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ClinicalTrials.gov 89 recruiting now official registry

Melanoma clinical trials

89 of 269 indexed Melanoma trials are currently recruiting.

269 US clinical trials · 89 currently recruiting

Melanoma is the subject of 269 registered US clinical trials on ClinicalTrials.gov, 89 of them currently open to new participants. 19 are in Phase 3-4 (later-stage) and 184 in Phase 1-2 (earlier-stage). The most active sponsor is Memorial Sloan Kettering Cancer Center, running 20 of these trials.

The research picture

Melanoma has 269 registered US clinical trials, 89 of them open to new participants right now, about 33% of the total.

89
recruiting participants now
33%
of trials open to enrollment
19
in Phase 3–4 (later-stage)
20
top sponsor: Memorial Sloan Kettering Cancer Center
Phase 1117Phase 267Phase 316Phase 43

Active & Recent Trials

269 total, page 5 of 6

COMPLETED NA 88 participants

Minimally Invasive Groin Dissection for Melanoma

Mayo Clinic

NCT01500304

COMPLETED Phase 1 84 participants

An Open-label, Phase I/IIa, Dose Escalating Study of 2B3-101 in Patients With Solid Tumors and Brain Metastases or Recurrent Malignant Glioma.

BBB-Therapeutics B.V.

NCT01386580

COMPLETED Phase 1 82 participants

Trial of Autologous, Hapten-Modified Vaccine in Patients With Stage III or IV Melanoma

AVAX Technologies

NCT00257465

COMPLETED Phase 2 81 participants

Relationship Between Tumor Mutation Burden and Predicted Neo-antigen Burden in Patients With Advanced Melanoma or Bladder Cancer Treated With Nivolumab or Nivolumab Plus Ipilimumab (CA209-260)

Memorial Sloan Kettering Cancer Center

NCT02553642

COMPLETED NA 78 participants

Comparison of Video-Based Versus Written Patient Education on Melanoma

University of California, Davis

NCT00826995

COMPLETED Phase 1 69 participants

Sorafenib and Temsirolimus in Treating Patients With Metastatic, Recurrent, or Unresectable Melanoma

National Cancer Institute (NCI)

NCT00349206

COMPLETED Phase 1 68 participants

Phase 1 Safety and Tolerability of MEDI4736 in Combination With Dabrafenib and Trametinib or With Trametinib Alone

MedImmune

NCT02027961

COMPLETED Phase 2 65 participants

MK-3475 in Melanoma and NSCLC Patients With Brain Metastases

Yale University

NCT02085070

COMPLETED Phase 1 64 participants

Oral STAT3 Inhibitor, TTI-101, in Patients with Advanced Cancers

Tvardi Therapeutics, Incorporated

NCT03195699

COMPLETED Phase 2 64 participants

Anti-Tumor Activity Of SB-485232 In Patients With Previously Untreated Metastatic Melanoma

GlaxoSmithKline

NCT00107718

COMPLETED Phase 1 61 participants

Evaluating the Combination of MK-3475 and Sterotactic Body Radiotherapy in Patients With Metastatic Melanoma or NSCLC

Yale University

NCT02407171

COMPLETED Phase 1 61 participants

Study of Combination Therapy With INCMGA00012 (Anti-PD-1), INCAGN02385 (Anti-LAG-3), and INCAGN02390 (Anti-TIM-3) in Participants With Select Advanced Malignancies

Incyte Corporation

NCT04370704

COMPLETED Phase 1 54 participants

A Study of Intratumoral IMO-2125 in Patients With Refractory Solid Tumors

Idera Pharmaceuticals

NCT03052205

COMPLETED NA 53 participants

Evaluating the Use of Fibrin Tissue Adhesive in Melanoma Patients

M.D. Anderson Cancer Center

NCT00506311

COMPLETED Phase 2 51 participants

Trial of pIL-12 Electroporation Malignant Melanoma

OncoSec Medical Incorporated

NCT01502293

COMPLETED Phase 2 51 participants

EPO906 Therapy in Patients With Advanced Melanoma

Novartis Pharmaceuticals

NCT00035165

COMPLETED Phase 2 50 participants

A Study of Talimogene Laherparepvec in Stage IIIc and Stage IV Malignant Melanoma

BioVex Limited

NCT00289016

COMPLETED 50 participants

A Study to Compare Quality of Life and Compliance in Patients Receiving High-dose Interferon Versus Pegylated Interferon in Patients With Surgically Resected Melanoma

St. Luke's Hospital and Health Network, Pennsylvania

NCT01986712

COMPLETED Phase 1 50 participants

Phase I/II Trial of a Long Peptide Vaccine (LPV7) Plus TLR Agonists

Craig L Slingluff, Jr

NCT02126579

COMPLETED Phase 1 48 participants

A Study to Evaluate the Safety and Tolerability of Immunotherapy Combinations in Participants With Advanced Malignancies

Arcus Biosciences

NCT03629756

COMPLETED Phase 2 46 participants

Study of Karenitecin (BNP1350) to Treat Malignant Melanoma

BioNumerik Pharmaceuticals

NCT00062491

COMPLETED Phase 1 46 participants

Bevacizumab Plus Ipilimumab in Patients With Unresectable Stage III or IV Melanoma

Dana-Farber Cancer Institute

NCT00790010

COMPLETED Phase 1 43 participants

Study of the CD40 Agonistic Monoclonal Antibody APX005M

Apexigen America

NCT02482168

COMPLETED 42 participants

Health Communication in Families

Memorial Sloan Kettering Cancer Center

NCT00597961

COMPLETED Phase 1 40 participants

A Safety and Tolerability Study of INCAGN02390 in Select Advanced Malignancies

Incyte Corporation

NCT03652077

COMPLETED Phase 2 40 participants

Volociximab in Combination With DTIC in Patients With Metastatic Melanoma Not Previously Treated With Chemotherapy

PDL BioPharma

NCT00099970

COMPLETED NA 38 participants

Sun Protection and Tanning Awareness in Rural Schools

University of Utah

NCT06694571

COMPLETED Phase 1 36 participants

Intratumoral CAVATAK (CVA21) and Pembrolizumab in Patients With Advanced Melanoma (VLA-011 CAPRA)

Viralytics

NCT02565992

COMPLETED Phase 1 34 participants

Safety Study of Adjuvant Vaccine to Treat Melanoma Patients

Nina Bhardwaj

NCT01079741

COMPLETED Phase 2 34 participants

Erlotinib and Bevacizumab in Treating Patients With Stage IV Melanoma

Vanderbilt-Ingram Cancer Center

NCT00466687

COMPLETED Phase 2 32 participants

Anti-Angiogenesis Agent AG-013736 In Patients With Metastatic Melanoma

Pfizer

NCT00094107

COMPLETED Phase 2 31 participants

PF-3512676 (CPG 7909) Injection For Patients Who Completed An Oncology Study Using PF-3512676 (CPG 7909)

Pfizer

NCT00043368

COMPLETED Phase 1 30 participants

Hepatic Arterial Infusion of Nab-Paclitaxel in Patients With Metastatic Melanoma in the Liver

M.D. Anderson Cancer Center

NCT00833807

COMPLETED Phase 1 30 participants

Pilot Study of a Double Isolation Perfusion Schedule Using Melphalan Alone for Intransit Melanoma or Unresectable Sarcoma of the Extremity

National Cancer Institute (NCI)

NCT00001577

COMPLETED Phase 1 30 participants

Neoadjuvant Combination Therapy With Ipilimumab and HighDose IFN-α2b for Melanoma

Diwakar Davar

NCT01608594

COMPLETED Phase 1 29 participants

Safety and Efficacy Study of GC1008 to Treat Renal Cell Carcinoma or Malignant Melanoma

Genzyme, a Sanofi Company

NCT00356460

COMPLETED NA 29 participants

Videoscopic Versus Open Inguinal Lymphadenectomy for Cancer

Emory University

NCT01526486

COMPLETED NA 27 participants

SAbR Induced Innate Immunity in Urothelial Carcinoma, Melanoma, and Cervical Carcinoma

University of Texas Southwestern Medical Center

NCT02986867

COMPLETED Phase 1 26 participants

Safety Study of Adenovirus Vector Engineered to Express hIL-12 in Combination With Activator Ligand to Treat Melanoma

Alaunos Therapeutics

NCT01397708

COMPLETED 24 participants

Sensitivity/Specificity Study of Non-invasive Imaging for Melanoma Diagnosis

OHSU Knight Cancer Institute

NCT01556503

COMPLETED Phase 2 24 participants

A Study of Lymphoseek® as a Lymphoid Tissue Targeting Agent in Pediatric Patients With Melanoma, Rhabdomyosarcoma, or Other Solid Tumors Who Are Undergoing Lymph Node Mapping

Cardinal Health 414

NCT02509598

COMPLETED Phase 2 23 participants

Pilot hu14.18-IL2 in Resectable Recurrent Stage III or Stage IV Melanoma

University of Wisconsin, Madison

NCT00590824

COMPLETED Phase 2 23 participants

Adjuvant Dabrafenib (GSK2118436) in Patients With Surgically Resected AJCC Stage IIIC Melanoma Characterized by a BRAFV600E/K Mutation

Memorial Sloan Kettering Cancer Center

NCT01682213

COMPLETED Phase 1 23 participants

Dendritic Cell Activating Scaffold in Melanoma

Dana-Farber Cancer Institute

NCT01753089

COMPLETED Phase 1 21 participants

Safety Study of a Melanoma Vaccine (GVAX) With or Without Cyclophosphamide in Patients With Surgically Resected Melanoma

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT01435499

COMPLETED Early Phase 1 20 participants

Injection Of AJCC Stage IIB, IIC, III And IV Melanoma Patients With A Multi-Epitope Peptide Vaccine Using GM-CSF DNA As An Adjuvant: A Pilot Trial To Assess Safety And Immunity

Memorial Sloan Kettering Cancer Center

NCT00580060

COMPLETED Phase 2 20 participants

Ipilimumab vs Ipilimumab Plus Nivolumab in Patients With Stage III-IV Melanoma Who Have Progressed or Relapsed on PD-1 Inhibitor Therapy

Parker Institute for Cancer Immunotherapy

NCT02731729

COMPLETED Phase 2 17 participants

Lenalidomide (Revlimid) to Treat Advanced Ocular Melanoma

National Cancer Institute (NCI)

NCT00109005

COMPLETED Phase 1 17 participants

Phase I of Histone Deacetylase (HDAC) Inhibitor Panobinostat With Ipilimumab With Unresectable III/IV Melanoma

H. Lee Moffitt Cancer Center and Research Institute

NCT02032810

COMPLETED Phase 1 16 participants

X4P-001 and Pembrolizumab in Patients With Advanced Melanoma

X4 Pharmaceuticals

NCT02823405

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Phase Distribution

PhaseTrial count
Phase 1 117
Phase 2 67
Phase 3 16
Phase 4 3

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Melanoma Trial Landscape

269 indexed Melanoma studies · 89 recruiting (33%).

Phase mix: 19 late (III/IV) vs 184 early (I/II).

Top sponsor: Memorial Sloan Kettering Cancer Center (20 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Melanoma?

PlainTrial tracks 269 US clinical trials for Melanoma, of which 89 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Melanoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.