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ClinicalTrials.gov 89 recruiting now official registry

Melanoma clinical trials

89 of 269 indexed Melanoma trials are currently recruiting.

269 US clinical trials · 89 currently recruiting

Melanoma is the subject of 269 registered US clinical trials on ClinicalTrials.gov, 89 of them currently open to new participants. 19 are in Phase 3-4 (later-stage) and 184 in Phase 1-2 (earlier-stage). The most active sponsor is Memorial Sloan Kettering Cancer Center, running 20 of these trials.

The research picture

Melanoma has 269 registered US clinical trials, 89 of them open to new participants right now, about 33% of the total.

89
recruiting participants now
33%
of trials open to enrollment
19
in Phase 3–4 (later-stage)
20
top sponsor: Memorial Sloan Kettering Cancer Center
Phase 1117Phase 267Phase 316Phase 43

Active & Recent Trials

269 total, page 6 of 6

COMPLETED Phase 1 16 participants

Study of Patients With Stage IV Malignant Melanoma Using PS-341 (Bortezomib, Velcade) and Interferon-alpha-2b in Malignant Melanoma

Ohio State University Comprehensive Cancer Center

NCT01462773

COMPLETED Phase 1 15 participants

A Phase I Trial of T Cells Expressing an Anti-GD2 Chimeric Antigen Receptor in Children and Young Adults With GD2+ Solid Tumors

National Cancer Institute (NCI)

NCT02107963

COMPLETED NA 14 participants

Pilot Study for the Evaluation of the Efficacy of Vaccination With Autologous Tumor Cells Plus Granulocyte-macrophage Colony-stimulating Factor (GM-CSF) - in - Adjuvant, Followed by Systemic Low-dose-interleukin-2 (IL-2) Administration, in Patients With High Risk Melanoma

Craig L Slingluff, Jr

NCT00912418

COMPLETED 13 participants

Pharmacokinetic Profiling of Pembrolizumab and Nivolumab in Patients With Melanoma and/or Non-Small Cell Lung Cancer

Mayo Clinic

NCT05740501

COMPLETED Phase 1 11 participants

PET Imaging of Cancer Patients Using [18F]-SKI-249380, a Radiolabeled Dasatinib-Derivative

Memorial Sloan Kettering Cancer Center

NCT01916135

COMPLETED Phase 2 10 participants

An Extension Study Administering YM155 to Subjects Previously Enrolled in Another Protocol Administering YM155

Astellas Pharma

NCT00818480

COMPLETED Phase 1 9 participants

Immune Responses to Autologous Langerhans-type Dendritic Cells Electroporated With mRNA Encoding a Tumor-associated Antigen in Patients With Malignancy: A Single-arm Phase I Trial in Melanoma

Memorial Sloan Kettering Cancer Center

NCT01456104

COMPLETED Phase 4 8 participants

Neoadjuvant Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) in Cutaneous Stage L-lll Melanoma

Mayo Clinic

NCT02451488

COMPLETED Phase 1 8 participants

Safety and Efficacy Study of BMS-908662 in Combination With Ipilimumab in Subjects With Advanced Melanoma

Bristol-Myers Squibb

NCT01245556

COMPLETED 7 participants

CNS and Extracranial Tumor Tissues, CSF, and Blood From Patients With Melanoma Brain Metastases

University of Pittsburgh

NCT02058953

COMPLETED Phase 2 7 participants

BRAF Inhibitor, LGX818, Utilizing a Pulsatile Schedule in Patients With Stage IV or Unresectable Stage III Melanoma Characterized by a BRAFV600 Mutation

Memorial Sloan Kettering Cancer Center

NCT01894672

COMPLETED Phase 1 6 participants

MCS110 With BRAF/MEK Inhibition in Patients With Melanoma

Dana-Farber Cancer Institute

NCT03455764

COMPLETED Phase 4 6 participants

Can We Miss Pigmented Lesions in Psoriasis Patients?

University of Alabama at Birmingham

NCT01053819

COMPLETED Phase 1 5 participants

Dendritic Cell Vaccination in Patients With Advanced Melanoma

University of Pennsylvania

NCT03092453

COMPLETED NA 3 participants

Ipsilateral Peripheral Intravenous Access Procedures (The iPIVAP Study)

Duke University

NCT04570722

COMPLETED Phase 1 2 participants

Pilot Study of Vigil™ + Pembrolizumab for Advanced Melanoma

Gradalis

NCT02574533

COMPLETED Phase 2 2 participants

Phase 2 Study of Neoadjuvant Vemurafenib in Melanoma Patients With Untreated Brain Metastases

Yale University

NCT01781026

COMPLETED Phase 2

Study of Talabostat and Cisplatin in Advanced Melanoma

Point Therapeutics

NCT00083252

COMPLETED Phase 2

TNFerade™ Biologic Plus Radiation for Metastatic Melanoma

GenVec

NCT00261404

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Phase Distribution

PhaseTrial count
Phase 1 117
Phase 2 67
Phase 3 16
Phase 4 3

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Melanoma Trial Landscape

269 indexed Melanoma studies · 89 recruiting (33%).

Phase mix: 19 late (III/IV) vs 184 early (I/II).

Top sponsor: Memorial Sloan Kettering Cancer Center (20 trials), 9 others listed. 19 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Melanoma?

PlainTrial tracks 269 US clinical trials for Melanoma, of which 89 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Melanoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.