Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

COMPLETED Phase 1

Study of Combination Therapy With INCMGA00012 (Anti-PD-1), INCAGN02385 (Anti-LAG-3), and INCAGN02390 (Anti-TIM-3) in Participants With Select Advanced Malignancies

NCT04370704 · View on ClinicalTrials.gov ↗

Study Summary

The study will determine Recommended Phase 2 Dose for all study drugs, based on the safety and tolerability of the following combinations: INCAGN02385 + INCAGN02390 and INCAGN02385 + INCAGN02390 + INCMGA00012.

Conditions Studied

Interventions

  • DRUG INCAGN02385
  • DRUG INCAGN02390
  • DRUG INCMGA00012.

Study Locations (17)

Florida

  • University of Miami Sylvester Comprehensive Cancer Center — Miami
  • H Lee Moffitt Cancer Center and Research — Tampa

Pennsylvania

  • Penn State Hershey Cancer Institute — Hershey
  • Hillman Cancer Center — Pittsburgh

California

  • The Angeles Clinic and Research Institute — Los Angeles

Iowa

  • University of Iowa — Iowa City

Maryland

  • Cancer Center For Blood Disorders A Division of American Oncology Partners P.A — Bethesda

Missouri

  • Washington University — St Louis

New Jersey

  • John Theurer Cancer Center, Hackensack University Medical Center — Hackensack

New York

  • Nyu Langone Laura and Isaac Perlmutter Cancer Center — New York

Trial Details

FieldValue
Enrollment Target 61 participants
Start Date 2020-07-27
Est. Completion 2025-08-25
Phase Phase 1

Sponsor

Incyte Corporation

163 total trials

Interested in This Trial?

Always speak with your doctor before enrolling in a clinical trial.

Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT04370704

The ClinicalTrials.gov registry entry for NCT04370704 describes a study currently listed as completed. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 61 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Incyte Corporation, which has 163 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Melanoma appearing as the primary indexed condition, and to 3 interventions — of which INCAGN02385 is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT04370704 reports 17 study locations spanning 15 distinct geographic areas — top geographies include Florida, Pennsylvania, California. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT04370704 about?

NCT04370704 is a clinical study titled "Study of Combination Therapy With INCMGA00012 (Anti-PD-1), INCAGN02385 (Anti-LAG-3), and INCAGN02390 (Anti-TIM-3) in Participants With Select Advanced Malignancies". The study will determine Recommended Phase 2 Dose for all study drugs, based on the safety and tolerability of the following combinations: INCAGN02385 + INCAGN02390 and INCAGN02385 + INCAGN02390 + INCMGA00012.

What is the current status of trial NCT04370704?

This trial is currently completed. It is a Phase 1 study. The enrollment target is 61 participants. The study started on 2020-07-27. Estimated completion is 2025-08-25.

What conditions does trial NCT04370704 study?

This clinical trial studies the following conditions: Melanoma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT04370704?

The interventions under investigation include: INCAGN02385 (DRUG), INCAGN02390 (DRUG), INCMGA00012. (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT04370704?

This trial is sponsored by Incyte Corporation, which has 163 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT04370704 being conducted?

This trial has 17 study locations across California, Florida, Iowa, Maryland, Missouri. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial