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NCT02731729 · ClinicalTrials.gov registry record · Phase 2
Ipilimumab vs Ipilimumab Plus Nivolumab in Patients With Stage III-IV Melanoma Who Have Progressed or Relapsed on PD-1 Inhibitor Therapy
A Phase 2 study of Melanoma, sponsored by Parker Institute for Cancer Immunotherapy.
- Completed
- Registry status
- Phase 2
- Development phase
- 20
- Enrollment target
- 7
- Study locations
NCT02731729: Completed Phase 2 study of Melanoma, sponsored by Parker Institute for Cancer Immunotherapy.
NCT02731729 is a Phase 2 study of Melanoma that has completed, run by Parker Institute for Cancer Immunotherapy. The registered enrollment target is 20 participants, below the 706-participant average among 266 other Melanoma trials with a reported enrollment target (97% lower). The trial reports 7 study locations across 4 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02731729, a Phase 2 study of Melanoma, has completed, sponsored by Parker Institute for Cancer Immunotherapy.
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 20 participants
- Enrollment target
- 7
- Study locations
Study Summary
The purpose of this research study is to learn whether patients whose disease grows after being treated with nivolumab or pembrolizumab respond to ipilimumab (Yervoy®) alone or in combination with nivolumab (Opdivo®).
Primary Outcome
Overall Response Rate was defined as any participant who had a Complete Response (CR) or Partial Response (PR) as defined by RECIST v1.1 by week 18 of treatment.
Conditions Studied
Interventions
- DRUG nivolumab
- DRUG ipilimumab
Study Locations (7)
California
- University of California, Los Angeles - Los Angeles
- University of California, San Francisco - San Francisco
New York
- Memorial Sloan Kettering Westchester - Harrison
- Memorial Sloan Kettering Cancer Center - New York
Pennsylvania
- Lehigh Valley Health Network - Allentown
- University of Pennsylvania - Philadelphia
New Jersey
- Memorial Sloan Kettering Basking Ridge - Basking Ridge
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 20 participants |
| Start Date | 2016-06-21 |
| Est. Completion | 2019-02-13 |
| Phase | Phase 2 |
What the finished NCT02731729 record still lists
NCT02731729 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 20 participants, a relatively small participant target, below the 706-participant average among 266 other Melanoma trials with a reported enrollment target (97% lower).
The record links to 1 condition, with Melanoma appearing as the primary indexed condition, and to 2 interventions - of which nivolumab is the first listed.
NCT02731729 lists 7 locations in 4 states (California, New York, Pennsylvania).
Frequently Asked Questions
What is clinical trial NCT02731729 about?
NCT02731729 is a clinical study titled "Ipilimumab vs Ipilimumab Plus Nivolumab in Patients With Stage III-IV Melanoma Who Have Progressed or Relapsed on PD-1 Inhibitor Therapy". The purpose of this research study is to learn whether patients whose disease grows after being treated with nivolumab or pembrolizumab respond to ipilimumab (Yervoy®) alone or in combination with nivolumab (Opdivo®).
What is the current status of trial NCT02731729?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 20 participants. The study started on 2016-06-21. Estimated completion is 2019-02-13.
What conditions does trial NCT02731729 study?
This clinical trial studies the following conditions: Melanoma.
What interventions are being tested in trial NCT02731729?
The interventions under investigation include: nivolumab (DRUG), ipilimumab (DRUG).
Who is sponsoring clinical trial NCT02731729?
This trial is sponsored by Parker Institute for Cancer Immunotherapy, which has 5 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT02731729 being conducted?
This trial has 7 study locations across California, New Jersey, New York, Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Melanoma
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT02731729's enrollment target sits among peer trials
20 229th of 266 higher than 36 of 266 other Melanoma trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Melanoma trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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