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RECRUITING Phase 2

A Study to Test Inavolisib Treatment in Participants With Metastatic Castration-Resistant Prostate Cancer

NCT07287150 · View on ClinicalTrials.gov ↗

Study Summary

This study will evaluate the efficacy and safety of the combination of inavolisib plus enzalutamide compared with physician's choice of alternative androgen receptor pathway inhibitor (ARPi) or docetaxel in biomarker-selected participants with metastatic castrate-resistant prostate cancer (mCRPC) who have received one prior second-generation ARPi.

Interventions

  • DRUG Docetaxel
  • DRUG Enzalutamide
  • DRUG Abiraterone
  • DRUG Inavolisib
  • DIAGNOSTIC_TEST Diagnostic test

Study Locations (10)

Other

  • Seoul National University Hospital — Seoul
  • Severance Hospital, Yonsei University Health System — Seoul
  • Asan Medical Center. — Seoul
  • Samsung Medical Center — Seoul

Iowa

  • Holden Comprehensive Cancer Center — Iowa City

South Carolina

  • Carolina Urologic Research Center — Myrtle Beach

Queensland

  • Sunshine Coast University Hospital — Birtinya

Victoria

  • Box Hill Hospital — Box Hill

São Paulo

  • CEPHO - Centro de Estudos e Pesquisas em Hematologia e Oncologia — Santo André

Quebec

  • Jewish General Hospital — Montreal

Trial Details

FieldValue
Enrollment Target 100 participants
Start Date 2026-03-31
Est. Completion 2029-07-30
Phase Phase 2

Sponsor

Hoffmann-La Roche

758 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT07287150

The ClinicalTrials.gov registry entry for NCT07287150 describes a study currently listed as recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 100 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Hoffmann-La Roche, which has 758 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Metastatic Castration-Resistant Prostate Cancer appearing as the primary indexed condition, and to 5 interventions — of which Docetaxel is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT07287150 reports 10 study locations spanning 7 distinct geographic areas — top geographies include Other, Iowa, South Carolina. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT07287150 about?

NCT07287150 is a clinical study titled "A Study to Test Inavolisib Treatment in Participants With Metastatic Castration-Resistant Prostate Cancer". This study will evaluate the efficacy and safety of the combination of inavolisib plus enzalutamide compared with physician's choice of alternative androgen receptor pathway inhibitor (ARPi) or docetaxel in biomarker-selected participants with metastatic castrate-resistant prostate cancer (mCRPC) wh...

What is the current status of trial NCT07287150?

This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 100 participants. The study started on 2026-03-31. Estimated completion is 2029-07-30.

What conditions does trial NCT07287150 study?

This clinical trial studies the following conditions: Metastatic Castration-Resistant Prostate Cancer. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT07287150?

The interventions under investigation include: Docetaxel (DRUG), Enzalutamide (DRUG), Abiraterone (DRUG), Inavolisib (DRUG), Diagnostic test (DIAGNOSTIC_TEST). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT07287150?

This trial is sponsored by Hoffmann-La Roche, which has 758 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT07287150 being conducted?

This trial has 10 study locations across Iowa, South Carolina, Queensland, Victoria, São Paulo. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial