumab
- DRUG XL092
- DRUG Avelumab
Study Locations (20)
California
- Exelixis Clinical Site #6 — Duarte
- Exelixis Clinical Site #49 — La Jolla
- Exelixis Clinical Site #7 — Los Angeles
- Exelixis Clinical Site #84 — Los Angeles
- Exelixis Clinical Site #66 — San Francisco
- Exelixis Clinical Site #71 — Stanford
Florida
- Exelixis Clinical Site #15 — Lake Mary
- Exelixis Clinical Site #24 — Miami
Georgia
- Exelixis Clinical Site #11 — Atlanta
- Exelixis Clinical Site #80 — Atlanta
Michigan
- Exelixis Clinical Site #45 — Ann Arbor
- Exelixis Clinical Site #2 — Grand Rapids
Iowa
- Exelixis Clinical Site #41 — Iowa City
Kansas
- Exelixis Clinical Site #36 — Westwood
Maine
- Exelixis Clinical Site #62 — Scarborough
Maryland
- Exelixis Clinical Site #44 — Baltimore
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 325 participants |
| Start Date | 2019-03-20 |
| Est. Completion | 2027-05-31 |
| Phase | Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT03845166
The ClinicalTrials.gov registry entry for NCT03845166 describes a study currently listed as active not recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 325 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Exelixis, which has 54 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 5 conditions, with Colorectal Cancer appearing as the primary indexed condition, and to 3 interventions — of which Atezolizumab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT03845166 reports 20 study locations spanning 12 distinct geographic areas — top geographies include California, Florida, Georgia. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT03845166 about?
NCT03845166 is a clinical study titled "A Study of XL092 as Single-Agent and Combination Therapy in Subjects With Solid Tumors". This is a Phase 1, open-label, dose-escalation and expansion study, evaluating the safety, tolerability, pharmacokinetics (PK), preliminary antitumor activity, and effect on biomarkers of XL092 administered alone, in combination with atezolizumab, and in combination with avelumab to subjects with ad...
What is the current status of trial NCT03845166?
This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 325 participants. The study started on 2019-03-20. Estimated completion is 2027-05-31.
What conditions does trial NCT03845166 study?
This clinical trial studies the following conditions: Colorectal Cancer, Renal Cell Carcinoma, Metastatic Castration-resistant Prostate Cancer, Hormone Receptor Positive Breast Carcinoma, Neoplasm Malignant. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT03845166?
The interventions under investigation include: Atezolizumab (DRUG), XL092 (DRUG), Avelumab (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT03845166?
This trial is sponsored by Exelixis, which has 54 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT03845166 being conducted?
This trial has 20 study locations across California, Florida, Georgia, Iowa, Kansas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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